A5030906845- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Systemic Sclerosis and Related Diseases
- Extracellular vesicles in disease
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Myofascial pain diagnosis and treatment
- Cardiac Valve Diseases and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Blood Pressure and Hypertension Studies
- Cardiac Health and Mental Health
- Kruppel-like factors research
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pharmacology and Obesity Treatment
- Pericarditis and Cardiac Tamponade
- Apelin-related biomedical research
- Nerve injury and regeneration
- Urticaria and Related Conditions
- Adipose Tissue and Metabolism
Medical University of Warsaw
2019-2023
Background: Sodium-glucose cotransporter 2 (SGLT2), also known as solute carrier family 5 member (SLC5A2), is a promising target for new class of drugs primarily established kidney-targeting, effective glucose-lowering agents used in diabetes mellitus (DM) patients. Increasing evidence indicates that besides renal effects, SGLT2 inhibitors (SGLT2i) have systemic impact via indirectly targeting the heart and other tissues. Our hypothesis states pleiotropic effects SGLT2i are associated with...
Aim: To analyze the functional performance of patients with generalized scleroderma treated at Department Dermatology PIM Ministry Internal Affairs and to develop recommendations for physiotherapists. Systemic sclerosis (SSc) is a chronic connective tissue disease characterized by progressive fibrosis skin internal organs, presence microcirculatory disorders autoantibodies. Materials Methods: The study group consisted 55 aged 27 years 80 (mean 56.4) systemic scleroderma, who receive...
Aim: To analyze the exercise tolerance and thoracic mobility of patients with systemic scleroderma treated at Department Dermatology PIM Ministry Internal Medicine after 2 years individually tailored rehabilitation. Materials Methods: The study group consisted 55 aged 27 to 80 (mean 56.4) scleroderma, who receive rheological treatment in on a cyclical basis. In addition, therapy was supported by rehabilitation for years. Before completed, results were analyzed. Forty-two completed project....
Aim: The study aimed to analyze hand strength in patients with systemic sclerosis treated at the Dermatology Clinic of National Medical Institute Ministry Interior and Administration, using an electronic dynamometer, over a two-year rehabilitation period. Materials Methods: group consisted 55 aged 27 80 years (average age: 56.4) sclerosis, who regularly received rheological treatment Clinic. Additionally, for two years, were supported individually selected manual exercises upper limb...
To investigate the association of liver metabolite trimethylamine N-oxide (TMAO) with cardiovascular disease (CV)-related and all-cause mortality in patients acute coronary syndrome (ACS) who underwent percutaneous intervention. Our prospective observational study enrolled 292 ACS. Plasma concentrations TMAO were measured during hospitalization for Observation period lasted seven yr median. Adjusted Cox-regression analysis was used prediction mortality. ROC curve revealed that increasing...
Aim: To objectively evaluate the range of mandibular mobility based on linear measurements in patients with generalized scleroderma treated at Department Dermatology PIM Ministry Internal Medicine, who underwent rehabilitation for 2 years. Materials and Methods: The study group consisted 55 aged 27 to 80 years (mean 56.4) systemic scleroderma, periodically received rheologic treatment Dermatology. Additionally, pharmacotherapy was supplemented individually tailored rehabilitation, including...
MicroRNAs (miRNA, miR) have an undeniable physiological and pathophysiological significance act as promising novel biomarkers. The aim of the study was to investigate blood-derived miRNAs their association with long-term all-cause mortality in patients multivessel disease (MVD) suffering from acute coronary syndrome (ACS). This observational prospective study, which included 90 MVD ACS. Expression miR-125a, miR-125b, miR-223 analysed by polymerase chain reaction (PCR). Patients were...
Aim: To analyze the hand function of patients with systemic sclerosis treated at Dermatology Clinic PIM MSWiA after a 2-year individually tailored rehabilitation program. This program consisted set manual exercises and self-massage upper limbs, performed home adapted to patient’s movement abilities. Materials Methods: The study group 55 aged 27 80 years (mean 56.4) sclerosis, who received cyclical rheological treatment Clinic. For 2 years, therapy was supported by limbs. Before therapy,...
Transcatheter aortic valve implantation (TAVI) is an established treatment for stenosis (AS) in patients at increased surgical risk. Up to 29% of annually experience major adverse cardiac and cerebrovascular events (MACCE) after TAVI. MicroRNAs (miRNA) are currently widely investigated as novel cardiovascular biomarkers. The aim this study was determine the influence TAVI on expressions selected miRNAs associated with platelet function (miR-125a-5p, miR-125b miR-223), evaluate predictive...
Abstract Background MicroRNAs (miRNAs, miR) are essential gene expression regulators involved in numerous biological processes and diseases including type 2 diabetes (DM). Purpose We aimed to determine the predictive value of selected circulating miRNAs for cardiovascular all-cause mortality their potential usefulness as biomarkers DM patients. Method Two hundred fifty-two patients with were enrolled study. Among included, 26 (10.3%) died during a median follow-up 71 months (5.9 years)....
Abstract Background SGLT2 (Solute Carrier Family 5 Member 2, SLC5A2) is a promising target of new class drugs primarily established as kidney-targeting, effective glucose-lowering agents used in diabetes mellitus (DM) patients. Rising evidence indicates that besides renal effects, inhibitors (SGLT2i) have also systemic impact via indirectly targeting the heart, endothelial cells, liver, adipose tissue. Our hypothesis states pleiotropic effects SGLT2i are associated with its binding force,...
Abstract Background Endurance training can be described as long-time activity characterized by high dynamic and low to power was proven beneficial in CVD prevention. Nevertheless, studies reported that excessive endurance act double-edged sword inducing the inflammatory response cell apoptosis. This negative effect reason of exercise duration. Purpose In order investigate duration we compared analysed acute vs chronic using silico technique performed two different bioinformatics analysis:...
Abstract Introduction Cardiovascular diseases are the leading cause of death worldwide. According to World Health Organization data, they responsible for approximately 31% deaths annually. It is estimated that nearly 80% premature CVDs preventable by modification lifestyle including regular physical activity. Endurance training can be described as long-time activity characterized high dynamic and low power was proven beneficial in CVD prevention. Several miRNAs, miR-125a-5p had been reported...
Abstract Background Stroke is the second-most common cause of death worldwide. Circulating levels selected microRNAs (miRNAs) were found to be modulated both in animal experimental models and patients with stroke, opening up new avenues for identification more effective specific biomarkers identify risk-stratify stroke patients. Aim present study all circulating miRNAs that are select used as disease improve prognosis. Methods 48 stroke- ESUS involved study. We have divided patient groups...
Abstract Introduction SARS-CoV-2 tropism for the ACE2 receptor, along with multifaceted inflammatory reaction, is likely to drive generalized hypercoagulable state seen in patients COVID-19. Methodology Using original bioinformatic workflow and network medicine approaches we reanalyzed four coronavirus-related expression datasets performed co-expression analysis focused on thrombosis related genes. We identified microRNAs (miRNAs) which play role ACE2-related coronavirus infection further,...