A5050768459- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Genetic Neurodegenerative Diseases
- Immune cells in cancer
- Chemokine receptors and signaling
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Lichen and fungal ecology
- Galectins and Cancer Biology
- Barrier Structure and Function Studies
- HER2/EGFR in Cancer Research
- Hematopoietic Stem Cell Transplantation
- NF-κB Signaling Pathways
- Adenosine and Purinergic Signaling
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Plant Pathogens and Fungal Diseases
- Nuclear Receptors and Signaling
University Medical Center
2025
Universität Ulm
2018-2025
University Hospital Ulm
2019-2024
University of Freiburg
2013-2021
Saha Institute of Nuclear Physics
2009-2016
Significance CLL is characterized by autonomous B cell receptor (BCR) signaling. subsets are empirically defined sequence similarities of the BCR heavy chain. However, in unfavorable subset 2, an acquired mutation (termed R110) light chain stimulates This study demonstrates that oncogenic R110 dictates prognosis and not restricted to conventional 2. Interestingly, carriers a particular light-chain allele ( IGLV3-21 * 01 ) predisposed develop because this enables signaling as single-point...
Article23 April 2019Open Access Transparent process Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR Corinna S Setz Institute Immunology, Ulm University Medical Center, Ulm, Germany Search for more papers this author Ahmad Khadour Valerio Renna orcid.org/0000-0001-6954-2113 Joseena Iype Department Molecular Biology III, Faculty Biology, Albert-Ludwigs Freiburg, Eva Gentner Xiaocui He Moumita Datta Marc Young Lars Nitschke Division...
GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in gastrointestinal mucosa and inflamed skin. Emerging evidence suggests its involvement inflammatory disorders cancers. This study investigates effects of GPR15LG on signaling downstream functions C-X-C chemokine type 4 (CXCR4), which plays critical role immune cell trafficking cancer metastasis. The results demonstrate that binds to orthosteric site CXCR4, modulating context-dependent...
CD19 and CXCR4 are pivotal regulators of B-cell activation migration, respectively. Specifically, signaling critically influences the dissemination various malignant B cells through constitutive aberrant expression. This study explores interaction between in context lymphomas, particularly focusing on diffuse large lymphoma (DLBCL) Waldenström Macroglobulinemia (WM). We assessed roles survival CXCL12-induced migration by using knockout (KO) DLBCL WM origin alongside evaluating impact...
Abstract The random gene segment rearrangement during B cell development ensures Ab repertoire diversity. Because this process might generate autoreactive specificities, it has been proposed that stringent selection mechanisms prevent the of cells. However, conventional assays to identify cells usually employ in vitro–generated Abs, which differ from membrane-bound BCRs. In study, we used a cell-based assay investigate autoreactivity BCRs derived different developmental stages human...
Several studies suggest that women have a higher risk to develop Alzheimer's disease (AD) than men. In particular, the number of pregnancies was shown be factor for AD and with several on average had an earlier onset disease, thus making childbearing factor. However, impact being pregnant Aβ plaque pathology adult neurogenesis still remains elusive. Postmortem analysis revealed 5xFAD transgenic mice significantly more plaques in hippocampus from G10 onwards Ki67 DCX positive cells...
Dysregulation of the CXCL12/CXCR4 axis is implicated in autoimmune, inflammatory, and oncogenic diseases, positioning CXCR4 as a pivotal therapeutic target. We evaluated optimized variants specific endogenous antagonist, EPI-X4, addressing existing challenges stability potency. Our structure-activity relationship study investigates conjugation EPI-X4 derivatives with long-chain fatty acids, enhancing serum albumin interaction receptor affinity. Molecular dynamic simulations revealed that...
In chronic lymphocytic leukemia (CLL), survival of neoplastic cells depends on microenvironmental signals at lymphoid sites where the crosstalk between integrin VLA-4 (CD49d/CD29), expressed in ~40% CLL, and B-cell receptor (BCR) occurs. Here, BCR engagement inside–out activates VLA-4, thus enhancing VLA-4-mediated adhesion CLL cells, which turn obtain pro-survival from surrounding microenvironment. We report that is also able to effectively activate circulating CD49d-expressing through an...
Abstract Background HIP1 Protein Interactor (HIPPI) is a pro-apoptotic protein that induces Caspase8 mediated apoptosis in cell. We have shown earlier HIPPI could interact with specific 9 bp sequence motif, defined as the binding site (HBS), present upstream promoter of Caspase1 gene and regulate its expression. also HIPPI, without any known nuclear localization signal, be transported to nucleus by HIP1, NLS containing nucleo-cytoplasmic shuttling protein. Thus our work aims at investigation...
Earlier we have shown that exogenous expression of HIPPI, a molecular partner Huntingtin interacting protein HIP-1, induces apoptosis and increases caspases-1, −8 −10 in HeLa Neuro2A cells. The C-terminal pseudo death effector domain HIPPI (pDED-HIPPI) specifically interacts with the putative promoter sequences these genes. In present manuscript, predict from structural modeling pDED-HIPPI R393 is important for such interaction. R393E mutation decreases interaction caspase-1 Expression...
Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph
A considerable proportion of peripheral B cells is autoreactive, and it unclear how the activation such potentially harmful regulated. In this study, we show that different thresholds or IgM IgD BCRs adjust cell to diverse requirements during development. We rely on autoreactive 3-83 model BCR generate analyze mice expressing exclusively two backgrounds determine stages autoreactivity, depending presence absence cognate Ag. By comparing these models with IgM-expressing control mice, found...
The generation, differentiation, survival and activation of B cells are coordinated by signals emerging from the cell antigen receptor (BCR) or its precursor, pre-BCR. adaptor protein SLP65 (also known as BLNK) is an important signaling factor that controls pre-B differentiation down-regulation PI3K signaling. Here, we investigated mechanism which interferes with We found induces activity small GTPase RHOA, activates PTEN, a negative regulator signaling, enabling translocation to plasma...
CD19 and CXCR4 are pivotal regulators of B cell activation migration, respectively. Specifically, signaling critically influences the dissemination various malignant cells through constitutive aberrant expression. This study explores interaction between in context B-cell lymphomas, particularly focusing on diffuse large lymphoma (DLBCL) Waldenström Macroglobulinemia (WM). We assessed roles survival CXCL12-induced migration by using knock-out (KO) DLBCL WM origin, alongside evaluating impact...
Germinal center (GC) reaction is crucial for the generation of high-affinity antibodies against any infection. To address role specific gene in GC, knock out mouse models are generally used. However, since GC multicellular event, complete cannot pin point cell intrinsic effect certain genes reaction. Here, we describe a detail protocol analysis competitive bone marrow chimeric mice generated by transplanting 1:1 mixture CD45.1 and CD45.2 positive donor (BM) cells immunodeficient Rag2-/-gc-/-...