A5086990025- Optical Systems and Laser Technology
- Astronomical Observations and Instrumentation
- Inertial Sensor and Navigation
- Advanced Measurement and Detection Methods
- Infrared Target Detection Methodologies
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Simulation and Modeling Applications
- Real-time simulation and control systems
- Robotics and Sensor-Based Localization
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Immune Cell Function and Interaction
- Molecular Sensors and Ion Detection
- Genomics, phytochemicals, and oxidative stress
- Sexuality, Behavior, and Technology
- Calibration and Measurement Techniques
- Electrochemical sensors and biosensors
- Video Surveillance and Tracking Methods
- Ginseng Biological Effects and Applications
- Advanced Sensor and Control Systems
- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- Catalytic Alkyne Reactions
- Monoclonal and Polyclonal Antibodies Research
China Pharmaceutical University
2021-2024
The First People's Hospital of Guiyang
2023
Hebei University
2022
Jining Medical University
2019
Dalian Medical University
2015
Second Affiliated Hospital of Dalian Medical University
2015
Inhibition of the PD-1/PD-L1 interaction through small-molecule inhibitors is a promising therapeutic approach in cancer immunotherapy. Herein, we utilized BMS-202 as lead compound to develop series novel with naphthyridin scaffold. Among these compounds, X14 displayed most potent inhibitory activity for (IC50 = 15.73 nM). Furthermore, exhibited good binding affinity both human PD-L1 (KD 14.62 nM) and mouse 392 In particular, showed favorable pharmacokinetic properties (oral bioavailability,...
Blockade of the programmed cell death 1 (PD-1)/programmed death-ligand (PD-L1) interaction is currently focus in field cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes treatment. Despite this achievement, mAbs-based therapies are struggling with limitations including poor tissue tumor penetration, long half-life time, oral bioavailability, expensive production costs, which prompted a shift towards development small-molecule inhibitors...
A palladium-catalyzed aza-Wacker cyclization of O -homoallyl benzimidates was developed to afford a variety 4-methylene-1,3-oxazines, which are easily manipulated give family heteroatom-rich functionalized molecules.
Pathological gambling leaves seriously negative impacts on individuals, families, and society. With the universal use of internet, online disorder is also increasing worldwide. However, there currently a lack effective treatments, especially medical for disorder. This study shared 3 cases that was treated with combined fluoxetine risperidone to provide an option treatment gambling.
The star sensor simulation system is used to test the performance on ground, which designed for identification and spacecraft attitude determination of spacecraft. computer scene based astronomical chat generated hardware-in-the-loop using by OpenGL.
The first and most essential capability a visible scene projection system must have is low background high contrast during dynamic simulation. A complex was developed to meet the above requirements. mainly consists of optical fiber subsystem, LCD (Liquid Crystal Display) multiple focal plane coupler collimation objective. design build details characterization prototype projector were summarized.
Infrared resistor arrays perform a vital role in the hardware loop testing of infrared seekers. composed large numbers suspended elements are commonly used to produce dynamic two-dimensional images radiation. Due inconsistencies fabrication process arrays, temperature each reaches for given input voltage is variable and this leads more significant radiance differences, these differences result spatially-distributed non-uniformity. Therefore, order obtain an available image, non-uniformity...
The star sensor simulation system is uesed to test the performance on ground,which designed for identification and spacecraft attitude determnation of spacecraft. computer scene based astronomical chat generated hardware-in-the-loop using by openGL.
The starlight navigation is considered to be one of the most important methods for spacecraft navigation. Starlight simulation system a high-precision with large fields view, designed test sensor performance on ground. A complete hardware-in-the-loop has been built. simulator made up light source, source controller, filter, LCD, collimator and control computer. LCD key display component system, installed at focal point collimator. For cannot emit itself, so power controller specially...
The resistor array devices are commonly used to produce dynamic two dimensional infrared images in the scene projectors. A non-uniformity caused by many factors is main source of image fixed pattern noise projectors based on devices. prior correction procedure must be done before generation for hardware-in-the-loop simulation test and evaluation. In this paper, developments details technologies projector investigated. research commenced directed towards understanding cause...
IR projectors applied in HWIL simulations are responsible for generating a radiometric output which is similar to the imager real world targets and background desired wavelength seeker under test. Projector technologies meet more challenge as seekers performances improving. A variety of has been constructed satisfy different use. This paper describes three include dual-band extended source projector, MWIR Digital Micromirror Device(DMD) projector LWIR resistive array projector.
With the increase in application of celestial navigation as well advances computer graphics technology, modeling and simulation background is widely used ground-testing navigation. Celestial designed for star identification confirmation satellite attitudes space. A new technology based on dual-star-sensor sake high accuracy reliability. Two star-sensors are set satellite, there an angle between light axis these two star-sensors. So pointed to different direction Modeling which displays...
The star sensor simulation system is used to test the performance on ground, which designed for identification and spacecraft attitude determination of spacecraft. computer scene based astronomical chat generated hardware-in-the-loop using OpenGL. results generation are shown in this paper applied real time simulation.
Starlight navigation technology is widely used in spacecraft. Celestial designed for star identification and confirmation of satellite attitudes the space. Sensors celestial require hardware-in-the-loop simulation system ground-testing. A new based on dual-star-sensor sake high accuracy reliability. Hardware-in-the-loop ground-testing generates two scenes projects them into dual-star-sensors during process by real-time graphics technologies according to satellite's orientation.
The starlight navigation is considered to be one of the most important methods for spacecraft navigation. Starlight simulator system a high-precision with large fields view, designed test sensor performance on ground. A complete simulation has been built. testing consists star simulator, scene generation computer, control computer. made up power module, light source, LCD, display circuitry, optical collimator and computer interface. LCD are key component simulator.