A5051621958- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Phosphodiesterase function and regulation
- HER2/EGFR in Cancer Research
- Stress Responses and Cortisol
- Metabolomics and Mass Spectrometry Studies
- Cannabis and Cannabinoid Research
- Folate and B Vitamins Research
- Diabetes and associated disorders
- Cancer Genomics and Diagnostics
- Neonatal Health and Biochemistry
- Intestinal Malrotation and Obstruction Disorders
- Genetic factors in colorectal cancer
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Molecular Biology Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Lipoproteins and Cardiovascular Health
- Amino Acid Enzymes and Metabolism
- Genetic Associations and Epidemiology
Royal College of Surgeons in Ireland
2008-2021
University College Dublin
2009
Science Foundation Ireland
2005
Temple Street Children's University Hospital
2003-2004
St. Vincent's Hospital
1992
Abstract Neuregulin‐1 (NRG1) has been shown to play a role in glutamatergic neurotransmission and is risk gene for schizophrenia, which there evidence hypoglutamatergic function. Sensitivity the behavioural effects of psychotomimetic N ‐methyl‐ d ‐aspartate receptor antagonists MK‐801 phencyclidine (PCP) was examined mutant mice with heterozygous deletion NRG1. Social behaviour (sociability, social novelty preference dyadic interaction), together exploratory activity, assessed following...
The neuregulin-1 gene is widely expressed in the central nervous system and associated with increased risk for schizophrenia. Using an ethologically based approach, phenotype of heterozygous knockout mice was examined by revealing individual elements behaviour murine repertoire over prolonged course interaction environment. During initial exploration, mutants displayed a characterized increases locomotion rearing free, sex-specific alterations sifting grooming. Over subsequent habituation,...
Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of dopamine and disturbance function proposed to be central pathogenesis schizophrenia. Clinical epidemiological studies have indicated cannabis use confer a 2-fold increase risk for subsequent onset psychosis, with adolescent-onset conveying even higher risk. There evidence that high activity COMT polymorphism moderates effects adolescent exposure on adult psychosis. In this paper we compared effect chronic...
We have used serial analysis of gene expression (SAGE) to identify differences between a primary colon tumour cell line (SW480) and an isogenic lymph-node metastasis (SW620). Differential was confirmed for the following genes: keratin K5, cystatin S, serum amyloid A, human homologue yeast ribosomal S28 p32 subunit pre-mRNA splicing factor SF2. Expression were also analysed in other metastatic lines. © 2000 Cancer Research Campaign
To clarify the involvement of dopamine D4 receptors in behavioral regulation, phenotypic ethogram congenic "knockout" mice was studied terms (i) course exploration and habituation, (ii) topographical responsiveness to selective D2-like agonist RU 24213 D1-like agonists A 68930, SK&F 83959 83822. Congenic knockouts were characterized by a small reduction exploratory sniffing with delayed habituation sifting. The magnitude specificity these effects indicated that any functional role for...
Abstract Few studies have addressed likely gene × (ie, epistatic) interactions in mediating risk for schizophrenia. Using a preclinical genetic approach, we investigated whether simultaneous disruption of the factors Neuregulin-1 (NRG1) and Disrupted-in-schizophrenia 1 (DISC1) would produce disease-relevant phenotypic profile different from that observed following to either alone. NRG1 heterozygotes exhibited hyperactivity prepulse inhibition, both reversed by antipsychotic treatment,...
Abstract Uncertainty as to the functional role of D 3 dopamine receptor, due primarily a paucity selective agonists or antagonists, is being addressed in mice with targeted gene deletion (“knockout”) thereof. This study describes, for first time, phenotype congenic ‐null mice. Initially, 129/Sv × C57BL/6 were backcrossed 14 times onto C57BL/6; they then assessed using an ethologically based approach which resolves all topographies behaviour within mouse repertoire. The ethogram mice, on...
The R408W phenylketonuria mutation in Europe has arisen by recurrent the human phenylalanine hydroxylase (PAH) locus and is associated with two major PAH haplotypes. R408W-2.3 exhibits a west-to-east cline of relative frequency reaching its maximum Balto–Slavic region, while R408W-1.8 an east-to-west peaking Connacht, most westerly province Ireland. Spatial autocorrelation analysis demonstrated that cline, like R408W-1.8, consistent pattern likely to have been established dispersal. Genetic...
Studies of knockout and transgenic mice have demonstrated key roles for genes encoding components the renin angiotensin system in blood pressure regulation. However, whether polymorphisms these contribute to cause essential hypertension humans is still a matter debate.We performed an experiment with dense tagging single-nucleotide polymorphism coverage 4 proteins that control overall activity cascade, namely renin, angiotensinogen, angiotensin-converting enzyme, enzyme 2, 2 Irish...