A5058018749- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Sports Performance and Training
- RNA Research and Splicing
- Nuclear Receptors and Signaling
- RNA modifications and cancer
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- RNA regulation and disease
- Children's Physical and Motor Development
- Neurogenesis and neuroplasticity mechanisms
- Sport Psychology and Performance
- Cancer-related molecular mechanisms research
- Heart Failure Treatment and Management
- Single-cell and spatial transcriptomics
- Muscle Physiology and Disorders
- Tissue Engineering and Regenerative Medicine
- COVID-19 Clinical Research Studies
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Mental Health Treatment and Access
- vaccines and immunoinformatics approaches
- Alcoholism and Thiamine Deficiency
- Synthesis of β-Lactam Compounds
Daffodil International University
2025
German Center for Neurodegenerative Diseases
2018-2024
St. Francis Hospital
2024
Shaheed Suhrawardy Medical College
2022
Dhaka Medical College and Hospital
2020
University of Dhaka
2012-2018
Women Medical College
2012-2015
University of Göttingen
2013
Islamic University of Technology
2012
Institute of Psychiatry and Neurology
1993
ABSTRACT Aims Deregulation of epigenetic processes and aberrant gene expression are important mechanisms in heart failure. Here we studied the potential relevance m6A RNA methylation failure development. Methods results We analysed via next‐generation sequencing. found that approximately one quarter transcripts healthy mouse human exhibit methylation. During progression to observed changes exceed both human. RNAs with altered were mainly linked metabolic regulatory pathways, while level...
Abstract Background Human pluripotent stem cell‐derived muscle models show great potential for translational research. Here, we describe developmentally inspired methods the derivation of skeletal cells and their utility in tissue engineering with aim to model regeneration dystrophy vitro. Methods Key steps include directed differentiation human embryonic progenitors followed by primary secondary foetal myogenesis into three‐dimensional muscle. To simulate Duchenne muscular (DMD), a...
Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, vital brain region responsible learning and memory. Previous research demonstrated that exercise-mediated improvement of memory humans rodents correlates with increased adult neurogenesis processes related enhanced synaptic plasticity. Nevertheless, underlying molecular mechanisms are not fully understood. With aim further elucidate these mechanisms, we provide comprehensive...
Acetylcholine-esterase (AchE) inhibitors are one of the most potent drug molecules against Alzheimer's disease (AD).But, patients treated with current AchE often experience severe side effects.Quercetin is a plant flavonoid compound which can act as inhibitor and it may be better alternative to in terms effectiveness no or fewer effects.Aims: The aim study was compare quercetin conventional search for candidate.Methods materials: Physico-chemical properties drugs were predicted using...
Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise is observed in synucleinopathies parallel to aSyn aggregation and accompanied transcript deregulation. Objective: We sought identify microRNAs associated with synaptic processes that may contribute dysfunction degeneration synucleinopathies. Methods: performed small RNA-sequencing midbrain from 6-month-old transgenic mice expressing A30P mutant aSyn, followed...
Abstract Neurons are highly compartmentalized cells that depend on local protein synthesis. Messenger RNAs (mRNAs) have thus been detected in neuronal dendrites, and more recently the pre- postsynaptic compartments as well. Other RNA species such microRNAs also described at synapses where they believed to control mRNA availability for translation. A combined dataset analyzing synaptic coding non-coding RNAome via next-generation sequencing approaches is, however, still lacking. Here, we...
Article20 January 2021Open Access Transparent process Epigenetic gene expression links heart failure to memory impairment Md Rezaul Islam Department for Systems Medicine and Epigenetics, German Center Neurodegenerative Diseases (DZNE), Göttingen, Germany Search more papers by this author Dawid Lbik Clinic of Cardiology Pneumology, Georg-August-University, GermanyThese authors contributed equally work M Sadman Sakib workCorrection added on 05 March 2021, after first online publication: the...
MicroRNAs have been linked to synaptic plasticity and memory function are emerging as potential biomarkers therapeutic targets for cognitive diseases. Most of these data stem from the analysis model systems or postmortem tissue patients which mainly represents an advanced stage pathology. Due in-accessibility human brain upon experimental manipulation, it is still challenging identify microRNAs relevant cognition, however a key step future translational studies. Here, we employ exercise...
Aim: Chikungunya virus, an arthropod-borne alphavirus, belongs to the Togavirus family. Despite severe epidemic outbreaks on several occasions, not much progress has been made with regard epitope-based drug design for chikungunya virus. In this study we performed a proteome-wide search look conserved region among available viral proteins, one which capacity trigger significant immune response. Materials & methods: The was analyzed by performing alignment of sequences collected from sources...
Sleep is a conserved behavioral state. Invertebrates typically show quiet sleep, whereas in mammals, sleep consists of periods nonrapid-eye-movement (NREMS) and REM (REMS). We previously found that the transcription factor AP-2 promotes
Article22 November 2021Open Access Source DataTransparent process Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and regulation neuron-enriched genes Alexandra Michurina Department Systems Medicine Epigenetics, German Center Neurodegenerative Diseases (DZNE), Göttingen, Germany These authors contributed equally to this work Search more papers by author M Sadman Sakib Cemil Kerimoglu Corresponding Author [email protected] orcid.org/0000-0001-6523-5925...
Increased COVID-19 vaccine hesitancy presents a major hurdle in global efforts to contain the pandemic. This study was designed estimate prevalence of adverse events after first dose Covishield (AstraZeneca) among physicians Bangladesh. A cross-sectional conducted using an online questionnaire for (n = 916) Physicians who received at least one were included. The carried out from April 12 May 31, 2021. More than 58% respondents 533) reported or more events. Soreness injected arm (71.9%),...
The recent outbreak of Coronavirus Disease 2019 (COVID-19) is a major threat to human health and the global economy. In addition development vaccines there an urgent need for preventive therapeutic strategies towards severe COVID-19. Key this would be better understanding molecular mechanismsoiuuuu affected by SARS-COV-2. To address this, we performed systems biology approach integrating available RNA-seq datasets from post-mortem lung tissue COVID-19 patients cell culture models infected...
Postoperative shivering is one of the recognized complications following general, regional anaesthesia and also effect some surgical procedure specially in recovery room. Shivering increases muscular activity, O2 consumption, CO2 production may result hypoxaemia, hypercarbia lactic acidosis. It not only uncomfortable but cold sensation which even worse feeling than pain sensation. As a preventing symptoms clearly desirable beneficial for patient. Different methods are suggested prevention...
Background : The term “Intra-cranial space occupying lesion” (ICSOL) is defined as any neoplasm, benign or malignant, primary secondary, well inflammatory parasitic mass lying within the cranial cavity. Advances in intracranial imaging have made detection of lesions relatively accurate and enabling us to focus on etiology these space-occupying lesions. Many reports suggested that both incidence pattern are subject considerable geographic racial variations. Knowledge regional peculiarities...
Background and study aim: Torticollis is the postural deformity of head neck. Congenital Muscular (CMT) a neck detected at birth or shortly after birth, primarily resulting from unilateral shortening Sternocleidomastoid muscle (SCM). In neonates infants, patient may be cured conservatively by physiotherapy but surgery treatment choice for children adolescents. There are various techniques surgery. Division both sternal clavicular SCM very easy method which was practiced in this study. Here...
Abstract Neurons are highly compartmentalized cells that depend on local protein synthesis. Thus, messenger RNAs (mRNAs) have been detected in neuronal dendrites and more recently also at the pre- postsynaptic compartment. Other RNA species, such as microRNAs, described synapses where they believed to control mRNA availability for translation. Nevertheless, a combined dataset analyzing synaptic coding non-coding RNAome via next-generation sequencing approaches is missing. Here we isolate...