Abstract Background: Limited data are available on the contemporary incidence of gastroesophageal junction cancer (GEJC) and gastric (GC). This study aimed to examine rates trends GEJC GC overall by gender race/ethnicity. Methods: In this cross-sectional study, we used 2016-2021 from U.S. Epidemiology, End Results (SEER) 22 registries. Per primary International Classification Diseases for Oncology, 3rd Edition (ICD-O-3) SEER, cases were identified “C16.0 Cardia” under “C16 Stomach”....

The role of clay diagenesis in pressure-ramp (overpressure) development is evaluated from Mesozoic mudstone well cuttings the Egersund Basin, Norwegian Continental Shelf. Major changes mineral assemblage over range increasing geopressure include ~50% decrease detrital kaolinite bulk material, and increases proportions illite, I-S, percent nonexpandable illite-like layers I-S. SEM TEM observations confirm that pore space defined primarily by intersecting clay-mineral packets at scale tens or...

Background: Diagnostic pathways for patients presenting with cognitive complaints may vary across geographies. Objective: To describe diagnostic of 6 countries. Methods: This real-world, cross-sectional study analyzed chart-extracted data from healthcare providers (HCPs) 6,744 China, France, Germany, Spain, UK, and the US. Results: Most common symptoms at presentation were (memory/amnestic; 89.86%), followed by physical/behavioral (87.13%). Clinical/cognitive tests used in > 95%,...

Biomarker testing is increasingly crucial for patients with early-stage non-small cell lung cancer (eNSCLC). We explored biomarker test utilization and subsequent treatment in eNSCLC the real-world setting. Using COTA's oncology database, this retrospective observational study included adult ≥ 18 years old diagnosed (disease stage 0–IIIA) between January 1, 2011 December 31, 2021. Date of first diagnosis was index date. reported rates by year who received any within 6 months each molecular...

Abstract In this hypothesis-generating analysis, we examined whether longitudinal changes in patient-reported outcomes (PROs), such as symptoms, over time would be prognostic for progression-free survival (PFS) and overall (OS) patients with diffuse large B-cell lymphoma (DLBCL) who were newly treated obinutuzumab (G) combination CHOP (G-CHOP) or rituximab (R) (R-CHOP), the GOYA Phase 3 trial (NCT01287741). Our results show that from study baseline to cycle day 1, every 1-point increase...

The purpose of this retrospective, population-based, observational cohort analysis was to assess whether routine patient-reported outcomes (PRO) monitoring alone has an impact on real-world overall survival (OS) and hospitalizations among individuals diagnosed with lung, breast or colorectal cancer. importance follow-up care in post-PRO data collection also discussed.

Background: To estimate the cost of US hospital admissions and outpatient surgeries associated with achondroplasia. Materials & methods: Using 2017 data from nationally representative databases, this study identifies encounters an achondroplasia diagnosis. Descriptive measures are reported. Results: There were 1985 nationwide. The most frequent neonatal care (33.7%) in children musculoskeletal (22.7%) adults. Average length stay was 6.8 days, 2.2 days longer than mean. Total mean inpatient...

Abstract Background Use of neuroimaging [e.g. magnetic resonance imaging (MRI), positron emission tomography (PET), or computed (CT) scan], cerebrospinal fluid (CSF), and blood biomarker tests can contribute to a more accurate earlier diagnosis Alzheimer’s disease (AD). This study aimed examine real‐world utilization existing diagnostic for mild cognitive impairment (MCI), AD, other dementias in large US elderly population. Method Using data from the Medicare 100% Research Identifiable...

Abstract Background Recent advances in Alzheimer’s Disease (AD) disease modifying therapies (DMTs) emphasize the need of an early, timely and accurate diagnosis to initiate treatment improve patient outcomes. Clinicians must confirm amyloid pathology through cerebrospinal fluid (CSF) testing or positron emission tomography (PET) scan qualify patients. As a result, demand for confirmatory CSF imaging biomarker is predicted rise significantly. Method We developed model analyze diagnostic...

Aim: To compare rates of biologic initiation after commencing treatment with apremilast (APR) versus methotrexate (MTX) in systemic-naive patients psoriasis (PsO). Methods: This was a retrospective cohort study PsO who initiated APR or MTX between 1 January 2015 and 31 March 2018. Outcomes: Adjusted during follow-up were compared by logistic Cox regressions. Results: initiators had 58% lower likelihood (odds ratio: 0.42; 95% CI: 0.37-0.48; p < 0.001), adjusted rate (14.4% [95% 13.2-15.7%] vs...

337 Background: This study aimed to assess treatment adherence, healthcare resource utilization and costs in patients with GI NETs who initiated pharmacologic treatments. Methods: In 2 US commercial claims databases, ≥18 years ≥1 inpatient or ≥2 outpatient for were identified. The first claim treatments (e.g. somatostatin analogues [SSAs], cytotoxic chemotherapy [CC], targeted therapy) following diagnosis between 7/1/2009 12/31/2013 was defined as the index date. A 6-month clean period...

Abstract Background Diagnostic pathways from cognitive impairment (CI) to Alzheimer’s disease (AD) are complex and vary geographically. This study aimed quantify compare the current diagnostic in six countries. Methods A real‐world, cross‐sectional survey of 1,694 health care professionals (HCPs) was conducted countries (US, China, UK, France, Germany Spain) October November 2021. HCPs provided data for 6,744 patients including patient demographics, presenting symptoms, tests procedures....

Abstract Background This study aims to detect direct cost savings with early detection of Alzheimer’s disease (AD) and related dementias. We hypothesize that earlier diagnosis AD can reduce healthcare costs unnecessary utilization. A retrospective case‐control is conducted using Optum Market Clarity Claims/EHR linked dataset on Medicare Advantage population from Jan 1 2011 Dec 31 2020. Method Based whether the patient was diagnosed prior Mild Cognitive Impairment (MCI) before progressing an...

Trauma patients at high risk of thrombosis and bleeding often have a retrievable inferior vena cava filter (IVCF) inserted prophylactically shortly after admission for the prevention pulmonary embolism. Despite their increasing use in trauma, controversy exists regarding patient selection, benefits safety. In addition, chemical prophylaxis should be initiated as soon determined to safe do so. Limited data exist describing timing it relation IVCF placement this population. We aim describe...

Abstract Purpose This study assessed the impact of adherence to guidelines-recommended diagnostic testing on treatment selection and overall survival (OS) in patients with diffuse large B-cell lymphoma (DLBCL) initiated rituximab-based first line (1-LOT). Methods retrospective cohort used a nationwide electronic health record-derived de-identified database, including information immunohistochemistry (IHC), fluorescence situ hybridization (FISH) karyotype analysis that were abstracted from...