A5053822484- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Face Recognition and Perception
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Action Observation and Synchronization
- EEG and Brain-Computer Interfaces
- Meta-analysis and systematic reviews
- Advanced Neuroimaging Techniques and Applications
- Visual Attention and Saliency Detection
- Transcranial Magnetic Stimulation Studies
- Multisensory perception and integration
- Musculoskeletal pain and rehabilitation
- Health Policy Implementation Science
- Pain Management and Placebo Effect
- Lysosomal Storage Disorders Research
- Motor Control and Adaptation
- Language, Discourse, Communication Strategies
- Neuroscience and Music Perception
- Calcium signaling and nucleotide metabolism
- CCD and CMOS Imaging Sensors
- Digital Radiography and Breast Imaging
Maastricht University
2016-2025
Maricopa County Department of Public Health
2025
Netherlands Institute for Neuroscience
2013-2024
Imaging Center
2007-2024
Royal Netherlands Academy of Arts and Sciences
2012-2022
Daikin (United States)
2021
University of Exeter
2011-2018
Kiel University
2013-2015
Waters (United States)
2015
Santa Maria Nuova Hospital
2014
Funnel plots, and tests for funnel plot asymmetry, have been widely used to examine bias in the results of meta-analyses. asymmetry should not be equated with publication bias, because it has a number other possible causes. This article describes how interpret recommends appropriate tests, explains implications choice meta-analysis model
Primary vision segregates information along 2 main dimensions: orientation and spatial frequency (SF). An important question is how this primary visual integrated to support high-level representations. It generally assumed that the carried by different SF combined following a coarse-to-fine sequence. We directly addressed assumption investigating network of face-preferring cortical regions processes distinct over time. Face stimuli were flashed during 75, 150, or 300 ms masked. They filtered...
Perception of visual stimuli improves with training, but improvements are specific for trained rendering the development generic training programs challenging. It remains unknown to which extent low-level features transfers high-level perception, and whether this is accompanied by neuroplastic changes. The current Event-Related Potential study showed that training-induced increased sensitivity a feature, namely low spatial frequency (LSF), alters neural processing feature in stimuli....
Here we report the first quantitative analysis of spiking activity in human early visual cortex. We recorded multi-unit from two electrodes area V2/V3 a patient implanted with depth as part her treatment for epilepsy. observed well-localized receptive fields tunings contrast, orientation, spatial frequency, and size, similar to those reported macaque. also pronounced gamma oscillations local-field potential that could be used estimate underlying response properties. Spiking responses were...
The ability to maintain a sequence of items in memory is fundamental cognitive function. In the rodent hippocampus, representation sequentially organized spatial locations reflected by phase action potentials relative theta oscillation (phase precession). We investigated whether timing neuronal activity brain also reflects order medial temporal lobe humans. used task which human participants learned fixed pictures and recorded single neuron local field potential with implanted electrodes....
The Lysosomal Associated Membrane Protein type-2 (LAMP-2) is an abundant lysosomal membrane protein with important role in immunity, macroautophagy (MA) and chaperone-mediated autophagy (CMA). Mutations within the Lamp2 gene cause Danon disease, X-linked storage disorder characterized by (cardio)myopathy intellectual dysfunction. pathological hallmark of this disease accumulation glycogen autophagic vacuoles cardiac skeletal muscle that, along myopathy, also present LAMP-2-deficient mice....
Abstract Despite growing interest, the causal mechanisms underlying human neural network dynamics remain elusive. Transcranial Magnetic Stimulation (TMS) allows to noninvasively probe excitability, while concurrent fMRI can log induced activity propagation through connected nodes. However, this approach ignores ongoing oscillatory fluctuations which strongly affect excitability and concomitant behavior. Here, we show that TMS-EEG-fMRI enables precise direct monitoring of dependencies between...
An indispensable feature of episodic memory is our ability to temporally piece together different elements an experience into a coherent memory. Hippocampal time cells—neurons that represent temporal information—may play critical role in this process. Although these cells have been repeatedly found rodents, it still unclear what extent similar selectivity exists the human hippocampus. Here, we show context modulates firing activity hippocampal neurons during structured experiences. We...
Abstract If we search for an item, a representation of this item in our working memory guides attention to matching items the visual scene. We can hold multiple memory. Do all these guide parallel? asked participants detect target object stream objects while they maintained second subsequent task. On some trials, presented as distractor stream. Subjects did not confuse with target, false alarm rate on trials where was comparable that only regular distractors. However, performance does...
Abstract Neuronal processes underlying the formation of new associations in human brain are not yet well understood. Here participants, implanted with depth electrodes brain, learned arbitrary between images presented an ordered, predictable sequence. During learning we recorded from medial temporal lobe (MTL) neurons that responded to at least one pictures sequence (the preferred stimulus). We report as a result learning, single MTL show asymmetric shifts activity and start firing earlier...
A sound of interest may be tracked amid other salient sounds by focusing attention on its characteristic features including frequency. Functional magnetic resonance imaging findings have indicated that frequency representations in human primary auditory cortex (AC) contribute to this feat. However, attentional modulations were examined at relatively low spatial and spectral resolutions, frequency-selective contributions outside the AC could not established. To address these issues, we...
Brain-computer interfaces (BCIs) based on real-time functional magnetic resonance imaging (rtfMRI) are currently explored in the context of developing alternative (motor-independent) communication and control means for severely disabled. In such BCI systems, user encodes a particular intention (e.g., an answer to question or intended action) by evoking specific mental activity resulting distinct brain state that can be decoded from fMRI activation. One goal this is increase degrees freedom...
During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words. To minimize repetition utterance length, languages use pronouns, like "she," refer nouns phrases were previously introduced. It has been suggested language comprehension requires pronouns activate same neuronal representations as themselves. We recorded from individual neurons in human hippocampus during a reading task. Cells...
Objectives To identify and understand, through data from multiple sources, some of the factors that affect authors' editors' decisions to use reporting guidelines in publication health research. Design Mixed methods study comprising an online survey semi-structured interviews with a sample authors (online survey: n = 56; response rate 32%; interviews: 5) journal editors 43; 27%; 6) involved publishing medical Participants were recruited earlier examining effectiveness TREND guideline....
During visual search, the working memory (WM) representation of search target guides attention to matching items in scene. However, we can hold multiple WM. Do all these guide at same time? Using a new functional magnetic resonance imaging paradigm, found that WM attain two different states influence activity extrastriate cortex opposite directions: whereas item enhanced processing input, other “accessory” suppressed activity. These results imply task-relevant and (currently) task-irrelevant...