A5100403680- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Cancer-related gene regulation
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
Baylor College of Medicine
2022-2023
The First People's Hospital of Changzhou
2020
Soochow University
2020
Stanford University
2017
Palo Alto University
2017
Characterization of the epigenome is a primary interest for children's environmental health researchers studying influences on human populations, particularly those role pregnancy and early-life exposures later-in-life outcomes.Our objective was to consider state science in epigenetics research focus DNA methylation collective observations many studies being conducted within Children's Environmental Health Disease Prevention Research Centers, as they relate Developmental Origins (DOHaD)...
Abstract Background Genetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example at methylation quantitative trait loci (mQTL). We present the first large-scale assessment of mQTL human genomic regions selected interindividual variation in CpG methylation, which we call correlated systemic (CoRSIVs). These be assayed blood DNA and do not reflect cellular composition. Results use target-capture bisulfite sequencing to assess 4086 CoRSIVs multiple tissues from...
DNA methylation is thought to be an important determinant of human phenotypic variation, but its inherent cell type specificity has impeded progress on this question. At exceptional genomic regions, interindividual variation in occurs systemically. Like genetic variants, systemic epigenetic variants are stable, can influence phenotype, and assessed any easily biopsiable sample. We describe unbiased screen for regions at which not tissue-specific.
Abstract Genetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example by affecting DNA methylation at CpG dinucleotides (methylation quantitative trait loci – mQTL). Here, we present the first large-scale assessment of mQTL human genomic regions selected interindividual variation in (correlated systemic CoRSIVs). We used target-capture bisulfite sequencing to assess 4,086 CoRSIVs multiple tissues from 188 donors NIH Genotype-Tissue Expression (GTEx) program...