A5004981696- CAR-T cell therapy research
- Microfluidic and Bio-sensing Technologies
- Viral Infectious Diseases and Gene Expression in Insects
- Transgenic Plants and Applications
- Nanowire Synthesis and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrohydrodynamics and Fluid Dynamics
Korea University
2021
Whole-cell-based therapy has been extensively used as an effective disease treatment approach, and it rapidly changed the therapeutic paradigm. To fully accommodate this shift, advances in genome modification cell reprogramming methodologies are critical. Traditionally, molecular tools such viral polymer nanocarriers electroporation have norm for internalizing external biomolecules into cells cellular engineering. However, these approaches not satisfactory considering their cytotoxicity,...
Effective tumor regression has been observed with chimeric antigen receptor (CAR) T cells; however, the development of an affordable, safe, and effective CAR-T cell treatment remains a challenge. One major obstacles is that suboptimal genetic modification cells reduces their yield antitumor activity, necessitating next-generation engineering approach. In this study, we developed nonviral nanoengineering system allows highly efficient delivery diverse functional nanomaterials into primary...