A5086543492- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Immune cells in cancer
- T-cell and B-cell Immunology
- Environmental Toxicology and Ecotoxicology
- Immune Response and Inflammation
- Infant Nutrition and Health
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Circular RNAs in diseases
- Viral-associated cancers and disorders
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Nanoparticles: synthesis and applications
- Nanofabrication and Lithography Techniques
- Pharmacological Effects of Natural Compounds
- Nuclear Receptors and Signaling
- Ginseng Biological Effects and Applications
- Bone and Joint Diseases
- Diabetes and associated disorders
- Asthma and respiratory diseases
- Plant Water Relations and Carbon Dynamics
China Three Gorges University
2025
University of Macau
2023
Wuhan Academy of Agricultural Sciences
2023
Guangdong Academy of Medical Sciences
2022
Guangdong Provincial People's Hospital
2022
Jilin Province Tumor Hospital
2014-2021
Shaanxi Normal University
2021
Central South University
2011-2020
Second Xiangya Hospital of Central South University
2017-2020
University of Hong Kong
2020
MicroRNAs (miRNAs) are small noncoding RNAs that involved in various diseases, including cancer. In the present study, we found miR-216b was downregulated nasopharyngeal carcinoma (NPC) cell lines and specimens. Decreased expression of directly related to advanced clinical stage lymph node metastasis. levels correlated inversely with KRAS protein during tumorigenesis. Furthermore, demonstrated can bind 3′ untranslated region (UTR) inhibit protein. Both vitro vivo assays revealed attenuated...
Recognition of viral pathogen-associated molecular patterns by pattern recognition receptors (PRRs) is the first step in initiation a host innate immune response. As PRR, RIG-I detects either RNA or replication transcripts. Avoiding strategy employed viruses for evasion. Epstein-Barr virus (EBV) infects majority human population worldwide. During latent infection period there are only few EBV proteins expressed, whereas EBV-encoded microRNAs, such as BART highly expressed. microRNAs regulate...
Abstract Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about exact role regulation mechanism of lncRNA UCA1 during progression gastric (GC). In this study, we found was aberrantly elevated tissues, significantly associated with lymph node metastasis TNM stage. vivo vitro, enforced level promoted cell migration invasion GC cell. Depleted expression attenuated...
LTF (lactotransferrin, or lactoferrin) plays important role in innate immunity, and its anti-tumor function has also been reported multiple cancers. We previously that is significantly down-regulated nasopharyngeal carcinoma (NPC) acts as a tumor suppressor by suppressing AKT signaling. However, the exact mechanism of down-regulation NPC not revealed. In current study, we screened identified bona fide target miR-214 cells. mimics suppressed mRNA protein expression levels only can promote...
The c-Myc transcription factor regulates a complex transcriptional program that leads to cellular transformation by targeting large number of protein-encoding genes and non-coding RNAs. In this study, we show microRNA, miR-200c, is novel target promotes metastasis in nasopharyngeal carcinoma. MiR-200c achieves oncogenic effect, at least part, inhibiting the tumor suppressor gene PTEN (phosphatase tensin homolog), which key inhibitor AKT kinase signaling tumorigenesis Our study thus...
Abstract Genes associated with specific neurocognitive phenotypes in Williams–Beuren syndrome are still controversially discussed. This study identified nine patients atypical deletions out of 111 syndrome; these included seven smaller and two larger deletions. One patient had normal neurodevelopment a deletion genes on the distal side chromosomal region, including GTF2I GTF2IRD1 . However, another retained but showed neurodevelopmental abnormalities. By comparing genotypes typical previous...
Metformin, a widely prescribed antidiabetic agent, has been shown to exhibit anti-inflammatory effects in obese and type 2 diabetes patients, but the mechanism is not well elucidated. Microribonucleic acids (miRNAs) are group of small non-coding ribonucleic that participate many biological pathological processes. The aim present study was investigate whether Dicer, key miRNA biogenesis enzyme, miRNAs macrophages implicated metformin.
Abstract Objectives Long non‐coding RNAs (LncRNAs) play an important role in hepatocellular carcinoma development, however, as a crucial driver of (HCC) metastasis, their functions tumour metastasis remain largely unknown. Materials and methods The lncRNA TRERNA1 expression levels were detected HCC by quantitative real‐time PCR (qPCR). function was examined wound‐healing assays, transwell assays tail vein injection experiments. potential regulatory mechanisms on its target genes explored...
NK cells and αβ‐ γδ‐CTL play important roles in cellular immunity against tumors. We previously demonstrated that NPC patients have a quantitative qualitative deficit EBV‐specific αβ‐CTL when compared to normal subjects long‐term survivors. In this study we report further observations of complementary activation peripheral patients. The these patients, those healthy survivors, were preferentially activated response the stimulation myeloma cell line XG‐7 expanded presence exogenous IL‐2....
Statement of RetractionWe, the Editors and Publisher journal Cell Cycle, have retracted following article:Hong Gao, Xiaosong Sun, Hongdong Wang & Ying Zheng (2020) Long noncoding RNA SNHG22 increases ZEB1 expression via competitive binding with microRNA-429 to promote malignant development papillary thyroid cancer, 19:10, 1186-1199, DOI: 10.1080/15384101.2020.1749466Since publication, authors informed us they not been able replicate their results presented in this article. As casts doubt...
Grapes, an important and widespread fruit crop providing multiple products, face increasing flooding risks due to intense frequent extreme rainfall. It is thus imperative fully understand the flood-tolerance mechanisms of grapevines. Here, RNA-seq LC-MS/MS technologies were used analyze transcriptome metabolome changes in roots SO4 (tolerant flooding) Kyoho (sensitive grapes under post-flooding conditions. The results showed that abundance many metabolites phenylpropanoids polyketides,...
The increasing incidence of papillary thyroid cancer (PTC) has attracted many researchers to investigate the mechanism underlying PTC progression. This study explored growth and apoptosis cells based on an lncRNA regulatory mechanism. expression nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1) in cell lines tissues was analyzed by qRT-PCR. mutual binding site between NNT-AS1 miR-199a-5p predicted starBase confirmed dual-luciferase reporter assay. correlation shown Pearson...