A5058348150- RNA modifications and cancer
- interferon and immune responses
- Retinal Development and Disorders
- Cancer Research and Treatments
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Retinal Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Immune cells in cancer
- RNA and protein synthesis mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and biosynthesis
- Cancer Diagnosis and Treatment
- Medication Adherence and Compliance
- Sphingolipid Metabolism and Signaling
- Microtubule and mitosis dynamics
- Thermal Regulation in Medicine
- Protein Degradation and Inhibitors
- Neuroscience and Neural Engineering
- Adenosine and Purinergic Signaling
- Retinoids in leukemia and cellular processes
- Actinomycetales infections and treatment
- Histone Deacetylase Inhibitors Research
- Metabolomics and Mass Spectrometry Studies
University of Southern California
2020-2024
Amgen (United States)
2021
LAC+USC Medical Center
2020
Georgia Institute of Technology
2017
University of Pennsylvania
2016
John Radcliffe Hospital
2012
All India Institute of Medical Sciences
1994
At Bristol
1981
Retinitis pigmentosa (RP) is a retinal degenerative disease associated with diversity of genetic mutations. In natural progression study (NPS) evaluating the molecular changes in Royal College Surgeons (RCS) rats using lipidomic profiling, RNA sequencing, and gene expression analyses, degeneration from p21 to p60 were evaluated, where reductions ALOX15 corresponded progression. This important enzyme catalyzes formation specialized pro-resolving mediators (SPMs) such as lipoxins (LXs),...
Retinal degenerative diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa, lack effective therapies. Conventional monotherapeutic approaches fail to target the multiple affected pathways in retinal degeneration. However, pigment epithelium (RPE) secretes several neurotrophic factors addressing diverse cellular pathways, potentially preserving photoreceptors. This study explored human embryonic stem cell-derived, polarized RPE soluble (PRPE-SF) as a combination...
Resolving tumor-associated inflammation in the tumor microenvironment (TME) may promote antitumor effects. Lipoxin A4 (LXA4) is a short-lived endogenous bioactive lipid with potent anti-inflammatory and pro-resolving properties. Here, biomimetic of LXA4, NAP1051, was shown to have LXA4-like vitro properties activity colorectal cancer xenograft models. NAP1051 inhibited neutrophil chemotaxis toward fMLP dose-dependently promoted dTHP-1 efferocytosis which equipotent aspirin-triggered lipoxin...
Retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, significantly contribute to adult blindness. The Royal College of Surgeons (RCS) rat is a well-established disease model for studying these dystrophies; however, molecular investigations remain limited. We conducted comprehensive analysis retinal in RCS rats, an immunodeficient (iRCS) sub-strain, using ocular coherence tomography, electroretinography, histology, dissection transcriptomics...
Previous reports of hypothyroidism in association with short
Abstract Background: Cancer survival is dependent on the increase of protein synthesis for cell migration, proliferation and metastasis. adaptive mechanisms include upregulation endoplasmic reticulum (ER) activities to accommodate increases in misfolded proteins. Sarcoendoplasmic calcium ATPase (SERCA) are important regulators found reticulum, where inhibition can lead misfolding. Since breast cancer cells express higher level SERCA2, its overexpression maybe a target drug development....
Abstract Background: Post-menopausal breast cancer survivors are often prescribed aromatase inhibitors (AIs) to decrease the chance of recurrence. Despite their efficacy, many do not fully adhere AI regimen. To improve adherence rates, it is important understand which patient factors associated with adherence. Current research has mostly focused on demographic, cancer, and symptom variables, most cannot be modified. One relevant factor that may modifiable health beliefs, include perceived...
<p>Figure S2 shows the direct cytotoxicity of NAP1051 and relative tumor volume HCT116 model.</p>
<p>Figure S3 shows the gating strategy for analysis of immune cell subpopulations in spleen and tumor.</p>
<p>Figure S1 shows the gating strategy for PMN apoptosis analysis, RT-PCR, immunofluorescence staining, and flow cytometry analyses of FPR2/ALX-transfected HEK cells, effect NAP1051 on dTHP-1 cells with selective kinase inhibitors, Western blot normal cells</p>
<p>Figure S4 shows the gating strategy for analysis of myeloid cell subpopulations in spleen or tumor.</p>
<p>Figure S5 shows secondary antibody controls for immunofluorescence staining and representative images of the CitH3 PAD4/Ly6G staining.</p>
<p>Figure S1 shows the gating strategy for PMN apoptosis analysis, RT-PCR, immunofluorescence staining, and flow cytometry analyses of FPR2/ALX-transfected HEK cells, effect NAP1051 on dTHP-1 cells with selective kinase inhibitors, Western blot normal cells</p>
<p>Figure S3 shows the gating strategy for analysis of immune cell subpopulations in spleen and tumor.</p>
<p>Figure S2 shows the direct cytotoxicity of NAP1051 and relative tumor volume HCT116 model.</p>