A5069201034- Endoplasmic Reticulum Stress and Disease
- Acupuncture Treatment Research Studies
- Receptor Mechanisms and Signaling
- Complementary and Alternative Medicine Studies
- Autophagy in Disease and Therapy
- Pain Management and Placebo Effect
- Protein Kinase Regulation and GTPase Signaling
- Neuroendocrine Tumor Research Advances
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Machine Learning in Materials Science
- Fungal and yeast genetics research
- Mitochondrial Function and Pathology
- Psychosomatic Disorders and Their Treatments
- Trace Elements in Health
- Cellular transport and secretion
- Sphingolipid Metabolism and Signaling
- Paranormal Experiences and Beliefs
- RNA regulation and disease
- PI3K/AKT/mTOR signaling in cancer
- Biochemical and Molecular Research
- Heat shock proteins research
- Iron Metabolism and Disorders
- CRISPR and Genetic Engineering
- Enzyme Structure and Function
Natural Resources Canada
2022-2024
National Physical Laboratory
2022
Korea Research Institute of Standards and Science
2022
Royal Military College of Canada
2009-2020
Vance Thompson Vision
2016
Creighton University
2015
McGill University
1997-2008
Institute of Cell Biology and Neurobiology
2007
McGill University Health Centre
2002-2003
Royal Victoria Hospital
1993-1999
Extensive efforts to gather materials data have largely overlooked potential redundancy. In this study, we present evidence of a significant degree redundancy across multiple large datasets for various material properties, by revealing that up 95% can be safely removed from machine learning training with little impact on in-distribution prediction performance. The redundant is related over-represented types and does not mitigate the severe performance degradation out-of-distribution samples....
Using a combination of polymerase chain reaction and genomic library screening we have cloned human gene for subtype the somatostatin (SST) receptor (SSTR) termed SSTR5 (hSSTR5), which is located on chromosome 16. The predicted amino acid sequence hSSTR5 displays 75% identity with recently identified rat SSTR [Mol. Pharmacol. 42:939-946 (1992)], suggesting that it homologue this receptor. consists 363-residue polypeptide exhibiting putative seven-transmembrane domain topology typical G...
To characterize cell specific expression of sstr subtypes in the pituitary we have analyzed mRNA for sstr1-5 rat somatotrophs by reverse transcriptase polymerase chain reaction and determined pattern level 2 5 individual subpopulations double label situ hybridization. Purified expressed all sstrs. In hybridization analysis revealed sstr5 70% somatotrophs, 57% thyrotrophs, 38% corticotrophs, 33% lactotrophs, 21% gonadotrophs. sstr2 occurred 40% 36% 26% 3% 8% Not only were more cells positive...
Synchronous populations of Saccharomyces cerevisiae cells, generated by two independent methods, have been used to show that thymidylate synthase, in contrast the vast majority cellular proteins thus far examined, fluctuates periodically during S. cell cycle. The enzyme, as assayed different accumulated S period and peaked mid late phase, then its level dropped. These observations suggest both periodic synthesis instability enzyme contribute activity profile seen Accumulation synthase is...
Aging | doi:10.18632/aging.100547. Vincent R. Richard, Anna Leonov, Adam Beach, Michelle T. Burstein, Olivia Koupaki, Alejandra Gomez-Perez, Sean Levy, Lukas Pluska, Sevan Mattie, Rami Rafeh, Tatiana Iouk, Sara Sheibani, Michael Greenwood, Hojatollah Vali, Vladimir I. Titorenko
The pattern of expression somatostatin receptor (SSTR) genes and gene products inAtT-20 cells was characterized in an attempt to explain the SST-28 binding selectivity that typifies these cells.AtT-20 expressed multiple SSTR mRNAs.Paradoxically, this included mRNA for three four SST-14 selective receptors: SSTR2 (++++), SSTRl (+), SSTRA (+).The SSTR5 as a 3.8-kilobase (kb) transcript relatively low abundance (+) contrast normal mouse pituitary which displayed high levels (+++) 2.4-kb...
Expression of human Bax, a cardinal regulator mitochondrial membrane permeabilization, causes death in yeast. We screened cDNA library for suppressors Bax-mediated yeast and identified 14-3-3β/α, protein whose paralogs have numerous chaperone-like functions. Here, we show that, cells expressing 14-3-3β/α are able to complement deletion the endogenous 14-3-3 confer resistance variety different stresses including cadmium cycloheximide. The expression also conferred induced by target rapamycin...
Generalization performance of machine learning models: (upper panel) generalization from small ordered to large disordered structures (SQS); (lower low-order high-order systems.
We identified a form of cell death called "liponecrosis." It can be elicited by an exposure the yeast Saccharomyces cerevisiae to exogenous palmitoleic acid (POA). Our data imply that liponecrosis is: (1) programmed, regulated rather than accidental, unregulated cellular process and (2) age-related death. Cells committed liponecrotic death: do not exhibit features characteristic apoptotic death; display plasma membrane rupture, hallmark programmed necrotic (3) akin cells death, increased...
We have identified mouse sphingomyelin synthase 1 as a novel suppressor of the growth inhibitory effect heterologously expressed Bax. Yeast cells expressing were also found to show an increased resistance variety cytotoxic stimuli including hydrogen peroxide, osmotic stress and elevated temperature. Sphingomyelin functions by catalyzing conversion ceramide phosphatidylcholine diacylglycerol. Ceramide is antiproliferative proapoptotic sphingolipid whose level increases in response stresses....
Synchronous populations of Saccharomyces cerevisiae cells, generated by two independent methods, have been used to show that thymidylate synthase, in contrast the vast majority cellular proteins thus far examined, fluctuates periodically during S. cell cycle. The enzyme, as assayed different accumulated S period and peaked mid late phase, then its level dropped. These observations suggest both periodic synthesis instability enzyme contribute activity profile seen Accumulation synthase is...