A5041081626- Heart Rate Variability and Autonomic Control
- Liver Disease and Transplantation
- Nematode management and characterization studies
- Nitric Oxide and Endothelin Effects
- Liver Disease Diagnosis and Treatment
- Vagus Nerve Stimulation Research
- Sulfur Compounds in Biology
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Non-Invasive Vital Sign Monitoring
- Plant Parasitism and Resistance
- Circadian rhythm and melatonin
- Nicotinic Acetylcholine Receptors Study
- Cassava research and cyanide
- Amino Acid Enzymes and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Stress Responses and Cortisol
- Thermoregulation and physiological responses
- Complex Systems and Time Series Analysis
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- Infrared Thermography in Medicine
- Renal function and acid-base balance
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
University College London
2016-2025
The Royal Free Hospital
2007-2024
Roland Hill (United Kingdom)
2003-2024
Saveetha University
2024
University College Lahore
2020
University of Padua
2017
The London College
2017
Tehran University of Medical Sciences
1998-2015
Tarbiat Modares University
2009-2015
Copenhagen University Hospital
2013
Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil-derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this posttranslational protein modification via oxidation nitrite (NO(2)(-)) nitrogen dioxide (NO(2)(*)). Herein, we show that MPO concentrates in the subendothelial matrix tissues by transcytotic mechanism serves as catalyst ECM tyrosine nitration. Purified released intraluminal degranulation activated...
Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil–derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this posttranslational protein modification via oxidation nitrite (NO2–) nitrogen dioxide (NO2•). Herein, we show that MPO concentrates in the subendothelial matrix tissues by transcytotic mechanism serves as catalyst ECM tyrosine nitration. Purified released intraluminal degranulation activated human PMNs...
This study explores the hypothesis that inflammatory response induced by administration of lipopolysaccharide (LPS) exacerbates brain edema in cirrhotic rats; and if so whether this is associated with altered metabolism ammonia or anatomical disturbance blood-brain barrier. Adult Sprague-Dawley rats 4 weeks after bile duct ligation (BDL)/Sham-operation, naïve fed a hyperammonemic diet (HD), were injected LPS (0.5 mg/kg, intraperitoneally) saline, killed 3 hours later. increased water HD,...
Pulse oximetry is routinely used for monitoring patients' oxygen saturation levels with little regard to the variability of this physiological variable. There are few published studies on (OSV), none describing and its pattern in a healthy adult population. The aim study was characterize OSV using several parameters; regularity (sample entropy analysis), self-similarity [detrended fluctuation analysis (DFA)] complexity [multiscale (MSE) analysis]. Secondly, determine if there were any...
Heart rate variability (HRV) is reduced in several clinical settings associated with either systemic inflammation or neuropsychiatric impairment. The possibility that the changes HRV observed patients impairment might relate to overproduction of inflammatory cytokines does not seem have been considered studies undertaken date. decreased liver cirrhosis but its relationship performance, commonly these patients, unknown. aim this study was investigate between HRV, hepatic encephalopathy, and...
Plasma melatonin profile abnormalities have been described in patients with cirrhosis and generally attributed to impaired hepatic metabolism. The possibility that they might reflect circadian clock dysfunction has not explored. In addition, the relationship between plasma profiles sleep disturbances observed these remains unclear. aims of this study were: (i) evaluate function metabolism cirrhotic patients, (ii) sleep-wake behavior.The population comprised 20 (mean (range) age, 59 (39-77)...
Cardiac cycle is regulated by a complex interplay between autonomic nervous system and cardiac pacemaker cells. Decreased heart rate variability (HRV) increased rhythm regularity are associated with poor prognosis in patients systemic inflammation (e.g., sepsis). However, the underlying mechanism of decreased HRV not understood. It known that greater could indicate uncoupling system's components. The present study aimed to test hypothesis impaired responsiveness may lead cardiovascular...
Normal human breathing exhibits complex variability in both respiratory rhythm and volume. Analyzing such nonlinear fluctuations may provide clinically relevant information patients with illnesses as asthma. We compared the cycle-by-cycle of inter-breath interval (IBI) lung volume (LV) among healthy volunteers various types Continuous datasets were collected from forty age-matched men including 10 volunteers, controlled atopic asthma, uncontrolled non-atopic asthma during 60 min spontaneous...
The aim of this study was to investigate the hypothesis that opioid system is involved in development hepatic fibrosis.The effect naltrexone (an receptor antagonist) on fibrosis bile duct ligated (BDL) or sham rats assessed by histology and hydroxyproline levels. Liver matrix metalloproteinase 2 (MMP-2) measured zymography, alpha smooth muscle actin (alpha-SMA) CD45 (leucocyte common antigen) immunohistochemistry. redox state liver glutathione (GSH)/oxidised (GSSG) S-nitrosothiol Subtypes...
Injectable In situ gel-forming chitosan/β-glycerol phosphate (CS/β-Gp) solution can be introduced into the body in a minimally invasive manner prior to solidifying within target tissue. This hydrogel is good candidate for achieving prolonged drug delivery system insulin considering its high molecular weight. addition physicochemical characterization of this hydrogel, vitro and vivo applications were studied as sustained system. release studies, 19–63% total was released from CS/β-Gp 150 h at...
The Poincaré plot is a geometrical technique used to visualise and quantify the correlation between two consecutive data points in time-series. Since dynamics of fluctuations physiological rhythms exhibit long-term memory, this study aimed extend by calculating sequential time-series, rather than points. By incorporating so-called lag, we hope integrate temporal aspect into quantifying correlation, depict whether system holds prolonged association events separated time. In doing so, it...
Abstract Background & Aims Sleep preparation/onset are associated with peripheral vasodilatation and a decrease in body temperature. The hyperdynamic syndrome exhibited by patients cirrhosis may impinge on sleep preparation, thus contributing to their difficulties falling asleep. aim of this study was the assessment skin temperature, relation sleep‐wake patterns, cirrhosis. Methods Fifty‐three subjects were initially recruited, 46 completed study. Of final 46, 12 outpatients cirrhosis,...
New Findings What is the central question of this study? physiological interpretation fluctuations observed during normobaric hypoxia in healthy individuals? main finding and its importance? There a significant flow information between other cardio‐respiratory time series graded hypoxia. Analysis pattern variations has potential for non‐invasive assessment engagement respiratory control system health disease. Abstract Peripheral capillary oxygen saturation ( ) exhibits complex The...
Abstract Decompensated liver disease is complicated by multi‐organ failure and poor prognosis. The prognosis of patients with often dictates clinical management. Current prognostic models have focused on biomarkers considered as individual isolated units. Network physiology assesses the interactions among multiple physiological systems in health irrespective anatomical connectivity defines influence or dependence one organ system another. Indeed, recent applications network mapping methods...
Acceleration of the heart rate in response to catecholamines is impaired cirrhosis. In this study, we tested hypothesis that increased formation reactive nitrogen species biliary cirrhosis causes nitration cardiac proteins and leads chronotropic function. Bile duct-ligated (rats with cirrhosis) or sham-operated rats were injected daily either saline, N(G)-L-nitro-arginine methyl ester (L-NAME), N-acetylcysteine for 7 days from week 3 4 after surgery. Cardiac responsiveness beta-adrenergic...
Sepsis is a complex disease involving multiple organ systems. A network physiology approach to sepsis may reveal collective system behaviours and intrinsic interactions. However, mapping functional connectivity for individual patients has been challenging due the lack of analytical methods evaluating physiological networks using routine clinical laboratory data. This study explored use parenclitic assess predict outcomes based on Data from 162 meeting Sepsis-3 criteria were retrospectively...
Background: Physiological variables provide critical insights into the integrated control of cardiorespiratory system, reflecting body's real-time responses to internal and external perturbations. Visualizing exchange information between different components system is beneficial for monitoring individuals in various clinical settings extreme environments. This study aimed develop a non-invasive method, using principles theory, visualize flow physiological variables, with focus on stressors....