A5091194969- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- Hippo pathway signaling and YAP/TAZ
- CAR-T cell therapy research
- Cancer Research and Treatments
- Circular RNAs in diseases
- Axon Guidance and Neuronal Signaling
- Cytokine Signaling Pathways and Interactions
- Mechanisms of cancer metastasis
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Connective Tissue Growth Factor Research
- interferon and immune responses
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Melanoma and MAPK Pathways
- Apelin-related biomedical research
- Ferroptosis and cancer prognosis
- Macrophage Migration Inhibitory Factor
- Cell death mechanisms and regulation
- Phagocytosis and Immune Regulation
- Nuclear Receptors and Signaling
- RNA modifications and cancer
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
Virginia Commonwealth University
2016-2025
VCU Massey Comprehensive Cancer Center
2009-2024
Institute of Molecular Medicine
2008-2023
Columbia University Irving Medical Center
2004-2023
Virginia Commonwealth University Medical Center
2002-2022
Virginia Cancer Institute
2011-2019
University of Richmond
2011-2015
Indiana University School of Medicine
2014-2015
University of Iowa
2015
Institute of Molecular Genetics
2014
Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by diverse etiology, activation of multiple signal transduction pathways, and various gene mutations. Here, we have determined specific role for astrocyte elevated gene-1 (AEG1) in HCC pathogenesis. Expression AEG1 was extremely low human hepatocytes, but its levels were significantly increased HCC. Stable overexpression converted nontumorigenic cells into tumors, inhibition abrogated tumorigenesis xenograft...
Glutamate is an essential neurotransmitter regulating brain functions. Excitatory amino acid transporter (EAAT)-2 one of the major glutamate transporters primarily expressed in astroglial cells. Dysfunction EAAT2 implicated acute and chronic neurological disorders, including stroke/ischemia, temporal lobe epilepsy, amyotrophic lateral sclerosis, Alzheimer disease, human immunodeficiency virus 1-associated dementia, growth malignant gliomas. Ceftriaxone, beta-lactam antibiotics, a stimulator...
Hepatocellular carcinoma (HCC) presents a significant global health threat, particularly in regions endemic to hepatitis B and C viruses, because of the ongoing pandemic obesity causing metabolic-dysfunction-related fatty liver disease (MAFLD), precursor HCC. The molecular intricacies HCC, genetic epigenetic alterations, dysregulated signaling pathways facilitate personalized treatment strategies based on profiling. Epigenetic regulation, encompassing DNA methyltion, histone modifications,...
Subtraction hybridization identified melanoma differentiation-associated gene-7 (mda-7) as a gene induced during terminal differentiation in human cells. On the basis of structure, chromosomal localization and cytokine-like properties, mda-7 is classified IL-24. Administration mda-7/IL-24 by means replication-incompetent adenovirus (Ad.mda-7) induces apoptosis selectively diverse cancer cells without inducing harmful effects normal fibroblast or epithelial The present studies investigated...
Abstract Astrocyte elevated gene-1 (AEG-1) was initially identified as an HIV-1- and tumor necrosis factor α (TNF-α)–inducible transcript in primary human fetal astrocytes by a rapid subtraction hybridization approach. Interestingly, AEG-1 expression is subsets of breast cancer, glioblastoma multiforme melanoma cells cooperates with Ha-ras to promote transformation immortalized melanocytes. Activation the transcription nuclear κB (NF-κB), TNF-α downstream signaling component, associated...
Malignant glioma is a consistently fatal brain cancer. The tumor invades the surrounding tissue, limiting complete surgical removal and thereby initiating recurrence. Identifying molecules critical for invasion essential to develop targeted, effective therapies. expression of astrocyte elevated gene-1 (AEG-1) increases in malignant AEG-1 regulates vitro migration cells by activating nuclear factor-kappaB (NF-kappaB) signaling pathway. present studies elucidate domains important mediating its...
It is well established that Ha-ras and c-myc genes collaborate in promoting transformation, tumor progression, metastasis. However, the precise mechanism underlying this cooperation remains unclear. In present study, we document astrocyte elevated gene-1 (AEG-1) a downstream target molecule of c-myc, mediating their tumor-promoting effects. AEG-1 expression diverse neoplastic states, it cooperates with to promote its overexpression augments invasion transformed cells, demonstrating...
Glutamate transport is central to neurotransmitter functions in the brain. Impaired glutamate induces neurotoxicity associated with numerous pathological processes, including stroke/ischemia, temporal lobe epilepsy, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's HIV-1-associated dementia, and growth of malignant gliomas. Excitatory amino acid transporter-2 (EAAT2) a major transporter brain expressed primarily astrocytes. We presently describe cloning characterization human...
Astrocyte-elevated gene-1 (AEG-1) expression is increased in multiple cancers and plays a central role Ha-ras-mediated oncogenesis through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Additionally, overexpression of AEG-1 protects primary transformed human rat cells from serum starvation-induced apoptosis activation PI3K/Akt signaling. These findings suggest, but do not prove, that may function as an oncogene. We now provide definitive evidence indeed transforming oncogene...
ABSTRACT Infections with RNA viruses are sensed by the innate immune system through membrane-bound Toll-like receptors or cytoplasmic helicases RIG-I and MDA-5. It is believed that MDA-5 crucial for sensing infections picornaviruses, but there have been no studies on role of this protein during infection poliovirus, prototypic picornavirus. Beginning at 4 h postinfection, degraded in poliovirus-infected cells. Levels declined beginning 6 after rhinovirus type 1a encephalomyocarditis virus,...