A5031272281- Workplace Health and Well-being
- PI3K/AKT/mTOR signaling in cancer
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Occupational Health and Safety Research
- Radiomics and Machine Learning in Medical Imaging
- PARP inhibition in cancer therapy
- Employment and Welfare Studies
- Colorectal Cancer Surgical Treatments
- Pancreatic function and diabetes
- Protein Tyrosine Phosphatases
- Retirement, Disability, and Employment
- DNA Repair Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Protein Kinase Regulation and GTPase Signaling
- Advanced Breast Cancer Therapies
- Bioinformatics and Genomic Networks
- Cancer Risks and Factors
- Health, psychology, and well-being
- Peptidase Inhibition and Analysis
Vrije Universiteit Amsterdam
2019-2025
Amsterdam University Medical Centers
2019-2025
Oncode Institute
2018-2024
The Netherlands Cancer Institute
2014-2024
Creative Commons
2022
Instituut Gak
2022
Karolinska Institutet
2021
Public Health Service of Amsterdam
2020
Amsterdam Public Health
2013-2015
University Medical Center
2014
The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found human liver was dependent extracellular glutamine. However, targeting addiction using the glutaminase inhibitor CB-839 monotherapy had very limited anticancer effect, even against most addicted cells. Using chemical library, identified V-9302, novel transporter ASCT2, sensitizing (GD) to treatment. Mechanically, combination and...
Oncogenic fusion genes that involve kinases have proven to be effective targets for therapy in a wide range of cancers. Unfortunately, the diagnostic approaches required identify these events are struggling keep pace with diverse array genetic alterations occur cancer. Diagnostic screening solid tumours is particularly challenging, as many low frequency. To overcome limitations, we developed capture enrichment strategy enable high-throughput transcript sequencing human kinome. This approach...
PURPOSE: To assess the depth of infiltration rectal cancer with transrectal ultrasound (US) (TRUS) and analyze interpretation errors. MATERIALS AND METHODS: Fifty-five consecutive patients who underwent TRUS were prospectively studied. The effect different patient inclusion criteria US was evaluated retrospectively. RESULTS: Extensive overstaging T2 tumors, partially caused by inflammatory (desmoplastic) reaction or retraction muscularis propria, resulted in a specificity only 24% for...
Triple negative (TN) breast cancers make up some 15% of all cancers. Approximately 10–15% are mutant for the tumor suppressor, BRCA1. BRCA1 is required homologous recombination‐mediated DNA repair and deficiency results in genomic instability. BRCA1‐mutated tumors have a specific pattern copy number aberrations that can be used to classify as BRCA1‐like or non‐BRCA1‐like. mutation, promoter methylation, status genome‐wide expression data was determined 112 TN cancer samples with long‐term...
Patients with BRCA1-like tumors correlate improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed distinguish between and non-BRCA1-like tumors. We hypothesized that these may also be more sensitive PARP inhibitors than standard treatments. diagnostic expression signature (BRCA1ness) using a centroid model 128 triple-negative breast cancer samples from the EU FP7 RATHER project. This BRCA1ness then tested in HER2-negative patients (n =...
The Kirsten rat sarcoma viral oncogene homologue KRAS is among the most commonly mutated oncogenes in human cancers, thus representing an attractive target for precision oncology. approval clinical use of first selective inhibitors G12C mutant therefore holds great promise cancer treatment. However, despite initial encouraging results, overall survival benefit that patients experience following treatment with these has been disappointing to date, pointing toward need develop more powerful...
Over 90% of pancreatic cancers present mutations in KRAS, one the most common oncogenic drivers overall. Currently, KRAS mutant isoforms cannot be targeted directly. Moreover, targeting single RAS downstream effectors induces adaptive resistance mechanisms. We report here on combined inhibition SHP2, upstream using allosteric inhibitor RMC-4550 and ERK, LY3214996. This combination shows synergistic anti-cancer activity vitro, superior disruption MAPK pathway, increased apoptosis induction...
Supporting employees with chronic conditions can prevent work-related problems and facilitate sustainable employment. Various stakeholders are involved in providing support to these employees. Understanding their current practices experienced barriers is useful for the development of an organizational-level intervention improve this support. The aim study was explore occupational physicians organizational representatives, identifying both opportunities improvement.Two focus groups sixteen...
Abstract Background Working with a chronic condition can be challenging. Providing support to workers help them stay at work and prevent work-related problems. Workers who successfully provide valuable input for the development of effective supportive interventions exit from facilitate sustainable employment. The aim this study is explore lived experiences identify existing barriers, facilitators possible needs staying work. Methods Four focus groups were conducted between August December...
Liver cancer is the fourth most common cause of cancer-related death worldwide, with hepatocellular carcinoma (HCC) being main primary malignancy affecting liver. Unfortunately, there are still limited therapeutic options for HCC, and even latest advances have only increased overall survival modestly. Thus, new treatment strategies rational drug combinations urgently needed. Reactivation receptor tyrosine kinases (RTK) has been described as a mechanism intrinsic resistance to targeted...
Previous studies among people with work disabilities (WD) showed that during the COVID-19 pandemic they were at risk for negative outcomes on participation and health. These focused people's own accounts of their difficulties to did not include policy practice perspective. The aim present study was explore perspective what can be learned from impact crisis, is needed enhance WD, in times crisis beyond. We used a multi-stakeholder qualitative approach. Between March 2021 September 2022,...
Preoperative staging of lymph nodes in patients with rectal cancer is essential for selecting the most appropriate therapy. To determine discriminating value all ultrasound parameters described literature, authors obtained high-frequency sonograms 43 21 resected specimens, thereby simulating vivo situation. Univariate analysis revealed that inhomogeneity (P less than .0005), short axis diameter .005), and hilar reflection .01) were helpful differentiating between metastatically involved...
Workers with a low socioeconomic position (SEP) have higher risk for health problems and premature dropout from the workforce. Unfavorable working conditions unhealthy behaviors are more prevalent among this group of workers. The Participatory Approach (PA), is an evidence-based method to identify solve at workplace related issues worker. Health workers SEP usually caused by interplay in outside workplace. To on multiple life domains we aim adapt approach broader perspective.An Intervention...
Working while having a chronic condition can be challenging. Self-control at work could play an important role for workers with in sustainable participation. The aim of this qualitative synthesis is to profile elements self-control and gain insight its exertion, from the perspective condition. Four databases were systematically searched relevant articles January 2007 October 2017 (PubMed, PsycINFO, Embase, CINAHL). Search terms related work, seven prevalent conditions, subjective needs...
Exclusion of focal infiltrating malignancy in colorectal villous adenoma is a prerequisite when nonsurgical treatment considered. In study 81 patients with endoscopically identified screened for transrectal ultrasonography (US), 15 were excluded because incomplete follow-up. Twelve carcinomas present, confirmed either histopathologic examination after surgical resection (n = 9) or biopsies during laser 3). Nine them detected US on the basis disruption anatomic wall layers (sensitivity, 75%)....
<b><i>Aims:</i></b> Currently, many patients with maturity onset diabetes of the young (MODY) are undiagnosed or misdiagnosed type 1 2 diabetes. This study aims to assess professional experts' views on factors which may influence current practice genetic testing for MODY and explore next steps toward best practice. <b><i>Methods:</i></b> Twelve semistructured interviews were conducted experts. These experts included physicians potential actual...
Abstract Aims Genetic testing for maturity‐onset diabetes of the young ( MODY ) facilitates a correct diagnosis, enabling treatment optimization and allowing monitoring asymptomatic family members. To date, majority people with remain undiagnosed. identify patients' needs areas improving care, this study explores experiences patients members who have been genetically tested . Methods Fourteen semi‐structured interviews parents patients, symptomatic were conducted. Atlas.ti was used thematic...
Abstract Motivation Signal-transduction networks are often aberrated in cancer cells, and new anti-cancer drugs that specifically target oncogenes involved signaling show great clinical promise. However, the effectiveness of such targeted treatments is hampered by innate or acquired resistance due to feedbacks, crosstalks network adaptations response drug treatment. A quantitative understanding these how they differ between cells with different oncogenic mutations sensitive resistant can...