A5088923848- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Osteoarthritis Treatment and Mechanisms
- Pain Management and Treatment
- Neuroscience and Neuropharmacology Research
- Musculoskeletal pain and rehabilitation
- Cancer Research and Treatments
- Pain Management and Placebo Effect
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Patient Satisfaction in Healthcare
- Nutrition and Health in Aging
- Dental Anxiety and Anesthesia Techniques
- Receptor Mechanisms and Signaling
- Thermoregulation and physiological responses
- Photoreceptor and optogenetics research
- Ion Channels and Receptors
- Global Health Care Issues
- Pain Management and Opioid Use
- Inflammatory mediators and NSAID effects
- Anesthesia and Pain Management
- Contact Dermatitis and Allergies
- Virus-based gene therapy research
- Insurance, Mortality, Demography, Risk Management
- Nerve injury and regeneration
National Sun Yat-sen University
2024
National Cheng Kung University Hospital
2011-2022
E-Da Hospital
2015-2017
Chi Mei Medical Center
2011
I-Shou University
2007
Complex regional pain syndrome (CRPS) is related to microcirculation impairment associated with tissue hypoxia and peripheral cytokine overproduction in the affected limb. Previous studies suggest that pathogenesis involves inducible factor-1α (HIF-1α) exaggerated inflammatory response. 1-methylpropyl 2-imidazolyl disulfide (PX-12) acts as thioredoxin-1 (Trx-1) inhibitor decreases level of HIF-1α, can rapidly be metabolized for Trx-1 redox inactivation. This study hypothesized PX-12 decrease...
N-methyl-D-aspartate and other glutamate receptors have been shown to present on the peripheral axons of primary afferents, injection N-methyl-D-aspartate-receptor antagonists can suppress hyperalgesia allodynia. Thus, this study examined postoperative analgesic adverse effects local ketamine administered postoperatively.Ketamine (0.3%, 3 mL) or saline was subcutaneously infiltrated before incision in a double-blind manner using sample population 40 patients undergoing circumcision surgery,...
Introduction Previous studies have demonstrated that cytokines, transforming growth factor (TGF-β1), and brain-derived neurotrophic (BDNF) can impact the intensity of pain in rodents. However, roles TGF-β1 BDNF humans with chronic osteoarthritis remains unclear, no comparison between plasma central cerebral spinal fluid (CSF) has been conducted. Methods Patients who were scheduled to receive anesthesia enrolled. The was evaluated a visual analogue scale (VAS). In addition, patients...
Vortioxetine (VOR) is recognized to exert antidepressant actions. However, whether this drug modifies ionic currents in excitable cells remains unclear. The aim of study was explore the electrophysiological effects VOR and other related compounds pituitary GH3 Neuro-2a cells. suppressed delayed-rectifier K+ current (IK(DR)) a concentration-, time-, state-dependent manner. Effective IC50 values needed inhibit peak sustained IK(DR) were computed be 31.2 8.5 μM, respectively, while KD value...
Transcutaneous electrical nerve stimulators (TENSs) have been proved to be effective in muscle pain management for several decades. However, there is no consensus the optimal TENS program. Previous research demonstrated that a 100 Hz (L-TENS) provided better analgesia than conventional (< 5 Hz). compared higher-frequency (> Hz) with TENS. We used 5000 (5 kHz) frequency (M-TENS) and an L-TENS compare analgesic effect on mice skin/muscle incision retraction model. Three groups of were (sham,...
Abstract Nalbuphine (NAL) is recognized as a mixer with the κ‐opioid receptor agonist and μ‐opioid antagonist. However, whether this drug causes any modifications in neuronal ionic currents unclear. The effects of NAL on mHippoE‐14 hippocampal neurons were investigated. In whole‐cell current recordings, suppressed peak amplitude voltage‐gated Na + ( I ) an IC 50 value 1.9 μM. It shifted steady‐state inactivation curve to hyperpolarized potential, suggesting that there voltage dependence...
PT-2385 is currently regarded as a potent and selective inhibitor of hypoxia-inducible factor-2α (HIF-2α), with potential antineoplastic activity. However, the membrane ion channels changed by this compound are obscure, although it reasonable to assume that might act on surface before entering cell´s interior. In study, we intended explore whether related compounds make any adjustments plasmalemmal ionic currents pituitary tumor (GH3) cells human 13-06-MG glioma cells. Cell exposure...
Abstract The hypoxic microenvironment, an important feature of human solid tumors but absent in normal tissues, may provide opportunity for cancer-specific gene theapy. We constructed two vectors, both under the control nine copies hypoxia responsive element (HRE): (1) a herpes simplex virus type 1 thymidine kinase (TK) and enhanced green fluorescent protein (eGFP) fusion gene, (2) triple-fusion-gene, cytosine deaminase (CD), uracil phosphoribosyltransferase (UPRT) monomeric DsRed (mDsRed)....
<h3>Objectives</h3> To determine whether cumulative weight-bearing from workplace was dose-dependently related to risk of knee osteoarthritis (OA). <h3>Methods</h3> The registered workers two Salt Production Societies, Chigu and Beimen, in southern Taiwan between the years 1961 2002 were recruited. A structured questionnaire used collect occupational history OA symptoms. Those with symptoms seen by a physician, diagnosed according American College Rheumatology Criteria for Classification...