The recent progress made in the bioengineering of cardiac patches offers a new therapeutic modality for regenerating myocardium after myocardial infarction (MI). We present here strategy engineering patch with mature vasculature by heterotopic transplantation onto omentum. was constructed seeding neonatal cells mixture prosurvival and angiogenic factors into an alginate scaffold capable factor binding sustained release. After 48 h culture, vascularized 7 days on omentum, then explanted...

Abstract STUDY QUESTION What are the perceptions of infertility patients and factors correlating with their psychological distress, following suspension fertility treatments during Corona Virus Disease-19 (COVID-19) pandemic? SUMMARY ANSWER Most preferred to resume treatment given chance regardless background characteristics; higher self-mastery greater perceived social support were associated lower while feeling helpless was distress. WHAT IS KNOWN ALREADY Infertility diagnosis frequently...

Does prior severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women undergoing fertility treatments affect the outcomes of fresh ART cycles?SARS-CoV-2 does not treatment outcomes, except for a possible long-term negative effect on oocyte yield (>180 days postinfection).A single previous study suggested no evidence that history asymptomatic or mild SARS-CoV-2 females caused impairment outcomes.Retrospective cohort study, including all infected who underwent cycles...

The development of covid-19 vaccinations represents a notable scientific achievement. Nevertheless, concerns have been raised regarding their possible detrimental impact on male fertility OBJECTIVE: To investigate the effect BNT162b2 (Pfizer) vaccine semen parameters among donors (SD).Thirty-seven SD from three sperm banks that provided 216 samples were included in retrospective longitudinal multicenter cohort study. vaccination two doses, and completion was scheduled 7 days after second...

The signals initiating growth of primordial follicles are unknown. Bone morphogenetic protein 15 (BMP15) and differentiating factor 9 (GDF9) promising candidates. objective the study was to evaluate for first time effects human recombinant BMP15 GDF9 on in vitro development follicles. This a controlled culture performed major tertiary university-affiliated medical center. Materials included ovarian tissue from 17 girls/women three aborted fetuses. There were no interventions. Histological...

To evaluate the effect of local injury to endometrium during spontaneous menstrual cycles before in vitro fertilization (IVF) treatment on implantation and pregnancy rates women with recurrent failure (RIF).In a prospective randomized controlled trial (RCT), total 36 patients, RIF undergoing IVF, were two groups. In 18 endometrial biopsies performed using pipelle curette days 9-12 21-24 cycle preceding IVF treatment. control cervical was performed.The rate (2.08% versus 11.11%; p = 0.1),...

Cumulus expansion and oocyte maturation are central processes in ovulation. Knowledge gained from rodent other mammalian models has revealed some of the molecular pathways associated with these processes. However, equivalent humans have not been thoroughly studied remain unidentified. Compact cumulus cells (CCs) germinal vesicle complexes (COCs) were obtained patients undergoing vitro (IVM) procedures. Expanded CCs metaphase 2 COC IVF/ICSI. Global transcriptome profiles samples using...

Objective: Human chorionic gonadotropin (hCG) is usually used at the end of controlled ovarian hyperstimulation (COH), as a surrogate LH surge, to induce final oocyte maturation and resumption meiosis. Recently, co-administration GnRH agonist hCG for – 40 34 h prior OPU, respectively (double trigger) was suggested improve IVF outcome in patient with genuine empty follicle syndrome. In present study, we aim evaluate whether double trigger might proportions metaphase-II (MII) oocytes patients...

Research questionWhat are the views and emotional reactions of patients towards suspension fertility treatment during COVID-19 pandemic, what factors affecting their psychological distress?DesignA cross-sectional study conducted in an academic centre. Online questionnaires were distributed between 18 April 2020 23 to whose cycle had been postponed or discontinued. The outcome measures included agreement with reproductive society guidelines postpone treatments; willingness resume treatments,...

To evaluate the clinical significance of pubic arch angle (PAA) measured by transperineal ultrasound during prolonged second stage labor.We evaluated prospectively 62 women ≥ 37 weeks gestation with failure to progress in labor. Transperineal (transverse plane) was used measure angle. Correlations fetomaternal characteristics, mode delivery and perinatal outcome were evaluated.The mean PAA 101.1° (± 13.1°; range, 80°-135°). We found a negative correlation maternal age. Patients an...

Recently, the co-administration of GnRH agonist and hCG for final oocyte maturation- 40 34 hours prior to OPU, respectively (double trigger) was suggested as treatment genuine empty follicle syndrome. In present study, we aim evaluate whether double trigger improves number oocytes retrieved in patients with low (<50%) per preovulatory follicles.In this proof concept cohort historical compared stimulation characteristics 8 IVF cycles, which include patients' previous attempt, triggered...

Hepatocyte transplantation within porous scaffolds (HT) is being explored as a treatment strategy for end-stage liver diseases and enzyme deficiencies. One of the main issues in this approach limited viability transplanted cells because vascularization scaffold site either too slow or insufficient. We now address by enhancing before cell via sustained delivery vascular endothelial growth factor (VEGF), examining lobes platform transplanting donor hepatocytes close proximity to host liver....

To investigate the mRNA expression of genes related to steroidogenesis and OHSS in granulosa cells (GCs) patients triggered with GnRH agonist compared hCG.Mural GCs were obtained at time oocyte retrieval gene was analyzed using quantitative real RT-PCR.Single center, case control study.24 women who treated or hCG for triggering ovulation.GC collection.The mural GCs.The fertilization rate similar two groups. The CYP19A1 (0.50 vs 1, arbitrary unit), CYP11A1 (0.6 vs. 1) 3 beta...

Follicular development and ovulation are major processes in the reproductive system. Understanding their complexity is important to female fertility treatments control of processes. Wnt signaling pathway components were shown be involved reproduction animal models. The secreted frizzled-related protein-4 (sFRP4), a potential modulator Wnt4 pathway, was induced by LH rodents expressed corpus lutea, but pattern its expression human ovaries remains unknown. We evaluated sFRP4 other sFRP family...

To describe the daily work practice under threat of defensive medicine among obstetricians and gynecologists.A prospective cross-sectional survey gynecologists working at tertiary medical centers in Israel.Among 117 who participated survey, representing 10% registered by Israel Medical Association, 113 (97%) felt that their is influenced concern about being sued for negligence not only genuine considerations. As a result, 102 (87%) physicians are more likely to offer cesarean section option,...

To evaluate the clinical significance of fetal head progression distance (HPD), measured by transperineal ultrasound, during prolonged second stage labor.In this prospective study, a single operator, who was blinded to results digital examination, assessed using ultrasound women at ≥ 37 weeks gestation with failure progress in labor. Patients had an empty urinary bladder and examination performed maternal pushing. HPD defined as length line perpendicular infrapubic that would connect it...

The ideal test for ovarian reserve should permit the identification of women who have no real chance pregnancy with IVF treatments consequent upon an extremely reduced reserve. aim current study was to evaluate rates in patients low AMH levels (0.2-1 ng/ml) and (<0.2 determine cumulative following consecutive treatments.We conducted historical cohort analysis at a tertiary medical center. Serum were measured initial clinic visit prior all treatment cycles 181 (769 cycles) level ≤1 ng/ml,...