A5065806371- Genital Health and Disease
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Colorectal and Anal Carcinomas
- Renal and related cancers
- Urinary Bladder and Prostate Research
- Urologic and reproductive health conditions
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- PARP inhibition in cancer therapy
- Breast Implant and Reconstruction
- Ethics and Legal Issues in Pediatric Healthcare
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Colorectal Cancer Screening and Detection
- Pharmacology and Obesity Treatment
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Female Genital Mutilation/Cutting Issues
Saarland University
2016-2025
Fachhochschule Wiener Neustadt
2021-2024
University Hospital Bonn
2019-2023
Universitätsklinikum des Saarlandes
2023
North-Western State Medical University named after I.I. Mechnikov
2015-2019
University of Bonn
2019
Shanghai Jiao Tong University
2018
Digital pathology provides a possibility for computational analysis of histological slides and automatization routine pathological tasks. Histological are very heterogeneous concerning staining, sections' thickness, artifacts arising during tissue processing, cutting, digitization. In this study, we digitally reproduce major types artifacts. Using six datasets from four different institutions digitized by scanner systems, systematically explore artifacts' influence on the accuracy...
Abstract Pathologic examination of prostate biopsies is time consuming due to the large number slides per case. In this retrospective study, we validate a deep learning-based classifier for cancer (PCA) detection and Gleason grading (AI tool) in biopsy samples. Five external cohorts patients with multifocal were analyzed from high-volume pathology institutes. A total 5922 H&E sections representing 7473 cores 423 patient cases (digitized using three scanners) assessed concerning tumor...
Digital pathology adoption allows for applying computational algorithms to routine tasks. Our study aimed develop a clinical-grade artificial intelligence (AI) tool precise multiclass tissue segmentation in colorectal specimens (resections and biopsies) clinically validate the tumor detection biopsy specimens. The training data set included 241 precisely manually annotated whole-slide images (WSIs) from multiple institutions. algorithm was trained semantic of 11 classes with an additional...
Congenital lower urinary-tract obstruction (LUTO) is caused by anatomical blockage of the bladder outflow tract or functional impairment urinary voiding. About three out 10,000 pregnancies are affected. Although several monogenic causes have been defined, it unknown whether congenital LUTO has a cause. Exome sequencing in family with four affected individuals urethra identified rare nonsense variant (c.2557C>T [p.Arg853∗]) BNC2, encoding basonuclin 2, tracking over generations. Re-sequencing...
Currently, no established biomarkers are recommended for the routine diagnosis of penile carcinoma (PeCa). The rising incidence this human papillomavirus (HPV)-related cancer entity highlights need promising candidates. Calprotectin subunits S100A8 and S100A9 mark myeloid-derived suppressor cells in other HPV-related entities while their receptor CD147 was discussed to identify patients with PeCa at a higher risk poor prognoses treatment failure. We thus examined expression using...
Although microRNAs are described as promising biomarkers in many tumor types, little is known about their role PSCC. Thus, we attempted to identify miRNAs involved development and metastasis distinct histological subtypes considering the impact of HPV infection. In a first step, microarray analyses were performed on RNA from formalin-fixed, paraffin-embedded (22), normal (8) tissue samples. Microarray data validated for selected by qRT-PCR an enlarged cohort, including 27 18 tissues. We...
Human papilloma virus (HPV) infections are one of the most common sexually transmitted diseases. We present case a 77-year-old Caucasian male with enormous genital warts penis, scrotum, groins and anus. Lesions were excised by electrosurgery. The histological examination revealed Condylomata gigantea as well an invasive perianal squamous cell carcinoma. Mucosal “low-risk” HPV type 6 was detected. patient had history immunosuppressing disease. During 4-year follow-up, multiple relapses...
Background: Advanced penile carcinoma is characterized by poor prognosis. Most data on prognostic factors are based small study cohorts, and even meta-analyses limited in patient numbers. Therefore, there still a lack of evidence for clinical decisions. In addition, the most recent TNM classification questionable; line with previous studies, we found that it has not improved prognosis estimation. Methods: We evaluated 297 patients from Germany, Russia, Portugal. Tissue samples 233 were...
Squamous penile cancer displays a rare human papillomavirus (HPV)-associated tumor entity. Investigations on the molecular pathogenesis of HPV-driven are impaired by rareness clinical specimens and, in particular, missing relevant cell culture models. Here, we identified HPV-positive lines that HPV16 oncoproteins control TP63 expression modulating critical regulators, while integration into open reading frame facilitates oncogene expression. The resulting feed-forward loop leads to elevated...
You have accessJournal of UrologyBladder Cancer: Invasive VI1 Apr 2018MP78-05 INVASION-ASSOCIATED MIRNAS S AS POSSIBLE DIAGNOSTIC BIOMARKERS OF MUSCLE INVASIVE BLADDER CANCER IN TUMOR TISSUES AND URINARY EXOSOMES Sophie Baumgart, Pascal Meschkat, Philipp Edelmann, Arndt Hartmann, Rainer Bohle, Alexey Pryalukhin, Joana Heinzelmann, Michael Stöckle, and Kerstin Junker BaumgartSophie Baumgart , MeschkatPascal Meschkat EdelmannPhilipp Edelmann HartmannArndt Hartmann BohleRainer Bohle...