A5002415173- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Reconstructive Surgery and Microvascular Techniques
- BRCA gene mutations in cancer
- Genetics and Neurodevelopmental Disorders
- Pharmaceutical industry and healthcare
- Advances in Oncology and Radiotherapy
- Cancer Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Cardiac Structural Anomalies and Repair
- Global Cancer Incidence and Screening
- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Academic Publishing and Open Access
- Trauma and Emergency Care Studies
- Pregnancy and preeclampsia studies
- Coronary Artery Anomalies
- Lung Cancer Research Studies
- Male Breast Health Studies
- Mechanical Circulatory Support Devices
- Ion channel regulation and function
- Patient Satisfaction in Healthcare
- Lung Cancer Treatments and Mutations
- Cardiac Valve Diseases and Treatments
Tufts Medical Center
2021-2024
Emory University
2014-2024
Osiris Therapeutics (United States)
2024
Stryker (United States)
2024
Tufts University
2019-2021
Brigham and Women's Hospital
2019
Harvard University
2019
University of Toledo
2016
Objective Early-onset epileptic encephalopathies have been associated with de novo mutations of numerous ion channel genes. We employed techniques modern translational medicine to identify a disease-causing mutation, analyze its altered behavior, and screen for therapeutic compounds treat the proband. Methods Three tools were utilized: (1) high-throughput sequencing technology novel mutation; (2) in vitro expression electrophysiology assays confirm variant protein's dysfunction; (3)...
Abstract N-methyl- d -aspartate receptors (NMDARs) are members of the glutamate receptor family and participate in excitatory postsynaptic transmission throughout central nervous system. Genetic variants GRIN genes encoding NMDAR subunits associated with a spectrum neurological disorders. The M3 transmembrane helices couple directly to agonist-binding domains form helical bundle crossing closed that occludes pore. functions as transduction element whose conformational change couples ligand...
Background: We aim to discern the impact of closed incision negative pressure therapy (ciNPT) on wound healing in oncoplastic breast surgery population. Methods: A retrospective analysis was conducted patients who underwent with and without ciNPT a single health system over 6 years. Oncoplastic defined as conservation involving partial mastectomy immediate volume displacement or replacement techniques. Primary outcomes were rates clinically significant complications requiring either medical...
Oncoplastic surgery (OPS) is a form of breast conservation involving partial mastectomy followed by volume displacement or replacement surgery. As the field OPS growing, we sought to determine if there was learning curve this surgery.A retrospective chart review conducted all patients who underwent over 6-year period with single surgeon formally trained in both Plastic Surgery and Breast Oncology. Cumulative summation analysis (CUSUM) performed on mean operative time generate phases....
Oncoplastic breast reduction mammoplasty (ORM) is an excellent treatment option for women with cancer and macromastia undergoing conservation therapy. Here, we aim to better understand the risks associated ORM compared standard (SRM).A retrospective chart review was performed of patients or SRM from 2015 2021. Primary outcomes included occurrence major minor postoperative complications in two groups delays adjuvant therapy (>90 days) among ORM.Women group (n = 198) were significantly older...
Although the transplant outcomes of centers are heavily monitored and compared, with a particular link between posttransplant center volume demonstrated, little data exist comparing waitlist outcomes. Here, we explored by volume. We performed retrospective analysis adults listed for primary heart transplantation (HTx) from 2008 to 2018 using United Network Organ Sharing database. Transplant were split into low (<10 HTx/year), medium (10–30 high (>30 HTx/year) volume, compared. Of...
The American College of Surgeons Committee on Trauma requires that all level I trauma centers have cardiopulmonary bypass (CPB) capabilities immediately available. Despite this mandate, there are limited data the utilization and clinical outcomes among patients requiring CPB in management injuries. aim study was to evaluate current use care patients.This is a retrospective analysis National Data Bank from 2010 2015. Adult sustaining cardiothoracic injuries who underwent surgical repair...
Gastric cancer is the fourth most common worldwide and second cause of cancer-related death. The majority newly diagnosed gastric cases present either as locally advanced tumor growth or with distant metastases. Here, we describe a case isolated brain metastases in male patient cancer. Initially, our presented dysphagia was after thorough evaluation. One year chemotherapy surgical resection his cancer, he headaches, nausea, dizziness, photophobia. Further evaluation these symptoms led to...
Oncoplastic breast surgery (OBS) is a form of conservation (BCS) that involves partial mastectomy followed by immediate volume displacement or replacement surgical techniques. To date, there are few studies evaluating OBS in older patients. Therefore, we sought to determine if outcomes differed between patients 65 years and versus younger who underwent oncoplastic procedures.
Abstract This study aims to systematically review the accuracy of self-reporting conflicts interest (COIs) among studies related use dermal substitute products in burn management and evaluate factors associated with increased discrepancies. To do so, a literature search was done identify investigating substitutes published between 2015 2019. Industry payments were collected using Centers for Medicare Medicaid Services Open Payments database. Declared COIs then compared listed payments....
Iliacus compartment syndrome is a rare clinical condition which can result in severe, unilateral, femoral neuropraxia. Recognition of this as the cause developing neuropathy often delayed given lack familiarity with diagnosis and retroperitoneal location iliacus muscle. Prompt important to avoid risk consequent muscle necrosis, rhabdomyolysis, possibly permanent nerve injury. We describe case an elderly, frail woman end-stage renal disease, anticoagulated for atrial fibrillation, who...
Although rare, MitraClip embolization can be life threatening.We report the treatment of one such case as only survival to discharge in literature.Abbreviated legend for central picture: The mitraclip seen embolized right coronary artery ostium Glossary Abbreviations ASD -Atrial Septal Defect MR -Mitral Regurgitation POD -Post Operative Day RCA