A5102019315- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Cancer-related gene regulation
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Cancer Research and Treatments
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Sesquiterpenes and Asteraceae Studies
- Traditional and Medicinal Uses of Annonaceae
- Ubiquitin and proteasome pathways
- Mass Spectrometry Techniques and Applications
Women's Hospital, School of Medicine, Zhejiang University
2023
Purdue University West Lafayette
2022
University of California, Davis
2020
Guangdong Provincial People's Hospital
2007
More than 75% of ovarian cancer patients are diagnosed at advanced stages and die tumor cell metastasis. This study aimed to identify new epigenetic transcriptomic alterations associated with metastasis.Two sublines low- high-metastasis potentials were derived from the line A2780. Genome-wide DNA methylome transcriptome profiling carried out in these two by Reduced Representation Bisulfite Sequencing RNA-seq technologies. Cell-based assays conducted support clinical findings.There distinct...
Abstract UDP-glucose pyrophosphorylase 2 (UGP2) is a lynchpin metabolic enzyme that rests at the convergence of multiple pathways regulating both glycogen synthesis and glycosylation modifications. Here we elucidated essential role UGP2-mediated in maintenance KRAS-driven cancer using vitro vivo models. A key effector KRAS oncogenic function transcription factor YAP. We identified YAP/TEAD complex as major regulator UGP2 mRNA expression enzymatic activity genomic perturbations, correlative...