A5101550209- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Natural product bioactivities and synthesis
- Colorectal Cancer Treatments and Studies
- Myofascial pain diagnosis and treatment
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Pharmacological Effects of Natural Compounds
- Bioactive natural compounds
- Colorectal Cancer Surgical Treatments
- Vestibular and auditory disorders
- Musculoskeletal pain and rehabilitation
- Cancer-related Molecular Pathways
- Phytochemistry and Biological Activities
- Receptor Mechanisms and Signaling
- Proteoglycans and glycosaminoglycans research
- Colorectal and Anal Carcinomas
- Pain Mechanisms and Treatments
- Phytochemical compounds biological activities
- Acupuncture Treatment Research Studies
- Planarian Biology and Electrostimulation
- Phytochemistry and Bioactivity Studies
- Occupational Health and Performance
- Synthesis of Organic Compounds
- Hepatocellular Carcinoma Treatment and Prognosis
The First People's Hospital of Guiyang
2021-2023
Huadong Hospital
2015-2022
Fudan University
2016-2022
Zhejiang Cancer Hospital
2018-2020
Zhejiang Chinese Medical University
2018-2020
Cancer Hospital of Chinese Academy of Medical Sciences
2019-2020
Chinese Academy of Sciences
2020
University of Chinese Academy of Sciences
2019
Yueyang Hospital
2018
Shanghai University of Traditional Chinese Medicine
2018
Overexpression of the multifunctional growth factor transforming factor-beta 1 (TGF beta 1) has been connected to numerous diseases in human. TGF expression is largely governed by three AP-1 binding sites located two different promoters this gene. We have examined ability retinoid receptors inhibit activity (especially promoter cotransfection assays hepatocellular carcinoma cell line HepG2. When induced 12-O-tetradecanoyl phorbol13-acetate (an activator AP-1-controlled gene transcription),...
Abstract Objectives Long non‐coding RNAs (lncRNAs) are emerging RNA regulators in cancer progression, including hepatocellular carcinoma (HCC). Recently, insufficient radiofrequency ablation (RFA) has been reported to lead recurrence and metastasis of residual HCC tumours. Herein, we aimed the role ASMTL‐AS1 after RFA. Materials methods In vitro RFA model was simulated Huh7 cells subsequently named Huh7‐H cells. vivo assays were conducted investigate function HCC. Results LncRNA low...
Circular RNAs (circRNAs) have been reported that can be used as biomarkers for colorectal cancers (CRC) and other types of tumors. However, a limited number studies performed investigating the potential role circRNAs in tumor metastasis. Here, we examined two CRC cell lines (a primary SW480 its metastasis SW620), found large set circRNA (2,919 ncDECs) with significantly differential expression patterns relative to normal cells (NCM460). In addition, uncovered 623 pmDECs differ between cells....
The COUP transcription factors (COUP-TF and ARP-1) are the most highly conserved members of nuclear receptor superfamily throughout evolution. Previous studies indicated that orphan receptors may be involved in early neurogenesis Drosophila zebrafish. Here we identified a neural-specific gene, arrestin, whose can regulated by endogenous COUPs through DR-7 element (direct repeat with 7-base pair spacer) located upstream start site. Importantly, binding site arrestin gene promoter is among...
Nowadays, chemotherapy is still the main effective treatment for cancer. Herb prescriptions containing Pogostemon cablin Benth (also known as “Guang-Huo-Xiang”) have been widely used in Chinese medicine today. In our research, we found that patchouli alcohol, a compound isolated from oil of , exerted antitumor ability against human lung cancer A549 cells both vitro and vivo . MTT assay was to assess cell viability. Hoechst 33342 staining TUNEL cover glass provided visual evidence apoptosis....
Standard treatment options for brain metastases (BM) from colorectal cancer (CRC) are controversial. The purpose of this study was to evaluate the efficacy multidisciplinary modalities and provide optimal therapeutic strategies selected patients with different clinical characteristics. All eligible diagnosed BM CRC during past two decades (1997-2016) were identified in our center. Clinical characteristics, relative survival retrospectively analyzed. Median overall after identification 6...
Corydalis yanhusuo, a well-known herbaceous plant, is commonly used in the treatment of inflammation, injury and pain. One natural agent isolated from 13-methyl-palmatrubine, was found to have cytotoxic effect on cancer cells as reported published studies. In present study, we synthesized potential anti-lung tumor agent, 13-methyl-palmatrubine analyzed its activity. 13-Methyl-palmatrubine exhibited panel cell lines time- concentration-dependent manner. Among all tested lines, lung A549 were...
Knee Osteoarthritis is one of the most common diseases elder worldwide. Qi-Fang-Xi-Bi-Granules (QFXBG) a new Chinese medicine granules employed for treatment Osteoarthritis. Fangchinoline (FAN) and tetrandrine (TET) are used as targets quality control QFXBG. A simple, practical high-performance liquid chromatographic method was developed simultaneous quantitation FAN TET in Stephaniae tetrandrae radix The analysis performed on Athena C18 column (250 × 4.6 mm, 5 µm) with mobile phase...
Toonaciliatin K is a natural limonoid purified from the Toona ciliata Roem. var. (Meliaceae). This study to reveal inflammatory suppression effect of toonaciliatin and further intrinsic mechanism. Firstly, anti-inflammatory was evaluated in lipopolysaccharide- (LPS-) induced RAW264.7 cells. RT-PCR results indicated that mRNA expressions TNF-α, IL-6, IL-1β were downregulated by K. The inhibited levels stimulated LPS. Furthermore, LPS elicited excess iNOS COX-2 protein production attenuated...
Background: The objective of this study was to evaluate the prognostic value variation in tumor regression grade (TRG) and peritumoral lymphocytic infiltration colorectal liver metastases (CRLMs) after neoadjuvant chemotherapy (NACT). Methods: A retrospective review performed 98 patients with CRLMs who underwent NACT between 2010 2016. TRG scores counts TILs at tumor-normal interface were assessed all 176 resected determine their association prognosis. According scores, 40 more than one...
Background: Syndecan-2 (Sdc2) can affect the behavior of some cancer cells. However it is poorly understood in terms its role tumorigenesis gastric carcinoma. The present study was undertaken to explore expression and prognostic Sdc2 patients with adenocarcinoma tissue, effect on vitro.Methods: 46 tissue samples analyzed by immunohistochemistry. We evaluated clinical characteristics survival time. carcinoma cell lines confirmed real time polymerase chain reaction (RT-PCR) western blot. Cell...