A5012378866- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Monoclonal and Polyclonal Antibodies Research
- Enzyme Structure and Function
- RNA modifications and cancer
- Plant Gene Expression Analysis
- Plant-Microbe Interactions and Immunity
- SARS-CoV-2 detection and testing
- Plant biochemistry and biosynthesis
- Genetics, Bioinformatics, and Biomedical Research
- Influenza Virus Research Studies
- Metal complexes synthesis and properties
- Scientific Computing and Data Management
- ATP Synthase and ATPases Research
- Cancer Genomics and Diagnostics
- Soil and Unsaturated Flow
- Biochemical and Molecular Research
- Radioactive element chemistry and processing
- Cancer-related gene regulation
- Chemical Synthesis and Analysis
- Endoplasmic Reticulum Stress and Disease
- Water and Wastewater Treatment
University of California, San Diego
2022-2025
Indian Institute of Technology Madras
2016-2021
Defence Research and Development Establishment
2010-2021
Indian Institute of Technology Guwahati
2008-2016
Abstract Protein–nucleic acid interactions are involved in various biological processes such as gene expression, replication, transcription, translation and packaging. The binding affinities of protein–DNA protein–RNA complexes important for elucidating the mechanism protein–nucleic recognition. Although experimental data on affinity reported abundantly literature, no well-curated database is currently available affinity. We have developed a database, ProNAB, which contains more than 20 000...
Intrinsically disordered regions (IDRs) and protein (IDPs) are highly flexible owing to their lack of well-defined structures. A subset such proteins interacts with various substrates; including RNA; frequently adopting regular structures in the final complex. In this work; we have analysed a dataset protein–RNA complexes undergoing disorder-to-order transition (DOT) upon binding. We found that DOT generally small size (less than 3 residues) for RNA binding proteins. Like structured...
Abstract The urgent need for a treatment of COVID-19 has left researchers with limited choice either developing an effective vaccine or identifying approved/investigational drugs developed other medical conditions potential repurposing, thus bypassing long clinical trials. In this work, we compared the sequences experimentally verified SARS-CoV-2 neutralizing antibodies and sequentially/structurally similar commercialized therapeutic monoclonal antibodies. We have identified three...
Lipoxygenase-1 (LOX-1) protein provides defense against pests and pathogens its presence have been positively correlated with plant resistance pathogens. Linoleate is a known substrate of lipoxygenase it induces necrosis leading to the accumulation isoflavonoid phytoalexins in leaves. Therefore, interest study structural features LOX-1 from Finger millet. However, structure ofLOX-1 millet not yet known. A homology model described. Domain architecture suggested two domains namely PLAT...
Abstract Protein‐DNA interactions are involved in various fundamental biological processes such as replication, transcription, DNA repair, and gene regulation. To understand the interaction protein‐DNA complexes, integrative study of binding stabilizing residues is important. In present study, we have identified key that play a dual role both stability from nonredundant dataset 319 complexes. We observed very less number complexes (29%) only about 4% stabilizing/binding residues....
Abstract The 2019‐novel coronavirus also known as severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) is a common threat to animals and humans, responsible for the human SARS pandemic in 2019 2021. infection of SARS‐CoV‐2 humans involves viral surface glycoprotein named spike proteins, which bind angiotensin‐converting enzyme (ACE2) proteins. Particularly, receptor binding domains (RBDs) mediate interaction contain several disordered regions, help binding. Investigations on...
<ns4:p>Regional Student Groups (RSGs) of the International Society for Computational Biology Council (ISCB-SC) have been instrumental to connect computational biologists globally and create more awareness about bioinformatics education. This article highlights initiatives carried out by RSGs both nationally internationally strengthen present future community. Moreover, we discuss directions organization will take challenges advance further in ISCB-SC main mission: “Nurture new generation...
About one-third of the existing proteins require metal ions as cofactors for their catalytic activities and structural complexities. While many them bind only to a specific metal, others multiple (different) ions. However, exact mechanism preference has not been deduced clarity. In this study, we used molecular dynamics (MD) simulations investigate whether cognate (bound structure) can be replaced with other similar We have chosen seven different (phospholipase A2, sucrose phosphatase,...
Protein-RNA complexes play important roles in various biological processes. The functions of protein-RNA are dictated by their interactions, binding, stability, and affinity. In this work, we have identified the key residues (KRs), which involved both stability binding. We found that 42 percent considered proteins share common binding stabilizing residues, whereas these distinct 58 proteins. Overall, 5 3 serve as residues. These enriched with combination polar, charged, aliphatic, aromatic...
COVID-19 has emerged as global pandemic with largest damage to the public health, economy and human psyche.The genome sequence data obtained during ongoing are valuable understand virus evolutionary patterns spread across globe. Increased availability of information circulating SARS-CoV-2 strains in India will enable scientific community emergence new variants their impact on health. The first case was detected Chambal region Madhya Pradesh state mid March 2020 followed by multiple...
Simulation of a virus transport process in groundwater aquifer is necessary for predicting the movement viruses an aquifer. It also implementing remedial measures to inactivate present groundwater. For simulating aquifer, parameters responsible have be estimated. In case saturated porous media, are linear distribution coefficient, hydrodynamic dispersion and inactivation coefficient aqueous sorbed viruses. These can estimated using inverse optimization procedure that minimizes error function...
Abstract COVID 19 has emerged as global pandemic with largest damage to the economy and human psyche. The genomic signature deciphered during ongoing period is valuable understand virus evolutionary patterns spread across globe. Increased availability of genome information circulating strain in our country will enable generate selective details virulent non markers prophylaxis therapeutic interventions. first case SARS CoV-2 was detected Chambal region Madhya Pradesh state mid March 2020...
Intrinsically disordered regions (IDRs) in proteins are characterized by their flexibilities and low complexity regions, which lack unique 3 D structures solution. IDRs play a significant role signaling, regulation, binding multiple partners, including DNA, RNA, proteins. Although various experiments have shown the of with detailed computational analysis is required to understand recognition mechanism. In this work, we performed molecular dynamics simulations 10 protein-RNA complexes...
Abstract Rhomboid proteases are ubiquitous intramembrane serine that can cleave transmembrane substrates within lipid bilayers. They exhibit many and diverse functions, such as but not limited to, growth factor signaling, immune inflammatory response, protein quality control, parasitic invasion. Human rhomboid protease RHBDL4 has been demonstrated to play a critical role in removing misfolded proteins from the Endoplasmic Reticulum is implicated severe diseases various cancers Alzheimer’s...