A5072302588- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Global Maternal and Child Health
- Diagnosis and treatment of tuberculosis
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- HIV/AIDS Research and Interventions
- Lymphoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV/AIDS Impact and Responses
- HIV Research and Treatment
- Malaria Research and Control
- Viral Infections and Vectors
- Eosinophilic Esophagitis
- Surgical site infection prevention
- Antibiotic Use and Resistance
- Neonatal Respiratory Health Research
- Hepatitis C virus research
- Viral Infections and Outbreaks Research
- HIV-related health complications and treatments
- Surgical Sutures and Adhesives
- HIV/AIDS drug development and treatment
- Hepatitis Viruses Studies and Epidemiology
- Global Public Health Policies and Epidemiology
University of Rwanda
2018-2025
Institute of Medical Microbiology and Hygiene
2025
Heinrich Heine University Düsseldorf
2020-2024
Düsseldorf University Hospital
2020-2024
University of Global Health Equity
2013
Surgical Site Infections (SSI) are the most reported health acquired infection and common surgical complication in both developed developing countries. In countries such as Rwanda, there is a paucity of published reports on pattern SSI, therefore this study aimed at assessing incidence, risk factors antibiotic profile pathogens responsible SSI.This prospective included 294 patients admitted between October 10, 2017 February 12, 2018 to department University Teaching Hospital Kigali. Patients...
Background Rwanda reported significant reductions in malaria burden following scale up of control intervention from 2005 to 2010. This study sought to; measure prevalence, describe spatial clustering and investigate for risk factors among health-centre-presumed cases their household members Eastern Rwanda. Methods A two-stage health centre household-based survey was conducted Ruhuha sector, April October 2011. At the centre, data, including diagnosis individual level factors, collected....
Antimicrobial resistance (AMR) is an imminent threat to modern medicine. As the efficacy of treatment regimens reduced, mortality and morbidity attributed infectious diseases expected rise dramatically across globe. stewardship good prescription practices are critical conserving available therapeutics; it appropriate, therefore, appraise our attitudes knowledge antimicrobial resistance, particularly for future healthcare practitioners.This a descriptive cross-sectional study that was...
CD19 and CXCR4 are pivotal regulators of B-cell activation migration, respectively. Specifically, signaling critically influences the dissemination various malignant B cells through constitutive aberrant expression. This study explores interaction between in context lymphomas, particularly focusing on diffuse large lymphoma (DLBCL) Waldenström Macroglobulinemia (WM). We assessed roles survival CXCL12-induced migration by using knockout (KO) DLBCL WM origin alongside evaluating impact...
We evaluated post-vaccination immunity status and describe potential risk factors associated with the lack of response among healthcare workers (HCWs) at a tertiary care hospital in Kigali, Rwanda. Of 373 HCWs, 291 (78.2%) were female 81 (21.8%) male. The mean age study participants was 40.2 years (standard deviation [SD], 7.7 years), within range 24–41 years. Participants' BMI 25.4 ± 6.6 kg/m2, more than half patients (60.3%) being overweight. 96% received all three doses vaccination. A...
Altered monocyte differentiation and effector functions characterize immune pathogenesis of tuberculosis. IL-7 is an important factor for proliferation T cells impaired sensitivity due to decreased receptor α-chain (IL-7Rα) expression was found in patients with acute Peripheral blood monocytes have moderate IL-7Rα increased levels were described inflammatory diseases. In this study, we investigated a potential role We analyzed the phenotype from tuberculosis (n = 33), asymptomatic contacts...
Abstract Monocyte‐derived macrophages contribute centrally to immune protection in Mycobacterium tuberculosis infection and changes monocyte phenotype characterize immunopathology patients. Recent studies highlighted an important role of the plasma milieu immunopathology. Here, we investigated pathology patients with acute determined effects on as well cytokine signalling reference monocytes. Patients ( n = 37) asymptomatic contacts (controls 35) were recruited part a hospital‐based study...
Bacterial components and cytokines induce IL-7 receptor (IL-7Rα) expression in monocytes. Aberrant low IL-7Rα of monocytes has been identified as a feature tuberculosis immunopathology. Here, we investigated the mechanisms underlying regulation serum effects on expression. Serum samples from patients healthy controls, cytokine candidates, mycobacterial were analyzed for vitro primary monocytes, monocyte-derived macrophages (MDM), monocyte cell lines. during culture role FoxO1 characterized....
Abstract Objective To determine prevalent MDR ‐ TB genotypes and describe treatment outcome bacteriology conversion in patients. Methods Review of laboratory records 173 patients from all over Rwanda who initiated under programmatic management ( PMDT ) between 2014 2015. Fifty available archived isolates were genotyped by mycobacterial interspersed repetitive units – variable number tandem repeats MIRU VNTR genotyping. Result Of the 170 whose was known, 114 (66.3%) cured 36 (21%) completed...
CD19 and CXCR4 are pivotal regulators of B cell activation migration, respectively. Specifically, signaling critically influences the dissemination various malignant cells through constitutive aberrant expression. This study explores interaction between in context B-cell lymphomas, particularly focusing on diffuse large lymphoma (DLBCL) Waldenström Macroglobulinemia (WM). We assessed roles survival CXCL12-induced migration by using knock-out (KO) DLBCL WM origin, alongside evaluating impact...
Background: In response to the need for interventions that facilitate accessibility of medical services in poor communities, an outreach activity was organized semi-rural areas Maraba and Simbi sectors located Huye district, Southern province Rwanda. The undertaken by health sciences students involved screening hypertension, risk diabetes, hepatitis, anemia, eye disease, HIV.Methods: Clinical assessments rapid laboratory diagnostic assays were used screen invited residents from two selected...
Cystic fibrosis (CF) is a genetic disorder caused by mutations of CFTR gene which affects epithelial cell functions in different organs. It manifests primarily the lung and leads to severe symptoms. The reduced ciliated-clearance high viscous mucus chronic infections turns alters immune responses. Innate lymphoid cells (ILCs) are crucial response against pathogens tissue homeostasis their importance has been demonstrated disease such as COPD, but studies ILCs CF scarce. In present study...
Background: Altered monocyte differentiation and effector functions characterize tuberculosis pathogenesis. Interleukin-7 (IL-7) mediated T-cell are impaired in acute patients IL-7 effects on monocytes hardly defined. Here we investigated receptor (IL-7Ra) expression of from charcterized the anti-mycobacterial immune response.Methods: We analyzed phenotype distribution peripheral blood subpopulations (n=33), latently Mycobacterium (M.) infected contacts (LTBI; n=30) healthy controls (n=20)...