A5080296619- Inflammatory Bowel Disease
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Vaccine Coverage and Hesitancy
- Erythropoietin and Anemia Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Development and Preterm Care
- Thyroid Cancer Diagnosis and Treatment
- Bone health and treatments
- Infectious Diseases and Tuberculosis
- Liver Diseases and Immunity
- Intestinal Malrotation and Obstruction Disorders
- Neonatal Respiratory Health Research
The Royal Wolverhampton NHS Trust
2020-2025
Florida International University
2025
Mayo Clinic in Arizona
2015-2025
WinnMed
2024
All India Institute of Medical Sciences Bhubaneswar
2024
University Hospitals Birmingham NHS Foundation Trust
2023
Wolverhampton Hospital
2020-2023
New Cross Hospital
2005-2023
Georgia Institute of Technology
2018-2023
The Wallace H. Coulter Department of Biomedical Engineering
2020-2023
Historical outcomes in anaplastic thyroid cancer (ATC) have been dismal. To determine whether an initial intensive multimodal therapy (MMT) is associated with improved ATC survival. MMT was offered to all patients newly diagnosed treated at the Mayo Clinic from 2003 through 2015; vs care palliative intent (PI) individualized considering clinical status and patient preferences. Outcomes were retrospectively analyzed by American Joint Committee on Cancer stage treatments compared cohort data...
Background The type 2 iodothyronine deiodinase (D2) converts the pro-hormone thyroxine into T3 within target tissues. D2 is essential for a full thermogenic response of brown adipose tissue (BAT), and mice with disrupted Dio2 gene (D2KO) have an impaired to cold. BAT also activated by overfeeding. Methodology/Principal Findings After 6-weeks HFD feeding D2KO gained 5.6% more body weight had 28% tissue. Oxygen consumption (V02) was not different between genotypes, but increased respiratory...
Objective A key challenge towards a successful COVID-19 vaccine uptake is hesitancy. We examine and provide novel insights on the drivers barriers uptake. Design This study involved an anonymous cross-sectional online survey circulated across UK in September 2020. The was designed to include several sections collect demographic data responses (1) extent of agreement regarding various statements about vaccinations, (2) previous vaccination habits (eg, if they had previously declined...
This study aims to determine differences in the on- and off-tumor microbiota between patients with right- left-sided colorectal cancer. Microbiome profiling of tumor tumor-adjacent biopsies from right-sided (n = 17) 7) adenocarcinoma was performed using 16S ribosomal RNA sequencing. Off-tumor alpha beta diversity were significantly different cancer patients. However, no on-tumor observed locations. Comparing showed right colon be enriched species Lachnoclostridium, Selenomonas, Ruminococcus...
An estimated 2.5-3 million individuals (0.4%) in Europe are affected by inflammatory bowel disease (IBD). Whilst incidence rates for IBD stabilising across Europe, the prevalence is rising and subsequently resulting a significant cost to healthcare system of an 4.6-5.6 billion euros per year. Hospitalisation surgical resection generally on downward trend, which contrary novel medication. This signifies large part burden. Despite publicly funded systems most European countries, there still...
We share a case of 38-year-old male with history hypertension and metabolic dysfunction-associated steatotic liver disease (MASLD) who was admitted for septic arthritis the left sacroiliac joint, pyomyositis, associated methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia. The patient presented hip pain, fever, tachycardia, leukocytosis. A physical exam revealed lateral tenderness limited range motion. Lumbar spine magnetic resonance imaging (MRI) arthritis, inflammation multiple...
Abstract Background Tofacitinib, filgotinib and upadacitinib are JAK inhibitors (JAKi) that licensed for treatment in moderate to severe ulcerative colitis (UC). Whilst these drugs have demonstrated efficacy against placebo, there is no head-to-head data. This study aims compare the clinical between drugs. Methods a multi-centred, retrospective cohort with data collected from January 2018 June 2024. Patients UC were recruited on their first JAKi, irrespective of previous advanced therapies....
Objective Participation in clinical research confers tangible benefits for patients and healthcare organisations. Achieving adequate representative recruitment into studies remains challenging, variable rates between different hospitals are well-known challenges. This study aims to characterise patterns across England’s secondary tertiary care National Health Service (NHS) Trusts registered on the Institute Care Research (NIHR) Clinical Network (CRN) portfolio. Design/method Recruitment data...
Immune checkpoint inhibitor (ICI) medications are increasingly widely used for the treatment of certain forms cancer. Although they offer significant prognostic benefits, associated with a broad spectrum immune-related adverse effects (irAEs). Checkpoint colitis (CIC) is considered most severe and common cause discontinuation ICI. The risk CIC varies by mechanism action ICI in question whether combination immunotherapy used. diagnosed endoscopically, including histology. Differential...