A5102833848- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- Fatty Acid Research and Health
- Polyamine Metabolism and Applications
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Advanced Glycation End Products research
- Antibiotic Use and Resistance
- Supramolecular Self-Assembly in Materials
- Circular RNAs in diseases
- Metabolism and Genetic Disorders
- Yersinia bacterium, plague, ectoparasites research
- Bone Metabolism and Diseases
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Neuroscience of respiration and sleep
- Melanoma and MAPK Pathways
- Connexins and lens biology
- Peroxisome Proliferator-Activated Receptors
- High-Temperature Coating Behaviors
- Heme Oxygenase-1 and Carbon Monoxide
Jining First People's Hospital
2025
Dalian Ocean University
2021-2023
Women's Hospital, School of Medicine, Zhejiang University
2023
Chinese Academy of Fishery Sciences
2023
Ministry of Agriculture and Rural Affairs
2023
Shihezi University
2019-2022
Fujian Medical University
2008-2021
Union Hospital
2017-2021
EY Technologies (United States)
2018
China Medical University
2011
Although current chemotherapy using bortezomib (Velcade) against multiple myeloma in adults has achieved significant responses and even remission, a majority of patients will develop acquired resistance to bortezomib. Increased thioredoxin level been reported be associated with carcinogenesis; however, the role drug remains unclear. We generated several bortezomib-resistant cell lines by serially passaging increased concentrations over period 1.5 years. Thioredoxin expression was measured...
Objective: To investigate the uptake patterns of 18F-fluorodeoxy glucose (18F-FDG) in endometrium using positron emission tomography (PET) imaging and to differentiate these from stage IA endometrial cancer. Methods: From September 2022 April 2024, a prospective inclusion 354 women without gynecological diseases no hormone usage who underwent 18F-FDG PET-CT examinations at affiliated hospital Qingdao University were set as physiological group, while group containing 42 cases Stage carcinoma...
Bone metastases are common in advanced breast cancer patients and frequently leading to skeletal-related morbidity deterioration the quality of life. Although chemotherapy hormone therapy able control symptoms caused by bone destruction, underlying molecular mechanisms for affinity cells towards skeletal bones still not completely understood.In this study, bioinformatic analysis was performed on patients' microarray gene expression data explore mechanism associated with metastasis....
In this study, we investigated the molecular pathways regulating breast cancer liver metastasis. We identified 48 differentially expressed genes (4 upregulated and 44 downregulated) by analyzing microarray dataset GSE62598 from Gene Expression Omnibus (GEO). constructed a genetic interaction network with 84 nodes 237 edges using String consortium database. The was reliably robust clustering coefficient (cc) of 0.598 protein-protein (PPI) enrichment p value zero. Using Ontology Kyoto...
Tuberculosis (TB) is a globally prevalent infectious disease. The mechanisms of latent TB infection (LTBI) remain to be fully elucidated and may provide novel approaches for diagnosis. As therapeutic targets molecular diagnostic markers, microRNAs (miRs) have been studied utilized in various diseases. In the present study, differentially expressed miRs (DEMs) LTBI were screened analyzed determine underlying identify potential biomarkers, thereby contributing diagnosis LTBI. GSE25435 GSE29190...
Alginate oligosaccharides (AOs) prepared through enzymatic reaction by diverse alginate lyases under relatively controllable and moderate conditions possess versatile biological activities. But widely used commercial are still rather rare due to their poor properties (e.g., lower activity, worse thermostability, ion tolerance, etc.). In this work, the lyase Alyw208, derived from Vibrio sp. W2, was expressed in Yarrowia lipolytica of food grade characterized order obtain an enzyme with...
Chronic ethanol exposure is known to affect deacylation-reacylation of membrane phospholipids (PL). In our earlier studies we have demonstrated that chronic (EtOH) leads a progressive increase in phospholipase A2 (PLA2) activity. the current study, investigated effects EtOH on incorporation different free fatty acids (FFAs) into PL. The results suggest four major PL varied from 9.6 fmol/min/mg protein for docosahexaenoic acid (DHA) phosphatidylinositol (PI) 795.8 linoleic (LA)...
Apoptosis and inflammation have been shown to play an important role in the mechanisms involved pathogenesis of Mycobacterium tuberculosis (MTB) infection. When macrophages undergo apoptosis polarization, gap junctions (GJs) may be needed provide conditions for their functions. Connexin 43 (Cx43) connexin 37 (Cx37) are main connexins that participate formation GJ channels.An H37Rv infection RAW264.7 macrophage model was established investigate associate between host immune defense response...
Alginate lyase possesses wide application prospects for the degradation of brown algae and preparation alginate oligosaccharides, its products display a variety biological activities. Although many enzymes this type have been reported, lyases with unique properties are still relatively rare. In present work, an abbreviated as Alyw203 has cloned from Vibrio sp. W2 expressed in food-grade Yarrowia lipolytica . The gene consists open reading frame (ORF) 1,566 bp containing 521 amino acids,...
The fate of [ 14 C]ethyl‐linoleate (EthLin) after its intravenous administration was investigated in pentobarbital‐anesthetized rats. disappearance C]EthLin from the plasma very rapid and followed quite closely a biexponential function time. Fitting experimental data to two‐compartmental mammillary model revealed that labeled compounds are eliminated with half‐life <1 min during early time following injection large portion EthLin is hydrolyzed instantly linoleic acid ethanol. About 9–11 %...
More than 75% of ovarian cancer patients are diagnosed at advanced stages and die tumor cell metastasis. This study aimed to identify new epigenetic transcriptomic alterations associated with metastasis.Two sublines low- high-metastasis potentials were derived from the line A2780. Genome-wide DNA methylome transcriptome profiling carried out in these two by Reduced Representation Bisulfite Sequencing RNA-seq technologies. Cell-based assays conducted support clinical findings.There distinct...
Synuclein-γ (SNCG) and Snai1 play an important role in the occurrence development of different types malignant tumors. However, association between SNCG effect their combination on oral squamous cell carcinoma (OSCC) are unknown. The purpose this study was to assess expression OSCC tissues genesis, development, diagnosis, prognosis OSCC. In study, we first analyzed Gene Expression Omnibus (GEO) database determine And also evaluated correlation clinical pathological parameters from Cancer...
Objective: To study the distribution and drug resistance of Carbapenem-Resistant Organism (CRO) to analysis risk factors CRO 30-day mortality. Methods: A total 181 patients with infection diagnosed in Department Hematology, Fujian Medical University Union Hospital from January 2018 June 2020 were retrospectively investigated. The clinical laboratory data collected, prognosis day 30 was followed up, analyzed. significance Enterobacteriaceae (CRE) active screening further evaluated CRE...
Ion implantation, ion beam mixing, and enhanced deposition (IBED) were employed to improve oxidation resistance of intermetallic compound Ni3Al(0.1B) in pure flowing oxygen at temperature 1100 K. X-ray diffraction scanning electron microscopy used examine the composition structure scales after oxidation. Improved was observed Ta+-implanted, mixed Si layers, IBED films coated specimens. The possible mechanisms for these effects discussed.