Darren Roche

ORCID: 0000-0003-1010-4367
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Research Areas
  • Nonmelanoma Skin Cancer Studies
  • Cardiac, Anesthesia and Surgical Outcomes
  • COVID-19 and healthcare impacts
  • Cutaneous Melanoma Detection and Management
  • Immunodeficiency and Autoimmune Disorders
  • Genetic and rare skin diseases.
  • Autoimmune Bullous Skin Diseases
  • Pharmaceutical studies and practices
  • Health Systems, Economic Evaluations, Quality of Life
  • Skin Protection and Aging
  • Climate Change Communication and Perception
  • CAR-T cell therapy research
  • Blood Coagulation and Thrombosis Mechanisms
  • Heparin-Induced Thrombocytopenia and Thrombosis
  • Medicine and Dermatology Studies History
  • Dermatology and Skin Diseases
  • Acute Lymphoblastic Leukemia research
  • Vasculitis and related conditions
  • Ultrasound in Clinical Applications
  • Tumors and Oncological Cases
  • Biomedical Research and Pathophysiology
  • Biosimilars and Bioanalytical Methods
  • Ocular Surface and Contact Lens
  • Respiratory Support and Mechanisms
  • Cutaneous lymphoproliferative disorders research

University of Utah
2024

South Infirmary Victoria University Hospital
2021-2023

Sligo University Hospital
2023

Tallaght University Hospital
2019-2022

Institut de Virologie
2021

Cork University Hospital
1998-2021

University Hospital Galway
2021

Mater Private Hospital
2021

National University of Ireland
1998

Abstract Background Management options for the treatment of melanoma have expanded in recent years. In an era promising, but expensive novel pharmacological treatments, robust stage-specific melanoma-related cost estimates are necessary to support budgetary planning, evaluation cost-effectiveness and contribute investment case prevention. Methods A detailed decision model, describing care pathway (by disease stage) from diagnosis, through follow-up was developed over a 5-year time frame...

10.1093/pubmed/fdac154 article EN cc-by-nc Journal of Public Health 2023-05-11

10.1016/0022-3468(94)90237-2 article EN Journal of Pediatric Surgery 1994-12-01

Endurance events are popular worldwide and have many health benefits. However, runners Para athletes may sustain musculoskeletal injuries or experience other consequences from endurance events. The American Medical Society for Sports Medicine (AMSSM) Runner Health Consortium aimed to generate consensus-based survey items use in prospective research identify risk factors training competing study design employed a modified Delphi approach, with panel comprising 28 experts, including healthcare...

10.1136/bjsports-2023-108059 article EN cc-by-nc British Journal of Sports Medicine 2024-11-01

Background The burden of illness associated with atopic dermatitis (AD) is significant and multidimensional, especially in those moderate to severe disease. Objective Our objective was evaluate the disease patients AD relation psychological distress, sleep disturbance, alcohol misuse. Methods Patients AD, attending 2 tertiary referral centers Dublin, Ireland, were recruited. A series validated questionnaires used including Patient-Oriented Eczema Measure, Dermatology Life Quality Index...

10.1097/der.0000000000000687 article EN Dermatitis 2020-12-17

A 28-year-old farmer with class IV lupus nephritis presented a two-week history of right shin lesion. The lesion was purple in color, fungating, and indurated focus deep ulceration at the inferior pole punctate, bleeding from its surface. Three months earlier, he started on induction immunosuppression for relapse his nephritis. Since diagnosis nephritis, nine years previously, had six flares disease been treated different time points cyclophosphamide, rituximab, high-dose corticosteroids,...

10.7759/cureus.19512 article EN Cureus 2021-11-12

Little is known about biological outcomes for severe psoriasis in trisomy 21 (T21). Our aim was to review of patients with T21 and treated biologic or Janus kinase inhibitors (JAKi). Information on demographics, co-morbidities, therapeutic responses retrospectively collated. Twenty-one were identified (mean age 24.7 years). Ninety percent (18/20) TNFα inhibitor trials failed. Almost two-thirds (7/11) achieved an adequate response ustekinumab. All three tofacitinib following at least...

10.1111/1346-8138.16851 article EN cc-by The Journal of Dermatology 2023-06-08

10.1111/ced.14576 article DE Clinical and Experimental Dermatology 2021-03-05

We report a case of symmetrical drug-related intertriginous and flexural exanthema following antiretroviral postexposure prophylactic medications, tenofovir emtricitabine, commencement which preceded the onset rash. Tenofovir emtricitabine are both nucleoside reverse transcriptase inhibitor commonly used to prevent development AIDS.

10.1111/ced.15131 article EN cc-by Clinical and Experimental Dermatology 2022-03-17

Abstract Trisomy 21 (T21) is strongly associated with autoimmune disease, including psoriasis. Little known about biologic outcomes for severe psoriasis in T21. T21-associated immune dysregulation has implications efficacy, safety and drug survival of medications. The aim was to review the patients T21 treated agents or Janus kinase inhibitors (JAKi) our region. Patients were identified via databases regional dermatology departments province Munster, Ireland. Information on demographics,...

10.1093/bjd/ljad113.111 article EN British Journal of Dermatology 2023-06-01

<h3>Background</h3> Acute haemorrhagic oedema of infancy (AHOI) or Finkelstein/Seidlmayer disease, is an uncommon leukocytoclastic small-vessel vasculitis typically occurring between the ages 6 months and 2 years. Despite its alarming presentation, it benign often has a self-limiting course. <h3>Case report</h3> A 4-year-old girl presented to Emergency Department with 2-day history diffuse spreading erythematous rash, joint pain swelling. She was unwell for previous weeks cough upper...

10.1136/archdischild-2019-epa.472 article EN Abstracts 2019-06-01

10.1007/bf02937234 article EN Irish Journal of Medical Science (1971 -) 1998-04-01

Click here for the corresponding questions to this CME article.

10.1111/ced.14560 article EN Clinical and Experimental Dermatology 2021-03-05

Rapidly involuting congenital haemangiomas (RICH) are typically located in the head/neck or lower extremities and solitary. They vary size up to greater than 10 cm. Several clinical morphologies described. Typically, involution begins a few days weeks after birth is usually complete before 14 months (1).The process of produces often areas redundant skin with atrophy dermal subcutaneous tissues. Findings can also include textural color abnormalities, telangiectasia, alopecia, superficial...

10.26326/2281-9649.31.2.2245 article EN European Journal of Pediatric Dermatology/PD. European journal of pediatric dermatology 2021-04-18
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