A5039662545- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Ocular Diseases and Behçet’s Syndrome
- RNA modifications and cancer
- Retinal and Optic Conditions
- Facial Nerve Paralysis Treatment and Research
- Single-cell and spatial transcriptomics
The Netherlands Cancer Institute
2019-2025
Dutch Cancer Society
2025
Oncode Institute
2020-2024
Macrophage subsets are dynamically altered during glioma response to radiotherapy, and their targeting delays tumor recurrence in preclinical trials.
Glioblastomas are aggressive primary brain tumors with an inherent resistance to T cell-centric immunotherapy due their low mutational burden and immunosuppressive tumor microenvironment. Here we report that fractionated radiotherapy of preclinical glioblastoma models induce a tenfold increase in cell content. Orthogonally, spatial imaging mass cytometry shows enrichment human recurrent compared matched glioblastoma. In glioblastoma-bearing mice, α-PD-1 treatment applied at the peak...
Abstract Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory immunosuppressive roles have been assigned course of tumorigenesis. Yet several aspects underlying their dynamic alterations hepatocellular carcinoma (HCC) progression remain elusive, including impact distinct genetic mutations shaping a cancer-permissive tumor microenvironment (TME). Here, newly generated, clinically-relevant somatic female HCC mouse models, we identify...
Abstract The rising incidence and increasing mortality of hepatocellular carcinoma (HCC), combined with its high tumor heterogeneity, lack druggable targets, tendency to develop resistance chemotherapeutics, make the development better models for this cancer an urgent challenge. To mimic diversity within HCC genetic landscape, versatile somatic murine have recently been developed using hydrodynamic tail vein injection (HDTVi) system. These represent novel in vivo tools interrogate phenotype...
Abstract Differentiation of antigen-activated B cells into pro-proliferative germinal center (GC) depends on the activity transcription factor MYC and epigenetic writers DOT1L EZH2. GCB-like Diffuse Large Cell Lymphomas (GCB-DLBCLs) arise from GC closely resemble their cell origin. Given dependency EZH2, we investigated role these regulators in GCB-DLBCL lines observed that GCB-DLBCLs synergistically depend combined Mechanistically, inhibiting both enzymes led to enhanced derepression PRC2...