A5084258077- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Eosinophilic Disorders and Syndromes
- Rheumatoid Arthritis Research and Therapies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
University of Oxford
2020-2023
Abstract IFNγ is an immune mediator with concomitant pro- and anti-tumor functions. Here, we provide evidence that directly acts on intra-tumoral CD8 T cells to restrict responses. We report expression of the receptor β chain (IFNγR2) in negatively correlates clinical responsiveness checkpoint blockade metastatic melanoma patients, suggesting loss sensitivity contributes successful antitumor immunity. Indeed, specific deletion IFNγR promotes tumor control a mouse model melanoma. Chronic...
Lymphocyte homeostasis and immune surveillance require that T B cells continuously recirculate between secondary lymphoid organs. Here, we used intravital microscopy to define lymphocyte trafficking routes within the spleen, an environment of open blood circulation shear forces unlike other Upon release from arterioles into red pulp sinuses, latched onto perivascular stromal in a manner was independent chemokine receptor CCR7 but sensitive Gi protein-coupled inhibitors. This latching...
The first immune-activating changes within joint resident cells that lead to pathogenic leukocyte recruitment during articular inflammation remain largely unknown. In this study, we employ state-of-the-art confocal microscopy and image analysis in a systemic, whole-organ, quantitative way present evidence synovial begins with the activation of lining macrophages. We show lining, but not sublining macrophages phagocytose immune complexes containing model antigen. Using antigen-induced...
The mechanisms that regulate germinal center (GC) B cell responses in the spleen are not fully understood. Here we use a combination of pharmacologic and genetic approaches to delete SIGN-R1
The PI3K pathway plays a key role in B cell activation and is important for the differentiation of Ab producing plasma cells (PCs). Although much known about molecular mechanisms that modulate signaling cells, transcriptional regulation expression poorly understood. In this study, we identify zinc finger protein Zbtb18 as repressor directly binds enhancer/promoter regions genes encoding class I regulatory subunits, subsequently limiting their expression, dampening suppressing PC responses....