A5022838173- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatitis Pathology and Treatment
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Phagocytosis and Immune Regulation
- Granular flow and fluidized beds
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Apelin-related biomedical research
- Traumatic Brain Injury and Neurovascular Disturbances
- Influenza Virus Research Studies
- Clusterin in disease pathology
- RNA Research and Splicing
- Liver Diseases and Immunity
- Biomarkers in Disease Mechanisms
- Immune cells in cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Vitamin K Research Studies
- Advanced Glycation End Products research
Southeast University
2015-2023
Anhui Medical University
2021-2023
First Affiliated Hospital of Anhui Medical University
2021-2023
University of Liverpool
2017-2022
To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model patients with sepsis.Prospective, observational clinical study vivo ex translational laboratory investigations.General ICU university research laboratory.Sixty-five septic 27 healthy volunteers. Twelve-week-old male C57BL/6N mice.Serial blood samples from 65 sepsis were analyzed, left ventricular function was assessed by echocardiography. Patients' sera incubated cultured cardiomyocytes...
Multiple organ dysfunction syndrome is characterized by simultaneous multiple failure, which the leading cause of death in acute critically ill patients. However, what mediates not fully understood. The discovery toxic effects extracellular histones on different individual organs strongly suggests their involvement syndrome. In this study, we investigate whether circulating are major mediators critical illnesses.Combination retrospective clinical studies and animal models with...
Most patients who die of cancer do so from its metastasis to other organs. The calcium-binding protein S100A4 can induce cell migration/invasion and in experimental animals is overexpressed most human metastatic cancers. Here, we report that a novel inhibitor specifically block increase migration rat (IC50, 46 µM) (56 triple negative breast (TNBC) cells without affecting Western-blotted levels S100A4. moderately-weak S100A4-inhibitory compound, US-10113 has been chemically attached...
Extracellular histones are rapidly cleared by the liver and rarely detectable in circulation unless there is extensive cell death, as severe trauma sepsis. This study investigated whether circulating elevated experimental acute pancreatitis models correlate to disease severity.Acute was induced mice by: (1) 4 or (2) 12 intraperitoneal injections of cerulein (50 μg/kg) at 1 hour apart; (3) retrograde infusion 3.5% sodium taurocholate into biliopancreatic duct. Mice were sacrificed various...
Abstract Objectives Long non‐coding RNAs (LncRNAs) play an important role in hepatocellular carcinoma development, however, as a crucial driver of (HCC) metastasis, their functions tumour metastasis remain largely unknown. Materials and methods The lncRNA TRERNA1 expression levels were detected HCC by quantitative real‐time PCR (qPCR). function was examined wound‐healing assays, transwell assays tail vein injection experiments. potential regulatory mechanisms on its target genes explored...
Background and Objective . Chronic unexpected mild stress (CUMS) destroys synaptic plasticity of hippocampal regenerated neurons that may be involved in the occurrence poststroke depression. Astrocytes uptake glutamate at synapse provide metabolic support for neighboring neurons. Currently, we aim to investigate whether CUMS inhibits formation through a transporter, GLT-1, astrocytes ischemic stroke rats. Method We exposed rats ceftriaxone, during intervention period determine effects GLT-1...
Little is known about the effect of astroglial GLT-1 post-stroke depression (PSD) rat model on function neural stem cells (NSCs). This study aimed to investigate whether PSD rats affect differentiation NSCs from neonatal hippocampus and synaptic formation NSC-derived neurons. Astrocytes were isolated left normal adult SD rats. A lentiviral vector was used silence expression in astrocytes respectively co-cultured with (control), PSD, silenced for 7 days. GLT-1, GFAP, MAP2, Synaptophysin...
Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common causes more than one million deaths annually. Fibrosis develops from recurrent injury but the molecular mechanisms are not fully understood. Recently, TLR4-MyD88 signaling pathway has been reported contribute fibrosis. Extracellular histones ligands of TLR4 their roles in have investigated.
Multiple organ injury and dysfunction often occurs in acute critical illness adversely affects survival. However, patients who survive, function usually recovers without permanent damage. It is, therefore, likely that there are reversible mechanisms, but this is poorly understood the pathogenesis of multiple syndrome (MODS). Based on our knowledge extracellular histones pneumolysin, as endogenous exogenous pore-forming toxins, respectively, here we clarify if extent cell membrane disruption...
C-reactive protein (CRP) can increase up to 1000-fold in blood and form complexes with very low density lipoproteins (VLDL). These are associated worse outcomes for septic patients, this suggests a potential pathological role sepsis. Complex formation is heightened when CRP over 200 mg/l levels the severity of sepsis bacterial culture positivity. Using mouse bacteremia model, clearance be delayed by i.v. injection CRP-VLDL complexes. Complexes more efficiently taken activated U937 cells...
Neutrophils are the first line of defence against bacterial infection, and formation neutrophil extracellular traps (NETs) is an important protective mechanism. NETs can also be harmful by inducing intravascular coagulation multi-organ failure (MOF) in animal models.[1–6][1] Although
Objective To establish a mouse model of biliogenic severe acute pancreatitis (SAP) by using self-made device for retrograde injection sodium taurocholate into common bile duct, and to investigate the improvement on duct its safety. Methods Thirty-six adult male ICR mice were randomly divided SAP group sham group, with 18 in each group. A 40 U disposable insulin syringe, 200 μL tips 25 micro-syringer used as basic materials making [National Utility Model Patent (ZL 2014 2 0694365.4)]....
ABSTRACT BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common causes more than one million deaths annually. Fibrosis develops from recurrent injury but the molecular mechanisms are not fully understood. Recently, Toll-like receptor (TLR) 4-MyD88 signalling pathway has been reported contribute fibrosis. Extracellular histones ligands of TLR4 their roles in have investigated. AIM This study aims investigate potential extracellular METHODS In vitro, LX2...