A5064201991- Adipose Tissue and Metabolism
- Clinical Nutrition and Gastroenterology
- Endoplasmic Reticulum Stress and Disease
- Genetics and Neurodevelopmental Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Neonatal Respiratory Health Research
- Heterotopic Ossification and Related Conditions
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Vitamin C and Antioxidants Research
- Fibroblast Growth Factor Research
- Electrolyte and hormonal disorders
KU Leuven
2019-2024
Article14 May 2020Open Access Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver Vanessa Dubois orcid.org/0000-0001-8894-2980 Inserm, CHU Lille, Institut Pasteur de U1011-EGID, University of France Search for more papers by this author Céline Gheeraert Wouter Vankrunkelsven orcid.org/0000-0003-0943-043X Clinical Division and Laboratory Intensive Care Medicine, Department Cellular Molecular KU Leuven, Belgium Julie Dubois-Chevalier Hélène Dehondt...
Abstract Background Muscle weakness is a frequently occurring complication of sepsis, associated with increased morbidity and mortality. Interestingly, obesity attenuates sepsis‐induced muscle wasting weakness. As the adipokine leptin strongly elevated in has been shown to affect homeostasis non‐septic conditions, we aimed investigate whether mediates protective effect on Methods In mouse model investigated effects genetic inactivation obese mice (leptin‐deficient vs. diet‐induced mice)...
Despite the presumed importance of preventing and treating micronutrient mineral deficiencies, it is still not clear how to optimize measurement administration in critically ill patients. In order design future comparative trials aimed at optimizing management, an important first step gain insight current practice micronutrient, phosphate magnesium monitoring administration.Within metabolism-endocrinology-nutrition (MEN) section European Society Intensive Care Medicine (ESICM), working group...
Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during critical illness. FGF21 a pleiotropic hormone that mediates adaptive responses tissue injury repair in various chronic pathological conditions. Animal studies have suggested the illness-induced may certain extent protect against acute lung, liver, kidney brain injury. However, also mediate fasting-induced loss of muscle mass force. Such force frequent problem...
Abstract Disclosure: C. Lauwers: None. M.P. Casaer: W. Vankrunkelsven: S. Derde: I. Derese: Vander Perre: P. Vermeersch: G.H. Van Den Berghe: L. Langouche: Introduction: In septic mice, infusion of ketone bodies (beta-hydroxybutyrate (BHB)) attenuated muscle weakness, a debilitating complication critical illness. Interestingly, in critically ill children, fasting-induced ketosis also improved outcomes, but adults upon fasting was impaired, likely due to suppression PPARα, key transcriptional...
Background: Critically ill patients often develop multiple organ failure accompanied by profound metabolic and endocrine alterations. The pathogenesis is incompletely understood, but the development of cellular stress, including endoplasmic reticulum (ER) might play a pivotal role (1). Indeed, markers ER stress have been observed in critical illness, both animal models human patients, correlating with dysfunction normally activates unfolded protein response (UPR). UPR follows distinct...