A5062299973- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Biopolymer Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Neonatal Health and Biochemistry
- Advanced biosensing and bioanalysis techniques
- Photoreceptor and optogenetics research
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmaceutical and Antibiotic Environmental Impacts
Washington University in St. Louis
2023
University of Southern California
2020
United States Military Academy
2014
Tetracyclines (TCs) are an important class of antibiotics threatened by emerging new resistance mechanism─enzymatic inactivation. These TC-inactivating enzymes, also known as tetracycline destructases (TDases), inactivate all TC antibiotics, including drugs last resort. Combination therapies consisting a TDase inhibitor and antibiotic represent attractive strategy for overcoming this type resistance. Here, we report the structure-based design, synthesis, evaluation bifunctional inhibitors...
Traumatic brain injury (TBI) is a common and prevalent condition that affects large numbers of people across range ages. Individuals engaging in physical activities victims accidents are at higher risk for TBI. There lack available treatment specifically Given the difficulty to determine its precise location brain, TBI remains difficult fully diagnose or treat. Herein, we disclose novel strategy directing therapeutic agents sites, without need activity brain. This approach based on use...
More than 2.8 million annually in the United States are afflicted with some form of traumatic brain injury (TBI), where 75% victims have a mild TBI (MTBI). risk is higher for individuals engaging physical activities or involved accidents. Although MTBI may not be initially life-threatening, large number these can develop cognitive and dysfunctions. These late clinical sequelae been attributed to development secondary injuries that occur minutes days after initial impact. To minimize damage...
ABSTRACT l ‐Ornithine‐based poly(peptides) have been widely utilized in the field of drug delivery, however few studies conducted examining details polymerization. In this article, effects monomer concentration, polymerization kinetics, polymer molecular weight and purity were investigated using ‐carboxybenzyl (Cbz)‐ornithine as a model monomer. The mechanism herein follows normal amine to produce having controlled weights, known chain ends narrow polydispersity index (PDI). A preferred...