A5086603696- RNA modifications and cancer
- interferon and immune responses
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- ATP Synthase and ATPases Research
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and biosynthesis
- Immune cells in cancer
- RNA and protein synthesis mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Lipids, and Metabolism
- COVID-19 Clinical Research Studies
- Trace Elements in Health
- Retinal Diseases and Treatments
- Retinoids in leukemia and cellular processes
- Enzyme function and inhibition
- Inflammatory mediators and NSAID effects
- Neonatal Health and Biochemistry
- Thermal Regulation in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Long-Term Effects of COVID-19
- Folate and B Vitamins Research
University of Southern California
2018-2024
LAC+USC Medical Center
2020
Retinitis pigmentosa (RP) is a retinal degenerative disease associated with diversity of genetic mutations. In natural progression study (NPS) evaluating the molecular changes in Royal College Surgeons (RCS) rats using lipidomic profiling, RNA sequencing, and gene expression analyses, degeneration from p21 to p60 were evaluated, where reductions ALOX15 corresponded progression. This important enzyme catalyzes formation specialized pro-resolving mediators (SPMs) such as lipoxins (LXs),...
Resolving tumor-associated inflammation in the tumor microenvironment (TME) may promote antitumor effects. Lipoxin A4 (LXA4) is a short-lived endogenous bioactive lipid with potent anti-inflammatory and pro-resolving properties. Here, biomimetic of LXA4, NAP1051, was shown to have LXA4-like vitro properties activity colorectal cancer xenograft models. NAP1051 inhibited neutrophil chemotaxis toward fMLP dose-dependently promoted dTHP-1 efferocytosis which equipotent aspirin-triggered lipoxin...
Retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, significantly contribute to adult blindness. The Royal College of Surgeons (RCS) rat is a well-established disease model for studying these dystrophies; however, molecular investigations remain limited. We conducted comprehensive analysis retinal in RCS rats, an immunodeficient (iRCS) sub-strain, using ocular coherence tomography, electroretinography, histology, dissection transcriptomics...
Traumatic brain injury (TBI) is a common and prevalent condition that affects large numbers of people across range ages. Individuals engaging in physical activities victims accidents are at higher risk for TBI. There lack available treatment specifically Given the difficulty to determine its precise location brain, TBI remains difficult fully diagnose or treat. Herein, we disclose novel strategy directing therapeutic agents sites, without need activity brain. This approach based on use...
More than 2.8 million annually in the United States are afflicted with some form of traumatic brain injury (TBI), where 75% victims have a mild TBI (MTBI). risk is higher for individuals engaging physical activities or involved accidents. Although MTBI may not be initially life-threatening, large number these can develop cognitive and dysfunctions. These late clinical sequelae been attributed to development secondary injuries that occur minutes days after initial impact. To minimize damage...
Using metabolomics data from colorectal cancer cases and controls, we found contrasting trends in their plasma folate metabolites.
Abstract Background: Cancer survival is dependent on the increase of protein synthesis for cell migration, proliferation and metastasis. adaptive mechanisms include upregulation endoplasmic reticulum (ER) activities to accommodate increases in misfolded proteins. Sarcoendoplasmic calcium ATPase (SERCA) are important regulators found reticulum, where inhibition can lead misfolding. Since breast cancer cells express higher level SERCA2, its overexpression maybe a target drug development....
Abstract Glucose regulated protein 78 kDa (GRP78), also referred to as immunoglobulin heavy chain binding (BiP), is a chaperone belonging HSP70 family. GRP78 resides primarily in the lumen of endoplasmic reticulum (ER) and plays an important role folding, by targeting misfolded proteins, controlling activation transmembrane ER stress sensor Ca2+ homeostasis. It contains KDEL sequence (Lys-Asp-Glu-Leu) on its C-terminus, which responsible for retention through onto receptor. Some proteins...
<p>Figure S2 shows the direct cytotoxicity of NAP1051 and relative tumor volume HCT116 model.</p>
<p>Figure S3 shows the gating strategy for analysis of immune cell subpopulations in spleen and tumor.</p>
<p>Figure S1 shows the gating strategy for PMN apoptosis analysis, RT-PCR, immunofluorescence staining, and flow cytometry analyses of FPR2/ALX-transfected HEK cells, effect NAP1051 on dTHP-1 cells with selective kinase inhibitors, Western blot normal cells</p>
<p>Figure S4 shows the gating strategy for analysis of myeloid cell subpopulations in spleen or tumor.</p>
<p>Figure S5 shows secondary antibody controls for immunofluorescence staining and representative images of the CitH3 PAD4/Ly6G staining.</p>
<p>Figure S1 shows the gating strategy for PMN apoptosis analysis, RT-PCR, immunofluorescence staining, and flow cytometry analyses of FPR2/ALX-transfected HEK cells, effect NAP1051 on dTHP-1 cells with selective kinase inhibitors, Western blot normal cells</p>
<p>Figure S3 shows the gating strategy for analysis of immune cell subpopulations in spleen and tumor.</p>
<p>Figure S2 shows the direct cytotoxicity of NAP1051 and relative tumor volume HCT116 model.</p>
<p>Figure S5 shows secondary antibody controls for immunofluorescence staining and representative images of the CitH3 PAD4/Ly6G staining.</p>
<p>Figure S4 shows the gating strategy for analysis of myeloid cell subpopulations in spleen or tumor.</p>
<div>Abstract<p>Resolving tumor-associated inflammation in the tumor microenvironment (TME) may promote antitumor effects. Lipoxin A4 (LXA4) is a short-lived endogenous bioactive lipid with potent anti-inflammatory and pro-resolving properties. Here, biomimetic of LXA4, NAP1051, was shown to have LXA4-like <i>in vitro</i> properties activity colorectal cancer xenograft models. NAP1051 inhibited neutrophil chemotaxis toward fMLP dose-dependently promoted dTHP-1...
<div>Abstract<p>Resolving tumor-associated inflammation in the tumor microenvironment (TME) may promote antitumor effects. Lipoxin A4 (LXA4) is a short-lived endogenous bioactive lipid with potent anti-inflammatory and pro-resolving properties. Here, biomimetic of LXA4, NAP1051, was shown to have LXA4-like <i>in vitro</i> properties activity colorectal cancer xenograft models. NAP1051 inhibited neutrophil chemotaxis toward fMLP dose-dependently promoted dTHP-1...