A5011215310- Pancreatic function and diabetes
- Cardiovascular Effects of Exercise
- Genetics and Neurodevelopmental Disorders
- Sports injuries and prevention
- Diabetes and associated disorders
- Physical Activity and Health
- Cardiovascular and exercise physiology
- Immune Cell Function and Interaction
- FOXO transcription factor regulation
- Genetic Syndromes and Imprinting
- Metabolism, Diabetes, and Cancer
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
University of British Columbia
2018-2023
British Columbia Children's Hospital
2022-2023
Abstract Aims/hypothesis Pancreatic islets depend on cytosolic calcium (Ca 2+ ) to trigger the secretion of glucoregulatory hormones and transcriptional regulation genes important for islet response stimuli. To date, there has not been an attempt profile Ca -regulated gene expression in all cell types. Our aim was construct a large single-cell transcriptomic dataset from human exposed conditions that would acutely induce or inhibit intracellular signalling, while preserving biological...
To determine the psychological impact of a cardiovascular disease (CVD) diagnosis identified during preparticipation screening (PPS) masters athletes.Cross-sectional study.Masters athletes diagnosed with CVD through Masters Athletes Screening Study.Sixty-seven (89.6% male, mean age at 60.1 ± 7.1 years, range 40-76) diagnoses coronary artery (CAD) (73.1%), high premature ventricular contraction burden (9.0%), mitral valve prolapse (7.5%), atrial fibrillation (AF) (3.0%), bicuspid aortic...
Abstract Aims/hypothesis Pancreatic islets depend on cytosolic calcium to trigger the secretion of glucoregulatory hormones and regulate transcription genes important for response stimuli. To date, there has not been an attempt profile calcium-regulated gene expression in all islet cell types. Our aim was construct a large single-cell transcriptomic dataset from human exposed conditions that would acutely induce or inhibit intracellular signalling, while preserving biological heterogeneity....
Abstract Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent induction of local islet inflammation activating inflammatory pathways macrophages. We performed an unbiased phenotypic investigation macrophages early stage formation using single RNA sequencing resident mice with and without amyloidogenic form human polypeptide (hIAPP). This revealed that MHC Class II antigen presentation genes were strongly down-regulated during...