The functions of the hypothalamic adrenal cortical and sympathetic medullary systems were studied in rats with inherited stress-induced arterial hypertension (ISIAH strain). A characteristic feature ISIAH strain is an increase blood pressure measured both under basal conditions after restraint stress particular. In control rats, plasma ACTH concentration was slightly lower than that normotensive Wistar albino Glaxo (WAG) no differences found corticosterone. However, 0.5-h produced higher...

Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects are associated with a severe decline L-arginine bioavailability, which leads to nitric oxide synthase substrate insufficiency, uncoupling, and, eventually, superoxide anion generation substantial reduction (NO) synthesis. In cooperation, it contributes chronic oxidative stress endothelial...

Norepinephrine (NE) and epinephrine (Epi) concentrations in arterial plasma skin tissue were measured chromatographically before after external cooling. Urethan-anesthetized rats cooled either slowly (0.004-0.006 degrees C/s) or rapidly (0.03- 0.05 C/s). Blood samples drawn three times from each animal: 1) cooling at a rectal temperature decreased 2) by 0.5 C 3) 3-4 C. Skin taken controls lowered The resting mean values 36.7 +/- 0.3 for temperature, 0.62 0.079 1. 09 0.203 ng/ml NE Epi, 85.6...

The diversity of pathogenetic mechanisms underlying arterial hypertension leads to the necessity devise a personalized approach diagnosis and treatment disease. Metabolomics is one promising methods for medicine, as it provides comprehensive understanding physiological processes occurring in body. metabolome set low-molecular substances available detection sample representing intermediate final products cell metabolism. Changes content ratio metabolites mark corresponding by highlighting...

Abstract The effect of a lack the gene encoding monoamine oxidase A (MAO A) in transgenic Tg8 mice on activity tryptophan hydroxylase (TPH), rate‐limiting enzyme serotonin (5‐HT) biosynthesis, and levels 5‐HT 5‐hydroxyindoleacetic acid (5‐HIAA) midbrain, hypothalamus, hippocampus, striatum, amygdala, frontal cortex was studied. It shown that with genetic MAO knockout differed from initial C3H/HeJ strain having higher level lower its metabolite, 5‐HIAA, all brain regions but cortex, where...

Objective: Association between stress and hypertensive disease is still a matter of debate. Can be the cause and, if so, what mechanisms are involved? To clarify this question, Inherited stress-induced arterial rat strain (ISIAH strain) with related hypertension was developed by selection for enhanced blood pressure response to 0.5 h restraint stress. The main intention work confirm that adrenals link disease. Methods: Hypertensive ISIAH normotensive WAG rats have been studied. in vivo...

The relationship between activation of the sympathetic nervous system and cardiac hypertrophy has long been known. However, molecular genetic basis this association is poorly understood. Given known role hypothalamic norepinephrine in system, aim work was to carry out mapping using Quantitative Trait Loci (QTL) analysis determine loci associated both with an increase concentration hypothalamus heart mass Inherited Stress-Induced Arterial Hypertension (ISIAH) rats simulating stress-sensitive...

Cardioprotective effect of resveratrol and resveratroloside was determined in ischemia-reperfusion experiments on rats. It found that single intraperitoneal administration any compound (10 mg/kg) followed by 30-min ischemia 120-min reperfusion resulted statistically significant decrease myocardial infarct area (55.0±4.0% for control group; 40.7±4.4% the group 1 received resveratrol; 41.6±4.8% 2 resveratroloside). The cardioprotective detected first time.

An experimental mouse model of dyslipidemia and atherosclerosis was utilized to study the generation methylarginines in vivo, as well any potential behavioral changes mice associated with production excess methylarginines. Following 14 weeks poloxamer 407 treatment, developed plasma concentrations monomethylarginine asymmetric dimethylarginine were found be significantly greater than corresponding control mice. This finding may have contributed development aortic atherosclerotic lesions...

The effect of a lack the gene encoding monoamine oxidase A (MAO A) in transgenic Tg8 mice on levels norepinephrine (NE), dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) midbrain, hypothalamus, hippocampus, striatum, amygdala, frontal cortex was studied. It shown that with genetic MAO knockout differed from those initial C3H/HeJ strain by higher level NE all brain regions but cortex. increased lower its metabolite DOPAC decreased DOPAC/DA ratio striatum found. There were no changes...

Recently, a study published in “Toxicology In Vitro” (Kate Samardzic and Kenneth J. Rodgers) was entitled: “Cytotoxicity Mitochondrial Dysfunction Caused by the Dietary Supplement L-Norvaline”. The title may be greatly overstated, here we provide several arguments showing that norvaline is not as toxic reported.

Abstract Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects are associated with a severe decline L-arginine bioavailability, which leads to nitric oxide synthase substrate insufficiency, uncoupling, and, eventually, superoxide anion generation substantial reduction (NO) synthesis. In cooperation, it contributes chronic oxidative stress...

to study effect of norepinephrine reuptake blockade in reperfusion period on size infarct caused by local ischemia with and without ischemic pre- postconditioning.Wistar rats (n=46) were randomly divided into 6 groups. Group (gr) I (n=7) - 30 min occlusion left coronary artery followed 120 reperfusion; gr II (n=2) as +desipramine (0.8 mg/kg intravenously [i.v.]) at the start III (n=6) preconditioning before occlusion; IV (n=7).