A5018079238- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pharmacological Effects and Toxicity Studies
- Viral gastroenteritis research and epidemiology
- Cardiac Arrest and Resuscitation
- Pregnancy and Medication Impact
- Organ Transplantation Techniques and Outcomes
- Statistical Methods in Clinical Trials
- Animal Virus Infections Studies
- Acute Myocardial Infarction Research
- Influenza Virus Research Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Epilepsy research and treatment
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- Air Quality and Health Impacts
- Statistical Methods and Inference
- Statistical Distribution Estimation and Applications
- Statistical Methods and Bayesian Inference
- Hepatitis Viruses Studies and Epidemiology
- Heart rate and cardiovascular health
- Pregnancy and preeclampsia studies
Université Paris-Saclay
2017-2025
Inserm
2014-2025
Université de Versailles Saint-Quentin-en-Yvelines
2015-2025
Centre de recherche en Epidémiologie et Santé des Populations
2012-2025
Université Paris-Sud
2010-2023
Institut Pasteur
2015-2020
Assistance Publique – Hôpitaux de Paris
2008-2020
Université Paris Cité
2008-2015
Sorbonne Paris Cité
2015
Délégation Paris 5
2009-2015
beta-Blockade-induced benefit in heart failure (HF) could be related to baseline rate and treatment-induced reduction, but no such relationships have been demonstrated.In CIBIS II, we studied the between (BHR), changes at 2 months (HRC), nature of cardiac rhythm (sinus or atrial fibrillation), outcomes (mortality hospitalization for HF). Multivariate analysis II showed that addition beta-blocker treatment, BHR HRC were both significantly survival worsening HF, lowest greatest being...
The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Data Network™ (GVDN®), facilitates comprehensive assessment of vaccine safety. This study aimed to evaluate risk adverse events special interest (AESI) following COVID-19 vaccination from 10 sites across eight countries. Using a common protocol, this observational cohort compared observed with expected rates 13 selected AESI neurological, haematological, and cardiac outcomes. Expected were obtained...
It is now widely accepted that haplotypic information can be of great interest for investigating the role a candidate gene in etiology complex diseases. In absence family data, haplotypes cannot deduced from genotypes, except individuals who are homozygous at all loci or heterozygous only one site. Statistical methodologies therefore required inferring genotypic data and testing their association with phenotype interest. Two maximum likelihood algorithms often used context haplotype-based...
The aim of this study was to assess the factors, including surgical portosystemic shunts, which affect survival in adults with Budd-Chiari syndrome. Multivariate retrospective analysis performed using characteristics recorded at time diagnosis 120 patients admitted from 1970 1992, whom 82 were treated shunts and 38 received only medical therapy. 1-, 5-, 10-year rates 77 ± 4%, 64 5%, 57 6%, respectively. Survival significantly better subgroup diagnosed after versus before 1985. In both...
Endothelin-1 is a potent vasoconstrictive and multifunctional peptide. Elevated concentrations have been reported in congestive heart failure. We hypothesized that the level of endothelin-1 plasma prognostic marker Plasma levels were measured by radioimmunoassay 120 failure patients with ischaemic or non-ischaemic cardiomyopathy (mean ejection fraction 28±11%, New York Heart Association (NYHA) functional class I: 21, II: 35, III: 61, IV: 3). During median follow-up 361±338 days, 14 cardiac...
Background To further evaluate the mechanism of β-blocker–induced benefits in heart failure, relationships between bisoprolol-induced hemodynamic effects and survival were studied during Cardiac Insufficiency BIsoprolol Study (CIBIS). Methods Results In 557 patients studied, bisoprolol significantly reduced rate (−16.3±15.3 versus −1.6±13.4 bpm, respectively; P <.001) compared with placebo at 2 months after inclusion study. Heart change over time had highest predictive value for (...
Background/objective: Little is known on the morphological changes in kidneys of cirrhotic patients with abnormal urinalysis and/or high serum creatinine levels. This retrospective, one-point-in-time study aimed to report results analysis renal biopsy specimens obtained cirrhosis. Methods: We retrieved information 65 who underwent transvenous for proteinuria >0.5 g/day microscopic haematuria unexplained impairment (defined by levels >1.5 mg/dl). Results: Fifty-one per cent had g/day, 58% and...
To determine if female gender is an independent predictor of in-hospital mortality after percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction (STEMI). A higher early rate STEMI has been reported in women before the widespread use PCI STEMI. improves prognosis STEMI, however, effect this setting controversial. In a large regional prospective registry, we examined STEMI.The greater Paris area comprises 11 million inhabitants. Data from all PCIs performed 41...
World records (WR) in sports illustrate the ultimate expression of human integrated muscle biology, through speed or strength performances. Analysis and prediction man's physiological boundaries impact external (historical environmental) conditions on WR occurrence are subject to scientific controversy. Based analysis 3263 established for all quantifiable official contests since first Olympic Games, we show here that progression rate follows a piecewise exponential decaying pattern with very...
The Global COVID Vaccine Safety (GCoVS) project was established in 2021 under the multinational Data Network (GVDN) consortium to facilitate rapid assessment of safety newly introduced vaccines. This study analyzed data from GVDN member sites on background incidence rates conditions designated as adverse events special interest (AESI) for COVID-19 vaccine monitoring.Eleven global obtained national or regional healthcare databases using standardized methods. Incident 13 pre-defined AESI were...
ABSTRACT In vitro activities of 17 antibiotics against 53 clinical strains Mycobacterium marinum , an atypical mycobacterium responsible for cutaneous infections, were determined using the reference agar dilution method. Rifampin and rifabutin most active drugs (MICs at which 90% isolates tested inhibited [MIC 90 s], 0.5 0.6 μg/ml, respectively). MICs minocycline (MIC 4 μg/ml), doxycycline 16 clarithromycin sparfloxacin 2 moxifloxacin 1 imipenem 8 sulfamethoxazole μg/ml) amikacin close to...
The feasibility of spirometry or respiratory impedance measurements for assessing lung function in the elderly was compared 208 institutionalized patients with various degrees cognitive impairment. Respiratory determined by forced oscillation technique. Cognitive assessed score mini-mental state (MMS) examination. Of patients, 126 had severe impairment (MMS < = 17), 36 mild (18 MMS 23), and 46 no > 24). were possible 159, whereas only 85 possible. overall difference between rates spirometric...
Several prognostic indices (PIs) have been proposed for Budd-Chiari syndrome (BCS). However, patient characteristics, causal factors, and treatment outcomes changed since these elaborated. Validation in a recent population comparison of predictive accuracy between PIs are needed.A database 96 BCS patients diagnosed 1995 2005 was analyzed. Cox survival models were fitted with time to liver transplantation or death, invasive therapy as end points. The values known (Child-Pugh score, model...
The growth law for the development of top athletes performances remains unknown in quantifiable sport events. Here we present a model 41351 best performers from 70 track and field (T&F) swimming events detail their characteristics over modern Olympic era. We show that 64% T&F no longer improved since 1993, while 47% stagnated after 1990, prior to second progression step starting 2000. Since then, 100% continued progress. also provide measurement atypicity 3919 (BP) each year every event....
Abstract Background Statins represent candidates for drug repurposing in Parkinson's disease (PD). Few studies examined the role of reverse causation, statin subgroups, and dose–response relations based on time‐varying exposures. Objectives We whether use is associated with PD incidence while attempting to overcome limitations described previously, especially causation. Method used data from E3N cohort study French women (follow‐up, 2004–2018). Incident was ascertained using multiple sources...