A5062382930- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Neuropeptides and Animal Physiology
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neural Engineering
- Human Health and Disease
- Ginkgo biloba and Cashew Applications
- Lipid Membrane Structure and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Phosphodiesterase function and regulation
- Cannabis and Cannabinoid Research
- Renin-Angiotensin System Studies
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Nanopore and Nanochannel Transport Studies
- Neurological disorders and treatments
- Enzyme Production and Characterization
Scientific Research Institute of Biochemistry
2023
Scientific Research Institute of Experimental and Clinical Medicine
2021
Institute of Physiology and Basic Medicine
2016-2020
Research Institute of Physiology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences
1995-2017
Russian Academy of Sciences
1984-2013
Academy of Medical Sciences
1977-2013
Institut Curie
2006
Centre National de la Recherche Scientifique
2006
Southern Federal University
1990
Institute of Bioorganic Chemistry
1971-1972
Functional foods enriched with plant polyphenols and anthocyanins in particular attract special attention due to multiple beneficial bioactive properties of the latter. We evaluated effects a grain diet rich mouse model Alzheimer’s disease induced by amyloid-beta (Aβ) transgenic Parkinson’s (PD) overexpression human alpha-synuclein. The mice were kept at that consisted wheat near isogenic lines differing anthocyanin content for five–six months. anthocyanin-rich was safe possessed positive on...
Functional nutrition is a valuable supplementation to dietary therapy. foods are enriched with biologically active substances. Plant polyphenols attract particular attention due multiple beneficial properties attributed their high antioxidant and other biological activities. We assessed the effect of grape on life span C57BL/6 mice behavioral neuroinflammatory alterations in transgenic mouse model Parkinson disease (PD) overexpression A53T-mutant human α-synuclein. were given supplement...
Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and atherosclerosis. In experimental models of the correction autophagy brain reverses neuronal behavioral deficits hence seems to be a promising therapy for neuropathologies. Our aim was study effect an inducer, trehalose, on behavior genetic model with signs damage (db/db mice). A 2% trehalose solution administered as drinking water during 24 days experiment. Expressions markers (LC3-II),...
In the treatment of experimental neurodegeneration with disaccharide trehalose, various regimens are used, predominantly a 2% solution, drunk for several weeks. We studied effects different dietary trehalose in an amyloid-β (Aβ) 25–35-induced murine model Alzheimer’s disease (AD). Aβ-treated mice received solution daily, 4% daily (continuous mode) or every other day (intermittent mode), to drink two revealed dose-dependent on autophagy activation frontal cortex and hippocampus, restoration...
Ceftriaxone (CEF) is a safe and multipotent antimicrobial agent that possesses neuroprotective properties. Earlier, we revealed the restoration of cognitive function in OXYS rats with signs Alzheimer's disease (AD)-like pathology by CEF along its modulating expression genes related to system amyloid beta (Aβ) metabolism brain. The aim this study was determine effects on behavior, Aβ deposition, associated neuroinflammation using another model an early AD-like induced Aβ. Mice were injected...
Chronic administration of the poloxamer 407 (P-407), a block copolymer, to elevate serum lipids in mice is well-established mouse model hyperlipidemia and atherosclerosis. We tested hypothesis that activity several types proteases heart liver tissue changed early stages atherosclerosis development. Additionally, we evaluated whether increased would induce anxiety mice, as determined by using 'plus-maze' test. The were administered P-407 intraperitoneal injection twice week for one month....
Depressive disorder is the most common psychopathology that can coexist with other mental illnesses such as post-traumatic stress disorder. It has been shown there are gender differences in susceptibility to these psychopathologies. Mice of mutant strain Disc1-Q31L characterized by depressive-like behavior and disruption molecular pathways involved processes associated fear memory. Gender interstrain learning extinction conditioned response passive avoidance were studied male female mice...