A5041034837- Gene expression and cancer classification
- Bayesian Modeling and Causal Inference
- Bioinformatics and Genomic Networks
- Urinary Bladder and Prostate Research
- Gene Regulatory Network Analysis
- Pelvic floor disorders treatments
- Estrogen and related hormone effects
- Urinary Tract Infections Management
- Trace Elements in Health
- AI-based Problem Solving and Planning
- HIV Research and Treatment
- MicroRNA in disease regulation
- Carcinogens and Genotoxicity Assessment
- Glioma Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Data Quality and Management
- HIV/AIDS Research and Interventions
- RNA Research and Splicing
- Genetics, Bioinformatics, and Biomedical Research
- Optimal Experimental Design Methods
- Circular RNAs in diseases
- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Prostate Cancer Diagnosis and Treatment
Florida International University
2016-2025
Seoul Metropolitan Government
2022
Seoul National University
2022
Boramae Medical Center
2022
Medical College of Wisconsin
2014
University of Pittsburgh
1999-2013
Cancer Research And Biostatistics
2013
University of Montana
2004-2009
Virginia Tech
2003
In this study we have identified key genes that are critical in development of astrocytic tumors. Meta-analysis microarray studies which compared normal tissue to astrocytoma revealed a set 646 differentially expressed the majority astrocytoma. Reverse engineering these using Bayesian network analysis produced gene for each grade (Grade I-IV), and 'key genes' within were identified. Genes found be most influential highest astrocytoma, Glioblastoma multiforme were: COL4A1, EGFR, BTF3, MPP2,...
17β-Oestradiol (E2)-induced reactive oxygen species (ROS) have been implicated in regulating the growth of breast cancer cells. However, underlying mechanism this is not clear. Here we show how ROS through a novel redox signalling pathway involving nuclear respiratory factor-1 (NRF-1) and p27 contribute to E2-induced MCF-7 Chromatin immunoprecipitation, qPCR, mass spectrometry, western blot, colony formation, cell proliferation, assay, immunofluorescence microscopy were used study role...
Prostate cancer (PCa) is one of the leading malignant tumors in US men. The lack understanding molecular pathology on risk food supply chain exposures environmental phenol (EP) and paraben (PB) chemicals limits prevention, diagnosis, treatment options. This research aims to utilize a assessment approach demonstrate association EP PB detected urine samples along with PCa men (NHANES data 2005−2015). Further, we employ integrated bioinformatics examine how exposure influences pathways...
Abstract Background HIV infection and drugs of abuse such as methamphetamine (METH), cocaine, alcohol use have been identified risk factors for triggering inflammation. Acute phase proteins C-reactive protein (CRP) serum amyloid A (SAA) are the biomarkers Hence, interactive effect with acute in HIV-positive subjects was investigated. Methods Plasma samples were utilized from 75 METH use, cocaine alone METH, users, age-matched control subjects. The plasma CRP SAA levels measured by ELISA...
This cross-sectional study examined the physical and mental health, grief role functioning of 136 grandparents in first year after death their young grandchild (newborn through 6 years). Grandparents were 36–77 years old; 73 % female; 24 Hispanic, 38 Black/African American, White. Mean age 115 deceased grandchildren was 12.8 months (SD = 20.71) with 37 <1 month 65 male, 77 died hospital. recruited state records interviewed by telephone. experienced: clinical depression (31 %), PTSD (35 %);...
Describe changes in mothers' and fathers' grief from 1 to 13 months after infant/child neonatal/pediatric intensive care unit death identify factors related their grief.Mothers (n = 130) fathers 52) of 140 children (newborn-18 years) completed the Hogan Grief Reaction Checklist at 1, 3, 6, post-death.Grief decreased 3 for mothers 6 fathers. was more intense for: deceased adolescents whose child declared brain dead.Mothers' intensity may not coincide, resulting different needs during death.
Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder caused by mutations in the SERPINA1 gene, leading to reduced levels or impaired function of alpha-1 (AAT). This condition predominantly affects lungs and liver. The Z allele, specific mutation most severe form results production misfolded AAT proteins. peptides accumulate endoplasmic reticulum (ER) liver cells, triggering ER stress activating unfolded protein response (UPR), cellular mechanism designed restore homeostasis....
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder caused by mutations in the SERPINA1 gene, leading to reduced levels or impaired alpha-1 (AAT) function. This condition predominantly affects lungs and liver. The Z allele, specific mutation most severe form results production of misfolded AAT proteins. proteins accumulate endoplasmic reticulum (ER) liver cells, triggering ER stress activating unfolded protein response (UPR), cellular mechanism designed restore...
Prostate cancer (PCa) is one of the most frequently diagnosed cancers among men in world. Its prevention has been limited because an incomplete understanding how environmental exposures to chemicals contribute molecular pathogenesis aggressive PCa. Environmental endocrine-disrupting (EDCs) may mimic hormones involved PCa development. This research aims identify EDCs associated with hub genes and/or transcription factors (TF) these addition their protein-protein interaction (PPI) network. We...
Relaxin, a small peptide hormone of the insulin/relaxin family, demonstrated antifibrotic, organ protective, vasodilatory, and proangiogenic properties in clinical trials several animal models human diseases. Relaxin family receptor 1 (RXFP1) is relaxin cognate G protein-coupled receptor. We have identified series molecule agonists RXFP1. The lead compound ML290 preferred absorption, distribution, metabolism, excretion profiles, easy to synthesize, has high stability vivo. However, does not...
Purpose To identify non-invasive clinical parameters to predict urodynamic bladder outlet obstruction (BOO) in patients with benign prostatic hyperplasia (BPH) using causal Bayesian networks (CBN). Subjects and Methods From October 2004 August 2013, 1,381 eligible BPH complete data were selected for analysis. The following variables considered: age, total prostate volume (TPV), transition zone (TZV), specific antigen (PSA), maximum flow rate (Qmax), post-void residual (PVR) on uroflowmetry,...