A5090746223- Bariatric Surgery and Outcomes
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Diabetes Treatment and Management
- Xenotransplantation and immune response
- Esophageal and GI Pathology
- Animal Genetics and Reproduction
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Virus-based gene therapy research
- Intestinal and Peritoneal Adhesions
- Body Contouring and Surgery
- Hernia repair and management
- Macrophage Migration Inhibitory Factor
- Nutrition and Health in Aging
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Immune Response and Inflammation
- Appendicitis Diagnosis and Management
- Diabetes and associated disorders
- Gastroesophageal reflux and treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Transplantation: Methods and Outcomes
- Pancreatic function and diabetes
- Circular RNAs in diseases
Xuzhou Medical College
2014-2024
Central South University
2024
Xiangya Hospital Central South University
2024
Huadong Hospital
2023
Fudan University
2023
Affiliated Hospital of Xuzhou Medical College
2014-2023
Creative Commons
2021
Second Affiliated Hospital of Nanjing Medical University
2020
Nanjing Drum Tower Hospital
2017
University of Pittsburgh Medical Center
2006-2011
Abstract Sleep disorders increase the risk and mortality of heart disease, but brain-heart interaction has not yet been fully elucidated. Cuproptosis is a copper-dependent type cell death activated by excessive accumulation intracellular copper. Here, we showed that 16 weeks sleep fragmentation (SF) resulted in elevated copper levels male mouse exacerbated myocardial ischemia–reperfusion injury with increased cuproptosis apoptosis. Mechanistically, found SF promotes sympathetic overactivity,...
Abstract Atg7 is an indispensable factor that plays a role in canonical nonselective autophagy. Here we show genetic ablation of outer hair cells (OHCs) mice caused stereocilium damage, somatic electromotility disturbances, and presynaptic ribbon degeneration over time, which led to the gradual wholesale loss OHCs subsequent early-onset profound hearing loss. Impaired autophagy disrupted OHC mitochondrial function triggered accumulation dysfunctional mitochondria would otherwise be...
Abstract: Background: The availability of pigs homozygous for α 1,3‐galactosyltransferase gene‐knockout (GT‐KO) has enabled study the incidence and cytotoxicity primate antibodies directed to antigens other than Gal 1,3Gal (Gal), termed non‐Gal antigens. Methods: Sera from 27 healthy humans 31 patients awaiting renal allotransplantation, who were either unsensitized [panel reactive (PRA) < 10%] or allosensitized (PRA > 70%), tested by flow cytometry binding immunoglobulin M (IgM) IgG...
Abstract: Background: As pigs homozygous for α 1,3‐galactosyltransferase gene‐knockout (GT‐KO) are available, primate antibodies to pig non‐Gal antigens can be studied. Methods: Sera from 56 baboons were tested binding of IgM and IgG peripheral blood mononuclear cells (PBMC) both wild‐type (WT) GT‐KO by flow cytometry. Complement‐dependent cytotoxicity was measured in 39 sera. Antibody responses two exposed a heart, one not immunosuppressed that received only cobra venom factor. Results:...
Peripheral nerve from experimentally diabetic rats exhibits lowered levels of myo-inositol (MI) and decreased incorporation [3H]MI into phosphatidylinositol (PI). There are indications that diminished PI turnover may be causally related to reduced Na+,K(+)-ATPase activity in nerve. We have investigated whether a metabolic compartment MI is essential for synthesis this tissue. Sciatic segments streptozotocin-induced age-matched normal were incubated vitro with either 32Pi or [3H]cytidine the...
Lgr5+ supporting cells (SCs) are enriched hair cell (HC) progenitors in the cochlea. Both vitro and vivo studies have shown that HC injury can spontaneously activate to regenerate HCs neonatal mouse Promoting regeneration requires understanding of mechanism regeneration, this knowledge key genes involved injury-induced self-repair responses promote proliferation differentiation progenitors. Here, as expected, we found neomycin-treated (NLPs) had significantly greater ability, but not...
Abstract Background Right ventricular failure (RVF) is a major contributor to poor prognosis in patients with pulmonary arterial hypertension (PAH); however, its underlying molecular mechanisms remain incompletely understood. We identified significant upregulation of the cardiac fetal gene SND1 right myocardium RVF rats. This may be key component reprogramming and play critical role progression. However, precise by which contributes unelucidated. Methods Rat models PAH were established...
Objectives: Streptozotocin (STZ) has been widely used to induce diabetes in rodents and nonhuman primates, but it found difficult achieve a completely diabetic state pigs the absence of detrimental side effects. As result, pancreatectomy advocated this species. We have investigated effects 2 dosages STZ safely pigs. Methods: Three received Zanosar at 150 mg/kg (group 1). Four 200 2). The levels glucose, insulin, C-peptide when (a) fasting, (b) 30 minutes after eating, (c) during intravenous...
Lysyl oxidase (LOX) initiates the enzymatic stage of collagen and elastin cross-linking. It also has intracellular functions involved in regulation cell differentiation, motility/migration gene transcription. Aberrant expression LOX been reported multiple tumors. However, correlation its with clinicopathological parameters prognostic significance gastric cancer remains largely unknown. In order to address this problem, total RNA paired tissue samples (n=10) a microarray containing 161...
Background: The aim of this study was to describe and analyze the current status diagnosis management acute appendicitis in China. Patients Methods: An online record system used collect data retrospectively from 52 medical centers mainland All patients with who were first treated at hospital 2017 included followed up for one year. Propensity score matching (PSM) exclude potential confounders difference outcomes between non-operative (NOM) surgical groups. Results: A total 10,187 enrolled,...