A5064368735- Nerve injury and regeneration
- Amyotrophic Lateral Sclerosis Research
- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- RNA Interference and Gene Delivery
- Genetic Neurodegenerative Diseases
- Infectious Encephalopathies and Encephalitis
- Virus-based gene therapy research
- Reproductive System and Pregnancy
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- Vagus Nerve Stimulation Research
- Cerebral Palsy and Movement Disorders
- Pregnancy and Medication Impact
- Retinoids in leukemia and cellular processes
- Neurological disorders and treatments
- Cholinesterase and Neurodegenerative Diseases
- Heart Rate Variability and Autonomic Control
University of Thessaly
2025
University of West Attica
2022-2025
University College London
2025
National and Kapodistrian University of Athens
2023-2025
University of Crete
2022-2024
Foundation for Research and Technology Hellas
2022-2024
FORTH Institute of Molecular Biology and Biotechnology
2022-2024
University General Hospital Attikon
2022
Abstract Background Neural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless, neurogenic niches persist adult cortex hippocampus rodents, primates humans, with NSC sharing key regulatory mechanisms development. Adult neurogenesis impairments have been linked Alzheimer’s disease (AD) pathology. Addressing these by using neurotrophic factors is a promising new avenue for therapeutic intervention based on neurogenesis....
Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA low-affinity, pro-apoptotic p75NTR receptors. NGF has been shown to slow or prevent neurodegenerative signals in Alzheimer’s Disease (AD) progression. However, low bioavailability blood–brain-barrier impermeability limit use as a potential therapeutic agent against AD. Based...
Neuronal cell fate is predominantly controlled by the effects of growth factors, such as neurotrophins, and activation a variety signaling pathways acting through neurotrophin receptors, namely Trk p75 (p75NTR). Despite their beneficial on brain function, therapeutic use compromised, due to polypeptidic nature blood–brain-barrier impermeability. To overcome these limitations, our previous studies have proven that DHEA-derived synthetic analogs can act like lacking endocrine side...
Neuronal cell fate is predominantly controlled based on the effects of growth factors, such as neurotrophins, and activation a variety signaling pathways acting through neurotrophin receptors, namely Trk p75 (p75NTR). Despite their beneficial brain function, therapeutic use compromised due to polypeptidic nature blood-brain-barrier impermeability. To overcome these limitations, our previous studies have proven that DHEA-derived synthetic analogs can act like they lack endocrine side effects....