A5005476626- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Global Maternal and Child Health
- COVID-19 Impact on Reproduction
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy-related medical research
- Obesity, Physical Activity, Diet
- Child and Adolescent Health
- Congenital Diaphragmatic Hernia Studies
- Mechanical Circulatory Support Devices
- Adipokines, Inflammation, and Metabolic Diseases
- Electrolyte and hormonal disorders
- Adolescent and Pediatric Healthcare
- Mosquito-borne diseases and control
University Hospital Bonn
2015-2025
University of Bonn
2014-2023
Klinik für Frauenheilkunde
2014-2022
University Medical Center
2022
Heinrich Heine University Düsseldorf
2022
Düsseldorf University Hospital
2022
Katholisches Klinikum Bochum
2022
University Hospital and Clinics
2022
Universitäts-Augenklinik Bonn
2018
University Hospital Frankfurt
2016
Background— Pregnant women with a mechanical heart valve (MHV) are at heightened risk of thrombotic event, and their absolute need for adequate anticoagulation puts them considerable bleeding and, some anticoagulants, fetotoxicity. Methods Results— Within the prospective, observational, contemporary, worldwide Registry Pregnancy Cardiac disease (ROPAC), we describe pregnancy outcome 212 patients an MHV. We compare 134 tissue 2620 other without prosthetic valve. Maternal mortality occurred in...
We report the maternal and foetal outcomes at birth after 6 months in a cohort of pregnant women with hypertrophic cardiomyopathy (HCM). Although most HCM tolerate pregnancy well, there is an increased risk obstetric cardiovascular complications.All entered into prospective worldwide Registry Pregnancy Cardiac disease (ROPAC) were included this analysis. The primary endpoint was major adverse event (MACE), which death, heart failure (HF), thrombo-embolic event, arrhythmia. Baseline outcome...
The current Zika virus (ZIKV) outbreak is associated with neurological malformations and disorders in neonates. Areas of increased incidence may overlap dengue-hyperendemic areas. ZIKV infection enhanced by antibodies against dengue (DENV) cell culture inbred mice. Sufficiently powered clinical studies or primate addressing the enhancement fetal after previous are not available. human placenta susceptible to vitro, but it unknown whether antibody-dependent occurs at placental barrier. Here...
Congenital lower urinary-tract obstruction (LUTO) is caused by anatomical blockage of the bladder outflow tract or functional impairment urinary voiding. About three out 10,000 pregnancies are affected. Although several monogenic causes have been defined, it unknown whether congenital LUTO has a cause. Exome sequencing in family with four affected individuals urethra identified rare nonsense variant (c.2557C>T [p.Arg853∗]) BNC2, encoding basonuclin 2, tracking over generations. Re-sequencing...
Glycogen storage disease type Ib (GSD Ib) is caused by biallelic variants in
The overall birth prevalence for congenital malformations of the central nervous system (CNS) among Europeans may be as high 1 in 100 live births. etiological factors remain largely unknown. aim this study was to detect causative copy number variations (CNVs) fetuses terminated pregnancies with prenatally detected isolated brain malformations.Array-based molecular karyotyping performed a cohort 35 CNS malformations. Identified putative disease-causing CNVs were confirmed using quantitative...
Abstract Background For healthy women entering birth after uneventful pregnancy, midwife-led models of care have the potential to reduce interventions and increase vaginal rate. In Germany, 98.4% are giving in consultant-led obstetric units. Alongside midwifery units (AMU) been established 2003. We compared outcome registered for planned AMU at our hospital with a matched group low-risk who gave standard during same period time. Methods used retrospective cohort study design. The consisted...
Background Syndromic brain malformations comprise a large group of anomalies with birth prevalence about 1 in 1,000 live births. Their etiological factors remain largely unknown. To identify causative mutations, we used whole‐exome sequencing (WES) aborted fetuses and children syndromic which chromosomal microarray analysis was previously unremarkable. Methods WES applied eight case‐parent trios, six fetuses, two children. Results identified novel de novo mutation (p.Gly268Arg) ACTB...
Early infant weight development influences metabolic regulation later in life. For the prevention of obesity and diseases, it is important to understand underlying mechanisms detail.This study aims examine effects maternal anthropometric, sociodemographic, lifestyle factors on cord blood leptin levels at birth body mass index (BMI) standard deviation scores (SDS) offspring up 1 year age.Seventy-six mother-child pairs were enrolled this follow-up analysis a cross-sectional design....
Complications of conservative management abnormal placentation in which the placenta is left situ for resorption include secondary hemorrhage, infection, and disseminated intravascular coagulation.A 41-year old woman received treatment percreta. Nine weeks after delivery, she developed gingival bleeding, easy bruising, moderate-to-severe vaginal bleeding. Hemostasis testing established diagnosis isolated hyperfibrinolysis; acute coagulation was excluded. Bleeding successfully treated using...
This study aimed to evaluate the diagnostic and prognostic value of cardiac magnetic resonance in acute peripartum cardiomyopathy (PPCM). A total 17 patients with PPCM stage 15 healthy controls were retrospectively analyzed regarding myocardial function, edema, late gadolinium enhancement (LGE), T1 T2 mappings (T1, T2). Echocardiographic follow-ups performed. Functional recovery was defined as a left ventricular ejection fraction (LVEF) ≥50%. Patients displayed biventricular dysfunction...