A5046353097- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Vasculitis and related conditions
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Myeloid Leukemia Research
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Renal Diseases and Glomerulopathies
- advanced mathematical theories
- Genomics and Chromatin Dynamics
- Social Media in Health Education
- Antiplatelet Therapy and Cardiovascular Diseases
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Eosinophilic Disorders and Syndromes
- Asthma and respiratory diseases
- Mathematical Dynamics and Fractals
- Whipple's Disease and Interleukins
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
Brigham and Women's Hospital
2021-2025
Dana-Farber Cancer Institute
2023-2025
Harvard University
2021-2025
Dana-Farber Brigham Cancer Center
2023
Washington University in St. Louis
2013-2020
Microglia contribute to development, homeostasis, and immunity of the CNS. Like other tissue-resident macrophage populations, microglia express surface receptor triggering expressed on myeloid cells 2 (TREM2), which binds polyanions, such as dextran sulphate bacterial LPS, activates downstream signaling cascades through adapter DAP12. Individuals homozygous for inactivating mutations in TREM2 exhibit demyelination subcortical white matter a lethal early onset dementia known Nasu-Hakola...
Circadian dysfunction is a common attribute of many neurodegenerative diseases, most which are associated with neuroinflammation. rhythm has been inflammation in the periphery, but role core clock neuroinflammation remains poorly understood. Here we demonstrate that Rev-erbα, nuclear receptor and circadian component, mediator microglial activation We observed time-of-day oscillation immunoreactivity hippocampus, was disrupted Rev-erbα −/− mice. deletion caused spontaneous hippocampus...
Group 3 ILCs (ILC3s) are innate sources of IL-22 and IL-17 include lymphoid tissue-inducer (LTi)-like NKp46(+) subsets. Both depend on RORγt aryl hydrocarbon receptor, but NKp46(+)ILC3s also require Notch T-bet for their development transcriptionally distinct. The extent to which these subsets have unique functions, especially in the context T cell- B cell-sufficient mice, remains largely unclear. To investigate specific function among other ILC3 cells, we generated mice selectively lacking...
Abstract The signals that maintain tissue-resident innate lymphoid cells (ILC) in different microenvironments are incompletely understood. Here we show IL-7 receptor (IL-7R) is not strictly required for the development of any ILC subset, as residual persist small intestinal lamina propria (siLP) adult and neonatal Il7ra −/− mice. ILC2 primarily express an ST2 − phenotype, but inflammatory ILC2. CCR6 + ILC3, which higher Bcl-2 than other most abundant subset siLP. All subsets functionally...
Clock protein REV-ERBα influences development of type 3 innate lymphoid cells in a circadian-independent manner (see the related Focus by Mortha and Research Article Teng et al. ).
Infections of the central nervous system (CNS) with cytopathic viruses require efficient T cell responses to promote viral clearance, limit immunopathology, and enhance survival. We found that IL-1R1 is critical for effector reactivation limits inflammation within CNS during murine West Nile virus (WNV) encephalitis. WNV-infected IL-1R1(-/-) mice display intact adaptive immunity in periphery but succumb WNV infection caused by loss virologic control depressed local Th1 cytokine responses,...
Giant cell arteritis (GCA) is an age-related vasculitis. Prior studies have identified association between GCA and hematologic malignancies (HMs). How the presence of somatic mutations that drive development HMs, or clonal hematopoiesis (CH), may influence clinical outcomes in not well understood.
During pregnancy immune cells infiltrate the placenta at different stages of fetal development. NK and macrophages are most predominant cell types. These play pleiotropic roles, as they control spiral artery remodeling to ensure appropriate blood supply maintain long term tolerance a true allograft; yet, must be able mount defenses pathogens that may threaten fetus. Whether same type accomplishes all these tasks or if there dedicated subsets remains controversial. Here we identify...
Innate lymphoid cells (ILCs) are a heterogeneous population of tissue-associated cells, particularly abundant in mucosal and barrier tissues, such as gut skin, which survey their microenvironment by perceiving rapidly responding to incoming cues. ILC heterogeneity is characterized function, while numerous soluble cell-surface factors trigger major subgroups among ILCs correspond the cytokines they produce can respond to. Major subsets comprise ILC3s, ILC2s, ILC1s, corresponding counterpart T...