A5071688433- Coordination Chemistry and Organometallics
- Cognitive Abilities and Testing
- Functional Brain Connectivity Studies
- Phosphodiesterase function and regulation
- Organometallic Complex Synthesis and Catalysis
- Neural dynamics and brain function
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and characterization of novel inorganic/organometallic compounds
- Asymmetric Synthesis and Catalysis
- Organophosphorus compounds synthesis
- Asymmetric Hydrogenation and Catalysis
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- X-ray Diffraction in Crystallography
- Molecular spectroscopy and chirality
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Effects and risks of endocrine disrupting chemicals
- Cognitive Functions and Memory
- Carcinogens and Genotoxicity Assessment
- Catalysis and Oxidation Reactions
- Mental Health Research Topics
- Catalytic C–H Functionalization Methods
- Enzyme function and inhibition
- Identity, Memory, and Therapy
University of Stuttgart
2024
University of Illinois Urbana-Champaign
1995-2020
GlaxoSmithKline (United Kingdom)
2005-2018
Urbana University
1997-2008
University of Cambridge
1998-2005
Plasma Technology (United States)
1999
Friedrich-Alexander-Universität Erlangen-Nürnberg
1993
Merseburg University of Applied Sciences
1980
Recent papers report transition metal-free couplings of haloarenes to arenes form biaryls, triggered by alkali metal tert-butoxides in the presence various additives. These reactions proceed through radical intermediates, but understanding origin radicals has been problematic. Electron transfer from a complex formed potassium tert-butoxide with additives, such as phenanthroline, suggested initiate process. However, our computational results encouraged us search for alternatives. We that...
Brain training programs have proliferated in recent years, with claims that video games or computer-based tasks can broadly enhance cognitive function. However, benefits are commonly seen only trained tasks. Assessing generalized improvement and practicality of laboratory exercises complicates interpretation application findings. In this study, we addressed these issues by using active control groups, more closely resemble real-world demands multiple tests to determine transfer training. We...
The 2014 CSAR Benchmark Exercise was the last community-wide exercise that conducted by group at University of Michigan, Ann Arbor. For this event, GlaxoSmithKline (GSK) donated unpublished crystal structures and affinity data from in-house projects. Three targets were used: tRNA (m1G37) methyltransferase (TrmD), Spleen Tyrosine Kinase (SYK), Factor Xa (FXa). A particularly strong feature GSK is its large size, which lends greater statistical significance to comparisons between different...
Although some studies have shown that cognitive training can produce improvements to untrained domains (far transfer), many others fail show these effects, especially when it comes improving fluid intelligence. The current study was designed overcome several limitations of previous by incorporating expectancy assessments, an active control group, and "Mind Frontiers," a video game-based mobile program comprised six adaptive, cognitively demanding tasks been found lead increased scores in...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzaborines: an ab initio studyMichael Kranz and Timothy ClarkCite this: J. Org. Chem. 1992, 57, 20, 5492–5500Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/jo00046a035https://doi.org/10.1021/jo00046a035research-articleACS PublicationsRequest reuse permissionsArticle Views473Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRotational barriers of 1,1'-binaphthyls: a computational studyMichael Kranz, Timothy Clark, and Paul v. R. SchleyerCite this: J. Org. Chem. 1993, 58, 12, 3317–3325Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jo00064a018https://doi.org/10.1021/jo00064a018research-articleACS PublicationsRequest reuse permissionsArticle...
The structure of the 1,4-azaborinine ring in title compound, a representative novel class potentially aromatic compounds that are isoelectronic with arenes, confirms conclusions earlier ab initio calculations cyclic conjugation 1,4-azaborinines is interrupted by boron atom.
The enantioselective addition of organolithium reagents to N-anisyl aldimines promoted by chiral bisoxazolines and (-)-sparteine as external ligands is described. This reaction proceeds readily with a wide range aldimine substrates (aliphatic, aromatic, olefinic) nucleophiles (Me, n-Bu, Ph, vinyl) in excellent yields (81-99%) high enantioselectivities (up 95.5:4.5 er). can be used substoichiometric amounts albeit slightly attenuated enantioselectivities. A systematic evaluation the...
Understanding the neural and metabolic correlates of fluid intelligence not only aids scientists in characterizing cognitive processes involved intelligence, but it also offers insight into intervention methods to improve intelligence. Here we use magnetic resonance spectroscopic imaging (MRSI) measure N-acetyl aspartate (NAA), a biochemical marker energy production efficiency. We principal components analysis (PCA) examine how distribution NAA frontal parietal lobes relates find that left...
A series of potent phthalazinone-based human H(1) and H(3) bivalent histamine receptor antagonists, suitable for intranasal administration the potential treatment allergic rhinitis, were identified. Blockade receptors is thought to improve efficacy on nasal congestion, a symptom rhinitis that currently not treated by current antihistamines. Two analogues (56a 56b) had slightly lower potency (pA(2) 9.1 8.9, respectively, vs 9.7 clinical gold-standard azelastine, (pK(i) 9.6 9.5, 6.8...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn ab Initio Study of the P-C Bond Rotation in Phosphorus-Stabilized Carbanions: The Phosphoryl versus Thiophosphoryl GroupMichael Kranz and Scott E. DenmarkCite this: J. Org. Chem. 1995, 60, 18, 5867–5877Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/jo00123a024https://doi.org/10.1021/jo00123a024research-articleACS PublicationsRequest reuse...
The potential energy surfaces for the P−C bond rotation in 2-oxo- and 2-thioxo-2-methyl-1,3,2-diazaphosphorinane -1,3,2-diazaphospholidine anions have been investigated at MP4(SDQ)/6-31+G*//HF/6-31+G* + ZPE. Four stationary points found six-membered ring species. lowest structures exhibit a completely or nearly planar carbanion with its substituents parallel to PX axis (X = O, S). transition state (TS) strongly pyramidalized which lone pair (LP) is approximately perpendicular bond. Isodesmic...
Abstract The 6U CubeSat EIVE was developed for the verification of an E-band link from space to ground. Establishing such a presents challenging requirements development attitude control system CubeSat. To verify functionality its components, both sensors and actuators, number tests were conducted prior launch. These ranged simple performance accompanied by calibration campaigns. Qualification algorithms proved be challenge, as fitting simulator setup not available. Therefore, limited...
Abstract The recently isolated broad‐spectrum antiparasitic apicidin ( 1 ) is one of the few naturally occurring cyclic tetrapeptides (CTP). Depending on solvent, backbone exhibits two γ‐turns (in CH 2 Cl or a β‐turn DMSO), differing solely in rotation plane amide bonds. In X‐ray crystal structure, peptidic COs and NHs are opposite sides plane, giving rise to infinite stacks cyclotetrapeptides connected by three intermolecular hydrogen bonds between backbones. Conformational searches (Amber...