A5073546451- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- Colorectal Cancer Screening and Detection
- Economic and Financial Impacts of Cancer
- Nutritional Studies and Diet
- Trauma and Emergency Care Studies
- Hippo pathway signaling and YAP/TAZ
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Healthcare cost, quality, practices
- Cholesterol and Lipid Metabolism
- Neuroendocrine Tumor Research Advances
- Ethics in Clinical Research
- Mental Health and Patient Involvement
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Nutrition and Health in Aging
- Cancer Risks and Factors
- Patient-Provider Communication in Healthcare
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Consumer Attitudes and Food Labeling
- RNA Interference and Gene Delivery
University of Calgary
2023-2024
McGill University
2021-2023
University of Ottawa
2019-2021
The prevention and treatment of cardiovascular diseases (CVD) has largely focused on lowering circulating LDL cholesterol, yet a significant burden atherosclerotic disease remains even when is low. Recently, microRNAs (miRNAs) have emerged as exciting therapeutic targets for disease. miRNAs are small noncoding RNAs that post-transcriptionally regulate gene expression by degradation or translational inhibition target mRNAs. A number been found to modulate all stages atherosclerosis,...
Background: The coronavirus disease 2019 (COVID-19) pandemic has caused disruptions to cancer care by delaying diagnoses and treatment, presenting challenges uncertainties for both patients physicians. We conducted a nationwide online survey investigate the effects of capture modifications, prompted pandemic-related control measures, on cervical screening-related activities from mid-March mid-August 2020, across Canada. Methods: consisted 61 questions related continuum in screening...
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer, accounting for majority cancer-related death. Due to lack specific therapeutic targets, chemotherapeutic agents (e.g., paclitaxel) remain mainstay systemic treatment, but enrich a subpopulation cells with tumor-initiating capacity and stem-like characteristics called stem (CSCs); thus development new effective strategy TNBC treatment an unmet medical need. Cancer nanomedicine has transformed landscape...
The association between red meat consumption and colorectal cancer has been rigorously examined. However, a more comprehensive understanding of how the intake unprocessed contributes to development early precancerous lesions, such as advanced adenomas (ACRAs), requires further investigation. We examined associations different types ACRAs in sample population 1083 individuals aged ≥ 50 years undergoing an initial screening colonoscopy Calgary, Alberta, Canada. Associations grams per day...
Improved understanding of the biological heterogeneity breast cancer (BC) has facilitated development more effective and personalized approaches to treatment. This study describes real-world evidence on treatment patterns outcomes for a population-based cohort patients with human epidermal growth factor receptor (HER2) IHC0 -low BC de novo or recurrent disease from Alberta, Canada. Patients 18+ years old diagnosed HER2 IHC0/-low, novo/recurrent 2010 2019 were identified using Alberta's...
Abstract Objectives Disparities in colorectal cancer (CRC) screening uptake by socioeconomic status have been observed Canada. We used the OncoSim-Colorectal model to evaluate health and economic outcomes associated with increasing participation rates of CRC programs 60% among Canadians different income quintiles. Methods Baseline were obtained from 2017 Canadian Community Health Survey. The survey participants categorized into quintiles using their reported household 2016 Census quintile...
Activation of the transcription factor liver X receptor (LXR) has beneficial effects on macrophage lipid metabolism and inflammation, making it a potential candidate for therapeutic targeting in cardiometabolic disease. While small molecule delivery via nanomedicine promising applications number chronic diseases, questions remain as to how nanoparticle formulation might be tailored suit different tissue microenvironments aid drug delivery. In current study, we aimed compare vitro delivering...
The impact of cancer in Alberta is expected to grow considerably, largely driven by population growth and aging. Future Cancer Impact (FOCI) initiative offers an overview the present state care highlights potential opportunities for research innovation across continuum. In this paper, we a series detailed projections analyses regarding epidemiological estimates Alberta, Canada. Data on incidence mortality (1998–2018) limited-duration prevalence (2000–2019) were collected from Registry. We...
(1) Background: The COVID-19 pandemic illuminated vulnerabilities in the Canadian health care system and exposed gaps challenges across cancer continuum. Canada is experiencing significant disruptions to cancer-related services, impact these (delays/deferrals/cancellations) have on patients are yet be determined. Given potential adverse ramifications, how can Canada's systems build resilience for future threats? (2) Methods: To answer this question, CCC facilitated a series of four...
The purpose of this retrospective, population-based, observational cohort analysis was to assess whether routine patient-reported outcomes (PRO) monitoring alone has an impact on real-world overall survival (OS) and hospitalizations among individuals diagnosed with lung, breast or colorectal cancer. importance follow-up care in post-PRO data collection also discussed.
Abstract Triple negative breast cancer (TNBC) accounts for the majority of cancer‐related deaths and remains hardest to treat due lack specific therapeutic targets. While chemotherapy is mainstay systemic treatment TNBC, it associated with chemotherapy‐induced stem cells (CSCs) tumor regeneration. Here, found that Wnt YAP target genes have been closely CSCs are highly expressed in TNBC patient tumors negatively correlated survival. Therefore, a nanotherapeutic strategy employed, using...
This commentary provides a detailed overview of the extensive stakeholder engagement efforts critical to development Future Cancer Impact (FOCI) in Alberta report. The overarching aim FOCI report was support informed and strategic discussions actions that will help key stakeholders province prepare for future with increasing cancer incidence survival. Employing comprehensive approach diverse range activities, insights from wide spectrum were gathered subsequently used shape content inclusive...
<title>Abstract</title> Purpose There is limited evidence regarding body mass index (BMI) as an early marker of high-risk adenoma (HRA) at the time screening colonoscopy. Because adenomas can develop into colorectal cancer (CRC), BMI could serve important clinical predictor future risk CRC. Methods We examined data from 1,831 adults undergoing colonoscopy Forzani & MacPhail Colon Cancer Screening Centre in Alberta, Canada. fit multivariable logistic regression models to examine...
Abstract Activation of the transcription factor liver X receptor (LXR), has shown to be efficient at curbing aberrant lipid metabolism and inflammation. While small molecule delivery via nanomedicine promising applications for a number chronic diseases, there remain questions as how nanoparticle formulation might tailored suit different tissue microenvironments aid in drug delivery. In current study, we compared capability three (NP) formulations encapsulating LXR activator, GW-3956. We...
Background: Body mass index (BMI) is an important risk factor for the development of high-risk colorectal adenomas (HRA), however, there limited evidence regarding BMI as early marker cancer (CRC) in a screening population. Methods: We examined 1,850 adults undergoing CRC at Forzani & MacPhail Colon Cancer Screening Centre Alberta, Canada. fit logistic regression models to examine association between and HRA. Multivariable were adjusted pre-selected set potential confounders. Non-linear...
Abstract Background The COVID-19 pandemic has caused disruptions to cancer care by delaying diagnoses and treatment, presenting challenges uncertainties for both patients physicians. We conducted a nationwide online survey investigate the effects of capture modifications, prompted pandemic-related control measures, on cervical screening-related activities from mid-March mid-August 2020, across Canada. Methods consisted 61 questions related continuum in screening treatment: appointment...