A5017171698- Rheumatoid Arthritis Research and Therapies
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Immunology Research
- Neuroscience and Neuropharmacology Research
- Cell Adhesion Molecules Research
- Martial Arts: Techniques, Psychology, and Education
- Toxin Mechanisms and Immunotoxins
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Cannabis and Cannabinoid Research
- Chronic Lymphocytic Leukemia Research
- Education and Learning Interventions
- RNA and protein synthesis mechanisms
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Genetics and Physical Performance
- interferon and immune responses
- T-cell and B-cell Immunology
- PI3K/AKT/mTOR signaling in cancer
- Prion Diseases and Protein Misfolding
- Physical Education and Training Studies
Hanmi Pharmaceutical (South Korea)
2022
Hyogo Medical University
2022
Kyoto Pharmaceutical University
2018
Santen (Japan)
2007-2012
Tokyo Medical and Dental University
2010
Hokkaido University
2002
Recent studies demonstrate that extracellular-released aminoacyl-tRNA synthetases (aaRSs) play unique roles in immune responses and diseases. This study aimed to understand the role of extracellular aaRSs pathogenesis rheumatoid arthritis (RA).Primary macrophages fibroblast-like synoviocytes were cultured with aaRSs. aaRS-induced cytokine production including IL-6 TNF-α was detected by ELISA. Transcriptomic features aaRS-stimulated examined using RNA-sequencing. Serum synovial fluid (SF)...
This study was performed to elucidate the molecular function of synoviocyte proliferation-associated in collagen-induced arthritis (CIA) 1/serum amyloid A-like 1 (SPACIA1/SAAL1) mice CIA, an animal model rheumatoid (RA), and human RA-synovial fibroblasts (RASFs). SPACIA1/SAAL1-deficient were generated used create mouse models CIA mild or severe disease conditions. Cell cycle-related genes, whose expression levels affected by SPACIA1/SAAL1 small interfering RNA (siRNA), screened....
In the present study, we investigated effects and mechanisms of action a combined treatment with etanercept, soluble tumor necrosis factor receptor (p75) Fc fusion protein, tacrolimus, calcineurin inhibitor on progression arthritis in human factor- α (TNF- ) transgenic (hTNF-Tg) mice. Single-drug treatments etanercept tacrolimus attenuated clinical signs but not radiographic changes associated development On contrary, significantly suppressed also improved signs. The exhibited synergistic...
ABSTRACT A simple conventional method of immunohistochemistry (i.e. fixing the frozen sections in cold methanol) was used to determine immunolocalization cellular prion protein (PrPc), with good results. In rat cerebrum, cytoplasm neural cells cortex and corpus stratum, pia mater, membrane limitans gliae superficialis, choroid plexus blood vessel wall were immunostained. The formation network structures immunostained and/or glial fibers cerebral also observed. These observed cultured cells....
Acetaminophen is widely used for the treatment of fever and pain. Although analgesic effect acetaminophen had been previously thought to be due its anti–inflammatory action by inhibiting prostaglandin production based on cyclooxygenase inhibition, it currently considered that exerts effects through central actions AM404, a metabolite acetaminophen. However, mechanism not yet fully understood. In present study, we focused locus coeruleus (LC), which contains largest population noradrenergic...