A5067318812- Diabetes Treatment and Management
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- MicroRNA in disease regulation
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Potassium and Related Disorders
- Pancreatic function and diabetes
- Infective Endocarditis Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- Grief, Bereavement, and Mental Health
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Complement system in diseases
- Patient Dignity and Privacy
- Platelet Disorders and Treatments
- Advanced Glycation End Products research
- Cardiac Valve Diseases and Treatments
- Cancer-related molecular mechanisms research
- Palliative Care and End-of-Life Issues
Medical University of Vienna
2019-2023
Sodium-glucose co-transporter 2 inhibition reduces the risk of hospitalization for heart failure and death in patients with symptomatic failure. However, trials investigating effects this drug class following acute myocardial infarction are lacking.
The interleukin-6 (IL-6) pathway has a crucial role in the pathogenesis of atherosclerosis, main cause cardiovascular diseases. We aimed to characterize predictive value inflammatory biomarkers on long-term mortality patients with acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI). This prospective observational study included 322 consecutive ACS PCI. Blood-derived IL-6 and high-sensitivity C-reactive protein (hsCRP) were assessed at time point ACS. Patients followed-up...
Background: Sodium–glucose co-transporter 2 (SGLT2) inhibitors are an emerging class of glucose-lowering drugs that have become increasingly relevant for the treatment and prevention heart failure (HF). Therefore, we aimed to investigate various SGLT2 in patients with established HF at baseline focused on different types HF. Methods: An extensive search PubMed Web Science until January 2021 was done. Two reviewers, independently duplicate, applied selection criteria. This meta-analysis...
Von Willebrand factor (VWF) and VIII (FVIII) circulate in a noncovalent complex blood promote primary hemostasis clotting, respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability long half-life non-human primates. This first-in-human, randomized, placebo-controlled, doubleblind trial tested the hypothesis that BT200 is well tolerated has favorable pharmacokinetic pharmacodynamic effects 112 volunteers. Participants received one of following:...
Background: MicroRNAs (miRNA, miR) are small, non-coding RNAs which have become increasingly relevant as diagnostic and prognostic biomarkers. The objective of this study was the investigation blood-derived miRNAs their link to long-term all-cause mortality in patients who suffered from non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods: This an observational prospective study, included 109 with NSTE-ACS. Analysis expression miR-125a miR-223 conducted by polymerase chain...
MicroRNAs (miRNA, miR) have an undeniable physiological and pathophysiological significance act as promising novel biomarkers. The aim of the study was to investigate blood-derived miRNAs their association with long-term all-cause mortality in patients multivessel disease (MVD) suffering from acute coronary syndrome (ACS). This observational prospective study, which included 90 MVD ACS. Expression miR-125a, miR-125b, miR-223 analysed by polymerase chain reaction (PCR). Patients were...
To investigate the long-term clinical benefit of dual antiplatelet therapy with potent P2Y12 inhibitors compared to clopidogrel in patients acute coronary syndrome (ACS).
Background The role of chronic inflammation in the pathogenesis atherosclerosis has been unequivocally proven. However, prognostic impact C-reactive protein, a marker inflammatory response patients with acute myocardial infarction not fully clarified. Furthermore, there is no direct comparison diagnostic accuracy protein and high sensitivity population. Methods In this prospective observational cohort study, 344 were enrolled. All-cause mortality was primary endpoint. Patients followed...
Abstract Background High on-treatment platelet reactivity (HTPR) remains a major problem in the acute management of ST-elevation myocardial infarction (STEMI), leading to higher rates stent thrombosis and mortality. We aimed investigate novel, prehospital treatment strategy using cangrelor tested its pharmacodynamic effects model healthy volunteers. Methods conducted dose-finding, open-label, pilot trial including 12 volunteers three ascending bolus infusions (5 mg, 10 mg 20 mg) infusion...
There is a lack of information about patients' attitudes towards and knowledge resuscitation advance care planning (ACP) in the palliative unit (PCU). The aims this study were to examine (a) topic resuscitation, (b) level education their illness (c) concept ACP.This used qualitative methodology that involved semi-structured interviews with advanced cancer patients admitted PCU. Interviews conducted during first week after admission, recorded digitally transcribed verbatim. Data analysed...
Abstract Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an emerging class of glucose lowering drugs, which become increasingly relevant for treatment and prevention heart failure (HF). Therefore we aimed to investigate various SGLT2 in patients with established HF at baseline. Design Extensive search PubMed Web Science until January 2021. Two reviewers independently duplicate applied the selection criteria. This meta-analysis was conducted according PRISMA guidelines. Data...