A5027760604- Blood groups and transfusion
- Plant Disease Resistance and Genetics
- Systemic Lupus Erythematosus Research
- Mycotoxins in Agriculture and Food
- Erythrocyte Function and Pathophysiology
- Wheat and Barley Genetics and Pathology
- MicroRNA in disease regulation
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Folate and B Vitamins Research
- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Plant Micronutrient Interactions and Effects
- Phytase and its Applications
- Lanthanide and Transition Metal Complexes
- Hepatitis B Virus Studies
- Agriculture, Soil, Plant Science
- Renal Transplantation Outcomes and Treatments
- Nanoparticle-Based Drug Delivery
- Drug-Induced Adverse Reactions
- Circular RNAs in diseases
- Platelet Disorders and Treatments
- Topic Modeling
- Biopolymer Synthesis and Applications
- Carcinogens and Genotoxicity Assessment
Chiang Mai University
2015-2024
Maharaj Nakorn Chiang Mai Hospital
2015-2017
Kasetsart University
2013
University of Nottingham
2010
Nanopore sequencing has been examined as a method for rapid and high-resolution human leukocyte antigen (HLA) typing in recent years. We aimed to apply ultrarapid nanopore-based HLA class I alleles associated with drug hypersensitivity, including HLA-A*31:01, HLA-B*15:0 2 , HLA-C*08:01. Most studies have used the Oxford Ligation Sequencing kit typing, which requires several enzymatic reactions remains relatively expensive, even when samples are multiplexed. Here, we Rapid Barcoding kit, is...
Cell-based therapy is a highly promising treatment paradigm in ischemic disease due to its ability repair tissue when implanted into damaged site. These therapeutic effects involve strong paracrine component resulting from the high levels of bioactive molecules secreted response local microenvironment. Therefore, can be modulated by preconditioning cells during vitro culturing. Herein, we investigated potential use magnetic resonance imaging (MRI) probes, “iron–quercetin complex” or IronQ,...
Abstract In plants, polyglutamylated folate forms account for a significant proportion of the total pool. Polyglutamylated are produced by enzyme folylpolyglutamate synthetase (FPGS). The FPGS is encoded two genes in rice, Os03g02030 and Os10g35940. represents major expressed form developing seed. To determine function this gene T-DNA knockout line was characterised. Disrupting expression resulted delayed seed filling. LC-MS/MS-based metabolite profiling revealed that abundance mono-...
The theranostic agent iron-quercetin complex (IronQ) provides a T1-positive magnetic resonance imaging (MRI) contrast agent. magnetically IronQ-labeled cells can be used for cell tracking and have active biological applications in promoting tissue regeneration. However, detailed investigation of IronQ's cytotoxicity genotoxicity is necessary. Thus, this study aimed to evaluate the possibility IronQ inducing peripheral blood mononuclear (PBMCs). We evaluated vitality cells, production...
Purpose To determine the frequency and association of alleles at human leukocyte antigen (HLA)-DRB1 HLA-DQB1 loci in VKH disease patients from Northern Thailand.Methods A case–control study was conducted with three subject groups: 23 patients, 20 other uveitis entities, 40 healthy blood donors. HLA-DRB1 were analyzed calculated by direct counting. The measure odds ratio (OR) 95% confidence interval.Results In most prevalent allele HLA-DRB1*04:05, found 35% highest OR (42.13). HLA-DQB1*04:01...
Abstract Peripheral blood is an alternative source of stem/progenitor cells for regenerative medicine owing to its ease retrieval and bank storage. Previous in vitro studies indicated that the conditioned medium derived from peripheral mononuclear (PBMCs) treated with iron–quercetin complex (IronQ) contains potent angiogenesis wound-healing properties. This study aims unveil intricate regulatory mechanisms governing effects IronQ on transcriptome profiles human PBMCs healthy volunteers those...
Abstract Background: Cells-based therapy is a highly promising treatment paradigm in ischemic disease due to its ability repair tissues when implanted into damaged site. These therapeutic effects have been involving strong paracrine component resulting from the high levels of bioactive molecules they secrete response local microenvironment. Therefore, secreted can be modulated by preconditioning cells during vitro culture. Herein, we investigated potential use magnetic resonance imaging...
Major characteristics of the para-Bombay phenotype are absence ABH antigens on red blood cells due to fucosyltransferase 1 (FUT1) gene mutation and presence these in body secretions active 2 (FUT2) gene. An ABO group discrepancy can be identified via serological testing, additional tests performed for confirmation. This study aimed resolve report two novel alleles FUT2 northern Thai families.Twelve samples were collected from five suspected donors their families. Nucleotide sequences ABO,...
Precise identification is needed to avoid the transfusion reaction leading death from ABO incompatibility. However, some rare blood groups including subgroups, paraBombay or Bombay phenotypes may show weak no agglutination resulting in misidentification. Genotyping a method of choice which can identify group allele level. Although DNA sequencing medium-throughput technique, it time-consuming and large data generated. In this work, analysis framework was proposed objected provide reliable...
Mixed-field agglutination (MFA) can be observed in forward typing of samples from A3 individuals with serologic ABO methods. The results column testing (CAT) and tube using different antibody clones discordant. In this report, we reveal our experience polymerase chain reaction-sequence-based (PCR-SBT) exon 7 to clarify method discordance A subgroup blood Northern Thai donors. total 21 group donors either MFA or weak on routine CAT were recalled. was repeated human monoclonal anti-A, anti-A...
This paper proposed a knowledge base of blood group phenotyping. The was designed to identify groups and ABO discrepancy screening. These procedures are very important for transfusion. incompatible in transfusion may result haemolytic reactions. severity can range from no symptom death. In the study, on phenotyping gathered trust sources. developed using ontology engineering concepts represented Resource Description Framework (RDF) graph. structure data, or schema stored Turtle Ontology Web...
Analysis of blood group characteristics using next-generation sequencing can be used to ensure transfusion safety. With the aim avoiding adverse effects in transfusions caused by incompatibility, this research studies genomic groups whole-exome analysis. Whole-Exome Sequencing, although time-consuming and data-intensive, provides crucial information for The proposes a two-step analysis framework including WES raw data pipeline GATK, resulting single nucleotide polymor-phisms variant ABO...
In precision medicine, multiple factors are involved in clinical decision‑making because of ethnic and racial genetic diversity, family history other health factors. Although advanced techniques have evolved, there is still an economic obstacle to pharmacogenetic (PGx) implementation developing countries. The aim the present study was provide alternative pipeline that roughly estimate patient carrier type prescreen out wild‑type samples before sequencing or genotyping determine status. Fast...