A5100645711- PI3K/AKT/mTOR signaling in cancer
- Animal Genetics and Reproduction
- Renal and related cancers
- Ubiquitin and proteasome pathways
- Polyamine Metabolism and Applications
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Amino Acid Enzymes and Metabolism
- Pancreatic function and diabetes
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- interferon and immune responses
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Physiological and biochemical adaptations
- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- Cancer-related Molecular Pathways
- Reproductive biology and impacts on aquatic species
- Advanced Photocatalysis Techniques
Qingdao National Laboratory for Marine Science and Technology
2020-2025
Institute of Oceanology
2020-2025
Chinese Academy of Sciences
2020-2025
Jinan University
2025
Xinjiang Agricultural University
2024
Shandong Jiaotong University
2024
Shanghai Jiao Tong University
2024
Shanghai Artificial Intelligence Laboratory
2024
Inner Mongolia University
2014-2023
Xinxiang Medical University
2023
Mammalian spermatogenesis shows prominent chromatin and transcriptomic switches in germ cells, but it is unclear how such dynamics are controlled. Here we identify RNA helicase DDX43 as an essential regulator of the remodeling process during spermiogenesis. Testis-specific Ddx43 knockout mice show male infertility with defective histone-to-protamine replacement post-meiotic condensation defects. The loss its ATP hydrolysis activity by a missense mutation replicates phenotype global mice....
Triantennary N-acetyl galactosamine (GalNAc3) is a high-affinity ligand for hepatocyte-specific asialoglycoprotein receptors. Conjugation with GalNAc3 via trishexylamino (THA)-C6 cluster significantly enhances antisense oligonucleotide (ASO) potency. Herein, the biotransformation, disposition, and elimination of THA ION-681257, GalNAc3-conjugated ASO currently in clinical development, are investigated rats monkey. Rats were administered single subcutaneous dose (3)H-radiolabeled ((3)H placed...
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), wild-type mice. Wild-type DKO homozygous mice were administered a single subcutaneous injection of ION-353382 at 0, 5, 15, 30, 60 mg/kg. Mice sacrificed 72 h with plasma organs harvested. Both liquid chromatography-mass spectrometry (LC-MS)...
Nitrate (NO3−), a potential toxic nitrogenous compound to aquatic animals, is distributed in ecosystems worldwide. The aim of this study was investigate the effects different NO3− levels on growth performance, health status, and endocrine function juvenile turbot (Scophthalmus maximus) recirculating aquaculture systems (RAS). Fish were exposed 0 mg/L (control, CK), 50 (low nitrate, LN), 200 (medium MN), 400 (high HN) NO3-N for 60 d experimental RAS. Cumulative survival (CS) significantly...
Laminaria japonica is a large marine brown alga that annually highly productive. However, due to its underutilization, potential value substantially wasted. For example, lot of cellulose remains unused during production algin. The soluble dietary fiber (SDF) was prepared from the byproducts japonica, and physicochemical properties were explored. SDF exhibits good water-holding, oil-holding, water-absorbing swelling, glucose cholesterol absorption capacity, inhibitory activity α-amylase...
Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) regulate the production pro- anti-inflammatory cytokines that are induced by extrinsic antigens, but function mTORC1 in flagellin-induced response is unknown. The purpose this study was to examine role mechanism PI3K/Akt/mTOR pathway cytokine expression mouse macrophages. We observed upregulated TNF-α time- dose-dependently. Flagellin stimulated rapid (<15 min)...
Recirculating aquaculture systems (RAS) have promising applications in aquaculture. Feed is recognized as a major source of input to the RAS, and feeding frequency will not only impact performance turbot, but also quality cultured water. In order rationally manage reduce pollution, this study investigated effects on turbot (Scophthalmus maximus), nitrogen removal (ammonia nitrite) characteristics microbial communities biofilters. The experiment was designed with three treatment groups, which...
Abstract Background Right ventricular failure (RVF) is a major contributor to poor prognosis in patients with pulmonary arterial hypertension (PAH); however, its underlying molecular mechanisms remain incompletely understood. We identified significant upregulation of the cardiac fetal gene SND1 right myocardium RVF rats. This may be key component reprogramming and play critical role progression. However, precise by which contributes unelucidated. Methods Rat models PAH were established...
To explore the impact of a collaborative management for couples based on KING's Goal Attainment Theory health outcomes post-percutaneous coronary intervention (PCI) patients with heart disease (CHD). This RCT involved 194 eligible patients, randomly assigned to either control group or an group. The received routine care and follow-up, while Theory-based couple-focused case in addition care. comprised pre- post-discharge sessions, containing dyadic goal-setting strategies, fostering...