A5051765780- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- RNA regulation and disease
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- Viral Infections and Immunology Research
- Diabetes and associated disorders
- Psoriasis: Treatment and Pathogenesis
- HIV, Drug Use, Sexual Risk
- Carbohydrate Chemistry and Synthesis
- Lysosomal Storage Disorders Research
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Autoimmune Bullous Skin Diseases
- interferon and immune responses
- Opioid Use Disorder Treatment
- Glycogen Storage Diseases and Myoclonus
- HIV/AIDS Research and Interventions
University of Washington
2016-2024
University of Salzburg
2016-2020
University of California, San Francisco
2013-2020
Regulatory T cells (Tregs), which are characterized by expression of the transcription factor Foxp3, a dynamic and heterogeneous population that control immune responses prevent autoimmunity. We recently identified subset Tregs in murine skin with properties typical memory defined this as (mTregs). Due to importance these regulating tissue inflammation mice, we analyzed cell humans found almost all normal had an activated phenotype. Compared mTregs peripheral blood, cutaneous unique surface...
Thymic Foxp3-expressing regulatory T cells are activated by peripheral self-antigen to increase their suppressive function, and a fraction of these survive as memory (mTregs). mTregs persist in nonlymphoid tissue after cessation Ag expression have enhanced capacity suppress tissue-specific autoimmunity. In this study, we show that murine express specific effector cell markers localize preferentially hair follicles skin. Memory Tregs high levels both IL-2Rα IL-7Rα. Using genetic-deletion...
Immune homeostasis in peripheral tissues is achieved by maintaining a balance between pathogenic effector T cells (Teffs) and protective Foxp3(+) regulatory (Tregs). Using mouse model of an inducible tissue Ag, we demonstrate that Ag persistence major determinant the relative frequencies Teffs Tregs. Encounter transferred naive CD4(+) with transiently expressed leads to generation cytokine-producing Persistent expression mimic self-antigen, functional inactivation loss preservation Tregs...
Tumor necrosis factor α (TNF) inhibitor-induced psoriasiform eruption is well recognized in adults, but few reports document this paradoxical effect children.
Abstract Migratory dendritic cell (DC) subsets deliver tissue Ags to draining lymph nodes (DLNs) either initiate or inhibit T cell–mediated immune responses. The signals mediating DC migration in response self-antigen are largely unknown. Using a mouse model of inducible skin-specific expression, we demonstrate that CD103+ dermal DCs (DDCs) rapidly migrate from skin DLN (SDLNs) within the first 48 h after Ag expression. This window time was characterized by preferential activation...
Adult-onset Niemann–Pick disease type C (NPC) is an infrequent presentation of a rare neurovisceral lysosomal lipid storage disorder caused by autosomal recessive mutations in NPC1 (∼95%) or NPC2 (∼5%). Our patient was diagnosed at age 33 when he presented with 10-yr history difficulties judgment, concentration, speech, and coordination. A transient neonatal jaundice splenomegaly bone marrow biopsy suggesting pointed to NPC; biochemical (“variant” level cholesterol esterification)...
Summary Mutations in ADAR , the gene that encodes ADAR1 RNA deaminase, cause numerous human diseases, including Aicardi-Goutières Syndrome (AGS). is an essential negative regulator of sensor MDA5, and loss function triggers inappropriate activation MDA5 by self-RNAs. However, mechanisms MDA5-dependent disease pathogenesis vivo remain unknown. Here, we introduce a knockin mouse models most common AGS mutation humans. These Adar -mutant mice develop lethal requires RIG-I-like receptor LGP2,...
In Kenya, overdose remains a major public health concern with approximately 40% of persons who inject drugs (PWID) reporting personal overdoses. PWID living HIV (PWID-LH) are particularly vulnerable to experiencing fatal and non-fatal overdoses because the surrounding physical, social, economic, political environments, which not fully understood in Kenya. Through qualitative inquiry, this study characterizes Kenya's risk environment. Participants were purposively recruited from larger cohort...
Immune homeostasis in peripheral tissues is, to a large degree, maintained by the differentiation and action of regulatory T cells (Treg) specific for tissue Ags. Using novel mouse model, we have studied naive CD4+ into Foxp3+ Treg response cutaneous Ag (OVA). We found that expression OVA resulted fatal autoimmunity prevention generation. Inhibiting mTOR activity with rapamycin rescued generation cells. When varied level modulate TCR signaling, low concentrations promoted cells, whereas high...