A5003243219- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- ATP Synthase and ATPases Research
- Medical Imaging Techniques and Applications
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Neurological Complications and Syndromes
- Management of metastatic bone disease
- Brain Tumor Detection and Classification
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- DNA Repair Mechanisms
- MRI in cancer diagnosis
- Pituitary Gland Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Advanced Radiotherapy Techniques
University of Alberta
2014-2025
Henry Ford Health System
2022-2024
University of Rochester Medical Center
2020-2024
New York Academy of Sciences
2023
John Wiley & Sons (Germany)
2023
Hudson Institute
2023
Moss Landing Marine Laboratories
2023
Henry Ford Hospital
2001-2022
Indiana University School of Medicine
2022
Indiana University
2022
From the Departments of Neurology, Memorial Sloan-Kettering Cancer Center, and Cornell University Medical College, New York, York
Cerium oxide (CeO2) nanoparticles have been shown to protect cells in culture from lethal stress, but no protection vivo has reported. Cardiac-specific expression of monocyte chemoattractant protein (MCP)-1 mice causes ischemic cardiomyopathy associated with activation endoplasmic reticulum (ER) stress. The aim this study was assess the effects CeO2 on cardiac function and remodeling as well ER stress response murine model cardiomyopathy.MCP-1 transgenic (MCP mice) wild-type controls were...
To evaluate the efficacy and safety of a slow-release formulation cytarabine (DepoCyt; Chiron Corp, Emeryville, CA, Skye Pharma, Inc, San Diego, CA) that maintains cytotoxic concentrations (ara-C) in CSF most patients for more than 14 days.Twenty-eight with lymphoma positive cytology were randomized to receive DepoCyt 50 mg once every 2 weeks or free ara-C twice week 1 month. Patients whose converted negative who did not have neurologic progression received an additional 3 months...
For many years, the diagnosis and classification of gliomas have been based on histology. Although studies including large populations patients demonstrated prognostic value histologic phenotype, variability in outcomes within groups limited utility this system. Nonetheless, histology was only proven widely accessible tool available at time, thus it used for clinical trial entry criteria, therefore determined recommended treatment options. Research to identify molecular changes that underlie...
Radiosurgery can deliver a single, large radiation dose to localized tumor using stereotactic approach and hence, requires accurate precise delivery of the target. Of extracranial organ targets, spine is considered suitable site for radiosurgery, because there minimal or no breathing-related movement. The authors studied spinal radiosurgery in patients with metastases determine its accuracy precision.The program was based on an image-guided intensity-modulated, shaped-beam radiosurgical...
The clinical and pathologic findings in 42 autopsy proved cases of cerebral infarction from cancer-associated non-bacterial thrombotic endocarditis were reviewed. Carcinoma the lung was most common malignancy. Most patients had disseminated cancer, but six patients, condition stable or remission, localized cancer; two not known to have cancer until neurologic symptoms developed. Neurologic focal, suggesting stroke 18; diffuse, metabolic encephalopathy nine; mixed five. signs often only...
The purpose of this cross-sectional, descriptive study was to identify predictors distress for family caregivers persons with a primary malignant brain tumor (PMBT). effect the care recipient's functional, cognitive, and neuropsychiatric status on caregiver burden depressive symptoms examined through telephone interviews 95 caregivers. Care recipients' consistently affected caregivers' burden, assisting activities daily living related schedules health. cognitive need assistance instrumental...
<h3>BACKGROUND AND PURPOSE:</h3> Despite availability of advanced imaging, distinguishing radiation necrosis from recurrent brain tumors noninvasively is a big challenge in neuro-oncology. Our aim was to determine the feasibility radiomic (computer-extracted texture) features differentiating on routine MR imaging (gadolinium T1WI, T2WI, FLAIR). <h3>MATERIALS METHODS:</h3> A retrospective study tumor performed 9 months (or later) post-radiochemotherapy 2 institutions. Fifty-eight patient...
We report the effect of cranial irradiation on seizure frequency in five adults with unresected (biopsy-proven) cerebral hemisphere low-grade astrocytoma and medically intractable epilepsy. Seizures were refractory to standard antiepileptic drugs for 7 months 27 years. Treatment 5,400 cGy 6,120 focal radiation reduced by more than 90% three patients (one whom became seizure-free) 75% (but less 90%) one patient. One patient had no response. Brain CT or MRI showed a partial tumor response four...
Stroke in the cancer patient is often caused by disorders of coagulation that are induced cancer, metastatic to central nervous system, or vascular injury due therapy. Nonbacterial thrombotic endocarditis association with diffuse thrombosis cerebral vessels cause infarction. Venous occlusion most common leukemic patients, but can also result from growth solid tumor adjacent skull dura. Chemotherapy administration associated a small risk arterial venous thrombosis. Radiation administered neck...
Complete prevalence proportions illustrate the burden of disease in a population. This study estimates 2010 complete malignant primary brain tumors overall and by Central Brain Tumor Registry United States (CBTRUS) histology groups, compares tumor to other common cancers as determined Surveillance, Epidemiology, End Results Program (SEER) age at (2010): children (0-14 y), adolescent young adult (AYA) (15-39 (40+ y).Complete were estimated using novel regression method extended from...
DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal this multi-centre cohort study was to determine the safety and efficacy treatment neoplastic meningitis due breast cancer. 50 mg injected once every 2 weeks one month induction therapy; responding patients were treated with an additional 3 months consolidation therapy. All had metastatic cancer positive CSF cytology or neurologic findings characteristic meningitis. median number doses 3,...
This study is to demonstrate the feasibility of spinal radiosurgery using an image‐guided intensity‐modulated radiosurgical (IMRS) procedure. A dedicated Novalis® shaped beam surgery unit equipped with a built‐in micro‐multileaf collimator (mMLC) single 6 MV photon was used. Each patient simulated in supine position AcQsim CT simulator infrared sensitive markers for localization. variety different treatment plans were developed, but most common plan use seven coplanar beams minimize...
Object The aim of this study was to evaluate the effectiveness brachytherapy using GliaSite Radiation Therapy System in patients with a newly diagnosed resected single brain metastasis. primary end point local tumor control. secondary points included patient survival, distant recurrence, quality life, and treatment toxicity. Methods authors conducted prospective multiinstitutional phase II prescribed at 60-Gy dose administered 1-cm depth after resection No whole-brain radiation therapy...
Abstract Arsenic‐induced polyneuropathy is traditionally classified as an axonal‐loss type, electrodiagnostically resulting in low amplitude or absent sensory and motor responses, relatively preserved proximal distal conduction rates, denervation. We report four patients with a subacute onset progressive polyradiculoneuropathy following high‐dose arsenic poisoning. In three patients, early electrodiagnostic testing demonstrated findings suggestive of acquired segmental demyelinating...
The clinical and diagnostic findings in 13 patients with leptomeningeal metastasis from supratentorial malignant gliomas are reported. Criteria for inclusion this study were positive myelographic examination, cerebrospinal fluid cytology on two or more samples, evidence of seeding at autopsy. Eight had premortem symptoms metastasis, the diagnosis confirmed during life 5 patients. Average survival after onset was 3 months (range, 1 to months). Comparison autopsied group 10 concurrent without...
Abstract Purpose To assess if interval changes in metabolic status normal cerebral tissue after radiation therapy (RT) can be detected by 2D CSI (chemical shift imaging) proton spectroscopy. Materials and Methods Eleven patients with primary brain tumors undergoing cranial were included. 2D‐CSI MRS was performed before, during, the course of RT following parameters: TE/TR 144/1500 ms, field view (FOV) 24, thickness 10 mm, matrix 16 × 16. The ratios choline/creatine (Cho/Cr),...
To compare the utility of quantitative PET/MRI, dynamic susceptibility contrast (DSC) perfusion MRI (pMRI), and PET/CT in differentiating radiation necrosis (RN) from tumor recurrence (TR) patients with treated glioblastoma multiforme (GBM).The study included 24 GBM surgery, radiotherapy, temozolomide who presented progression on imaging follow-up. All underwent PET/MRI pMRI during a single examination. Additionally, 19 same day. Diagnosis was established by pathology 17 clinical/radiologic...