A5002127648- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- Immunodeficiency and Autoimmune Disorders
- Renal and related cancers
- DNA Repair Mechanisms
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cancer Immunotherapy and Biomarkers
- Iron Metabolism and Disorders
- Breast Cancer Treatment Studies
- Genomics and Rare Diseases
- Connective tissue disorders research
- Mycobacterium research and diagnosis
- T-cell and B-cell Immunology
- Renal cell carcinoma treatment
- Colorectal Cancer Screening and Detection
- Genetic Syndromes and Imprinting
- Genetic and Kidney Cyst Diseases
- Ferroptosis and cancer prognosis
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
Siriraj Hospital
2010-2025
Mahidol University
2010-2025
ORCID
2023
Weatherford College
2023
National Cancer Institute of Thailand
2023
Medical Genetics Center
2014-2023
Genomics (United Kingdom)
2023
Meenakshi Mission Hospital and Research Centre
2019
Oita University
2019
Kyushu University Hospital
2019
Colorectal cancers (CRC) with KRAS mutations (KRASmut) are frequently included in consensus molecular subtype 3 (CMS3) profound metabolic deregulation. We explored the transcriptomic impact of KRASmut, focusing on tumor microenvironment (TME) and pathways beyond The status KRASmut patients CRC was investigated overall survival (OS) compared wild-type (KRASwt). Next, we identified CMS, further differentially expressed genes (DEG) distinctive pathways. Lastly, used spatially resolved gene...
Summary Lack of diversity and proportionate representation in genomics datasets databases contributes to inequity healthcare outcomes globally 1,2 . The relationships human with biological biomedical phenotypes are pervasive 3 , yet remain understudied, particularly a single-cell context. Here we present the Asian Immune Diversity Atlas (AIDA), multi-national RNA-sequencing (scRNA-seq) healthy reference atlas immune cells. AIDA comprises 1,265,624 circulating cells from 619 donors 6...
Recently a newly identified clinical syndrome of disseminated non-tuberculous mycobacterial diseases (with or without other opportunistic infections in adult patients who were previously healthy, has been recognized association with an acquired autoantibody to interferon-gamma. This is emerging as important cause morbidity and mortality, especially among people Asian descent. Trigger for the production this remains unknown, but genetic factors are strongly suspected be involved. We compared...
Several X-linked genes escape from X chromosome inactivation (XCI), while differences in across cell types and tissues are still poorly characterized. Here, we developed scLinaX for directly quantifying relative gene expression the inactivated with droplet-based single-cell RNA sequencing (scRNA-seq) data. The differentially expressed analyses large-scale blood scRNA-seq datasets consistently identified stronger lymphocytes than myeloid cells. An extension of to a 10x multiome dataset...
Background Clinical courses and treatment outcomes are largely unknown in patients with adult-onset immunodeficiency associated anti-interferon-gamma autoantibodies due to the fact that it was recently recognized anti-IFN-γ auto-Abs detection is not widely available. Methods findings Non-HIV-infected adult detectable diagnosed followed at Siriraj Hospital, Bangkok, Thailand during January 2013 November 2016 were prospectively studied. At each follow-up visit, classified as stable or active...
The incidence of colorectal cancer (CRC) in young adults has increased worldwide. Our study aimed to evaluate genomic alterations early-onset (aged 15–39 years) sporadic CRC. Formalin-fixed, paraffin-embedded tissue samples from 90 patients with histologically confirmed adenocarcinoma proficient mismatch repair status Siriraj Hospital (Bangkok, Thailand) were extracted. Patients clinically suspected familial adenomatous polyposis excluded. A 517-gene mutational analysis was performed by...
Application of machine learning (ML) on cancer-specific pharmacogenomic datasets shows immense promise for identifying predictive response biomarkers to enable personalized treatment. We introduce CAN-Scan, a precision oncology platform, which applies ML next-generation generated from freeze-viable biobank patient-derived primary cell lines (PDCs). These PDCs are screened against 84 Food and Drug Administration (FDA)-approved drugs at clinically relevant doses (Cmax), focusing colorectal...
The clinical syndrome of disseminated nontuberculous mycobacterial (NTM) infection in patients who were previously healthy is now well recognized to be associated with an acquired autoantibody Interferon gamma (Anti IFN- γ autoantibody). However, the risk factors this remain unknown.We performed unmatched case control study among NTM diseases diagnosed and treated at Siriraj Hospital, Bangkok, Thailand. Anti-IFN was detected by enzyme-linked immunosorbent assay (ELISA) method. Cases...
Triple negative breast cancer (TNBC) is a subtype characterized by absence of both hormonal receptors and human epithelial growth factor receptor 2 (HER2). TNBC accounts for 15-20% cancer. associated with more aggressive disease worse clinical outcome. Though the underlying mechanism currently unclear, heterogeneity characteristics in various population may relate to difference tumor mutational profile. There were studies on gene mutations ethnic groups but genome data Thai patients unknown....
Abstract Background Food frequency questionnaires (FFQ) are a useful dietary assessment tool to determine relationships between diet and non-communicable diseases (NCDs). Our purpose was validate semiquantitative FFQ (semi-FFQ) for Thais at risk of metabolic syndrome (MS). Methods The researchers identified 345 men women aged 30–65 years who were eligible the study. Ninety-four participants finally enrolled (54 in “urine-collection not-required” group 40 “urine collection” group). They asked...
Nanopore sequencing has been examined as a method for rapid and high-resolution human leukocyte antigen (HLA) typing in recent years. We aimed to apply ultrarapid nanopore-based HLA class I alleles associated with drug hypersensitivity, including HLA-A*31:01, HLA-B*15:0 2 , HLA-C*08:01. Most studies have used the Oxford Ligation Sequencing kit typing, which requires several enzymatic reactions remains relatively expensive, even when samples are multiplexed. Here, we Rapid Barcoding kit, is...
Abstract Multi-gene panel testing has led to the detection of pathogenic/likely pathogenic (P/LP) variants in many cancer susceptibility genes patients with breast-ovarian spectrum. However, clinical and genomic data Asian populations, including Thai patients, was underrepresented, significance multi-gene Thailand remains undetermined. In this study, we collected genetic from 4567 hereditary (HBOC) spectrum who underwent testing. Six hundred ten individuals (13.4%) had germline P/LP...